Reference: Flynn MM, Tierney A, Itsiopoulos C. Is extra virgin olive oil the critical ingredient driving the health benefits of a Mediterranean diet? Nutrients. 2023;15:2915.
A recent scientific review, published in the journal Nutrients, provides strong evidence that the phenols in EVOO—which are not present in lower grades of olive oil—play a primary role in the heart-health benefits associated with olive oil and the Mediterranean diet.
Phenols are bioactive compounds in plant-based foods. EVOO is rich in phenols, whereas refined olive oils are stripped of these health-promoting compounds by chemical production processes.
Study Objectives
Dr. Mary Flynn, PhD, registered dietician, and associate professor of medicine at Brown University, identified 34 randomized, controlled trials published between 2000 and 2022 that evaluated the effects of EVOO on risk factors for heart disease: blood pressure, levels of LDL (“bad”) and HDL (“good”) cholesterol, blood sugar, and body weight.
A main aim of the review was to isolate the effects of the phenols in EVOO from the potential effects of monounsaturated fatty acids (MUFAs), which are present in all grades of olive oil and other vegetable oils. Flynn hypothesized that the MUFA content is not responsible for the many health benefits of EVOO.
Another objective was to identify a minimum daily amount of EVOO required to experience its health benefits and the timing for improvements in heart-health risk factors to be observed.
Findings
Across the 34 studies, EVOO improved multiple risk factors for heart disease as compared to other grades of olive oil, other plant oils, and low-fat diets:
Lowered blood pressure
Lowered LDL and increased HDL
Improved insulin sensitivity
Proved effective in weight-loss diets and improved long-term weight management
Daily dose of EVOO
According to Flynn and colleagues, “Daily use of EVOO starting at approximately two tablespoons a day will improve a plethora of risk factors in as few as three weeks.”
Phenomenal phenols
It is the phenols in EVOO that confer its heart-health benefits, the authors concluded. In order to obtain optimal levels of phenols, they recommend consuming the freshest olive oil: “The phenol content of extra virgin olive oil is highest in olive oil made close to the harvesting of the olive and will decrease with age and storage. Thus, for maximum health benefits, the EVOO should be produced and consumed as close to harvesting the fruit as possible.”
The authors noted some limitations of this review: most studies did not include the specific phenolic content of the EVOO used, and many were conducted in the EU, where EVOO has been a part of the diet for centuries. More investigation, especially studies that identify the specific levels of phenols, is needed to confirm and build on these findings.
Garlic-and-Pepper-Crusted Beef Tenderloin Recipe, Spotlight on Garlic, Testing Meat for Doneness, Mindfulness Can Help You Stick with a Special Diet and Even Sleeping is Better for You than Sitting
Looking for a festive holiday entrée? My Garlic-and-Pepper-Crusted Beef Tenderloin fits the bill for any celebration. Its two-step cooking method is virtually foolproof—it keeps the tender in tenderloin! I hope you’ll enjoy this sneak peek at my latest e-book, Savor the Season: Winter 2024, a collection of recipes featuring healthy and hearty seasonal dishes. Also in this edition of The Olive Oil Hunter Newsletter is information on how to use mindfulness to stick to a specialized diet and why even sleep is better for you than sitting.
There’s nothing more celebratory than a beef tenderloin, and because it takes on the intense flavors in the crust, there’s no need for further embellishment. The center cut is the most choice, tender, and lean part of the tenderloin.
Ingredients
8 cloves garlic, peeled
2 tablespoons coarse salt
1/3 cup extra virgin olive oil, plus 2 tablespoons for searing
1 tablespoon freshly and coarsely cracked black peppercorns
2 tablespoons fresh thyme leaves
1/4 cup fresh rosemary needles from a 3- or 4-inch sprig
2 tablespoons grainy mustard
One 3-pound center-cut beef tenderloin, trimmed as needed
Directions
Step 1
Preheat your oven to 450ºF. In a small food processor, process the garlic and salt until the garlic is finely chopped. Add the 1/3 cup olive oil, black pepper, thyme, and rosemary, and process until the herbs are evenly chopped. Stir in the mustard and set aside.
Step 2
Heat a large cast-iron skillet or Dutch oven on the stovetop over medium-high heat. When hot, add the 2 tablespoons of olive oil and then the beef, searing it on all sides until nicely browned, 3 to 4 minutes per side, making quarter turns with tongs. Transfer the meat to a cutting board and let cool slightly.
Step 3
Coat the meat evenly on all sides with the reserved herb mixture. Transfer the tenderloin to a meat rack set in a roasting pan. Roast the tenderloin until the internal temperature reaches your desired doneness on an instant-read thermometer, about 20 to 30 minutes (depending on its thickness). Let it rest for at least 10 minutes before carving to prevent the juices from running out.
Yields 8 servings
Healthy Ingredient Spotlight
Garlic
Beyond adding wonderful flavor, garlic contains a powerful compound called allicin, released soon after the cloves are crushed or chopped—after you do your prep, wait 10 minutes before using the garlic to allow the allicin to develop. When I buy garlic, I always buy organic, and I always turn over the head to make sure there’s still some of the root network, a sign that it’s American grown. Beware of Chinese imports, bleached in chlorine to artificially enhance their appearance with a concave area on the bottom where the roots used to be.
Quick Kitchen Nugget
Testing Meat for Doneness
No matter what your preference for doneness, test with an instant-read thermometer inserted in the thickest part of the meat. Rare is 120º to 130ºF; medium rare, 130º to 135ºF; medium, 135º to 145ºF; medium well, 145º to 155ºF; and well, 165ºF. Keep in mind that when you take a roast out of the oven, it will continue to cook and can go up by another 5 degrees, so plan accordingly.
For Your Best Health
Mindfulness can Help You Stick with a Special Diet
A Brown Universitystudy, published in JAMA Network Open, found that participants in an eight-week mindfulness-based blood pressure reduction program improved health behaviors that lower blood pressure. “Participants in the program showed significant improvement in adherence to a heart-healthy diet, which is one of the biggest drivers of blood pressure, as well as significant improvements in self-awareness, which appears to influence healthy eating habits,” said lead study author Eric B. Loucks, PhD, an associate professor of medicine, epidemiology, and behavioral and social sciences, as well as director of the Mindfulness Center at Brown University.
Dr. Loucks said the study helps explain the mechanism by which a customized mindfulness training program adapted toward improving diet can affect blood pressure. “Improvements in our self-awareness, of how different foods make us feel, of how our body feels in general, as well as our thoughts, emotions, and physical sensations around eating healthy as well as unhealthy food, can influence people’s dietary choices,” he said.
High blood pressure, a major cause of cardiovascular disease, is the single most important risk factor for early death worldwide, according to a recent report by the World Health Organization, leading to an estimated 10.8 million avoidable deaths every year. The important thing to note about those avoidable deaths, Dr. Loucks said, is that there is ample research supporting effective strategies to control and prevent hypertension. “Almost everyone has the power to control blood pressure through changes in diet and physical activity, adherence to antihypertensive medications, minimizing alcohol intake, and monitoring stress reactivity,” he said.
The mindfulness-based blood pressure reduction program used in the study, which Dr. Loucks developed in 2014, trains participants in skills such as meditation, yoga, self-awareness, attention control, and emotion regulation. What makes the program unique, he said, is that participants learn how to direct those skills toward behaviors known to lower blood pressure. The researchers focused on participant adherence to the DASH (dietary approaches to stop hypertension) program, a balanced eating plan rich in fruits, vegetables, whole grains, and low-fat dairy intended to create a heart-healthy eating style for life. Despite its effectiveness, adherence to the DASH diet is typically low.
After six months, the mindfulness group showed a 0.34-point improvement in the DASH diet score. Loucks explained that this effect can be interpreted as a participant shifting from a vegetable intake approaching recommended levels (2-3 servings) to an intake at recommended levels (at least 4 servings), or making similar shifts across another component of the DASH score. The control group showed a -0.04-point change in the DASH diet score.
The trial results offer evidence that an adapted mindfulness training program for participants with high blood pressure that targets diet and self-awareness significantly improves both. “The program gives participants the tools to make heart-healthy diet changes that can lower their blood pressure and decrease their risk of cardiovascular disease,” Dr. Loucks said.
Fitness Flash
Even sleeping is better for you than sitting!
A new study, published in the European Heart Journal, is the first to assess how different movement patterns throughout the 24-hour day are linked to heart health. It is the first evidence to emerge from the international Prospective Physical Activity, Sitting and Sleep (ProPASS) consortium.
Researchers at University College London (UCL) in the UK analyzed data from six studies involving 15,246 people from five countries, each of whom used a wearable device on their thigh to measure their activity and had their heart health measured. The scientists identified a hierarchy of behaviors that make up a typical 24-hour day, with time spent doing moderate-vigorous activity providing the most benefit to heart health, followed by light activity, standing, and sleeping, compared with the adverse impact of being sedentary.
The team modeled what would happen if someone changed various amounts of one behavior for another each day for a week in order to estimate the effect on heart health for each scenario. When replacing sedentary behavior, as little as five minutes of moderate-vigorous activity had a noticeable effect on heart health.
First author of the study Joanna Blodgett, PhD, of the Institute of Sport Exercise and Health, Division of Surgery and Interventional Sciences at UCL, said, “The big takeaway from our research is that while small changes to how you move can have a positive effect on heart health, intensity of movement matters. The most beneficial change we observed was replacing sitting with moderate-to-vigorous activity, which could be a run, a brisk walk, or stair climbing—basically any activity that raises your heart rate and makes you breathe faster, even for a minute or two.”
The research found that, although time spent doing vigorous activity was the quickest way to improve heart health, there are ways to benefit no matter what your abilities—it’s just that the lower the intensity of the activity, the longer the time needed to start having a tangible benefit. Using a standing desk for a few hours a day instead of a sitting desk, for example, is a change over a relatively large amount of time but is also one that could be integrated into a working routine fairly easily, as it does not require any time commitment. Those who were least active were also found to benefit the most from changing from sedentary behaviors to more active ones.
James Leiper, MD, PhD, associate medical director at the British Heart Foundation, the organization supporting the research, said, “We already know that exercise can have real benefits for your cardiovascular health, and this encouraging research shows that small adjustments to your daily routine could lower your chances of having a heart attack or stroke. This study shows that replacing even a few minutes of sitting with a few minutes of moderate activity can improve your BMI, cholesterol, and waist size, and have many more physical benefits.
“Getting active isn’t always easy, and it’s important to make changes that you can stick to in the long term and that you enjoy—anything that gets your heart rate up can help. Incorporating ‘activity snacks’ such as walking while taking phone calls or setting an alarm to get up and do some star jumps every hour is a great way to start building activity into your day, to get you in the habit of living a healthy, active lifestyle,” Dr. Leiper continued.
Though the findings cannot infer causality between movement behaviors and cardiovascular outcomes, they contribute to a growing body of evidence linking moderate to vigorous physical activity over 24 hours with improved body fat metrics. Further long-term studies will be crucial to better understanding the associations between movement and cardiovascular outcomes.
Chicken Saag with Homemade Garam Masala Recipes, Spotlight on Cinnamon and Black Peppercorns, Spices and Your Health, and Food as Medicine
Over the course of 20-plus years traveling the globe—first as a food, wine, and travel writer and then as The Olive Oil Hunter—I’ve savored dozens of delicious and diverse cuisines at farmers’ tables, Michelin-starred restaurants, and everything in between. As different as these meals were, they shared one common denominator: the masterful use of spices—spices that weren’t common at all but rather were the brightest and most intense.
Over the next four newsletters, I’m going to share the eight essentials I reach for most often, with recipes and tips for using them, starting with cinnamon and black pepper. I love them all so much, I’ve put them together in a collection for you, the latest of my Curated Culinary Selections.
Also in this issue is news about a very important initiative from the American Heart Association called Food Is Medicine. It focuses on diet as prevention, something those who follow the Mediterranean diet for the health benefits of olive oil, nuts, fruits, and vegetables know so well.
Many home chefs shy away from exotic cuisines, but you can master any dish with the right ingredients, starting with the right spices. There are as many recipes for the essential Indian spice blend garam masala as there are chefs! This truly exceptional one comes from my friend Prasad Chirnomula, a trailblazing chef and restaurateur in Connecticut whose latest restaurant is Chef Prasad in New Canaan. Prasad’s amazing chicken saag, which uses garam masala, follows.
Ingredients
2 teaspoons cumin seeds
1 teaspoon freshly ground black peppercorns
2 teaspoons coriander seeds
3 bay leaves
2 teaspoons cloves
1 teaspoon green cardamom
2 pods wild cardamom if available
3 pieces star anise
1/2 teaspoon cinnamon
Directions
Heat a heavy-bottomed pan on medium heat and sauté all the spices, except the cinnamon, until fragrant, about 3 minutes—don’t step away, as they can easily burn. Cool slightly and process in a spice or coffee bean grinder (you may need to do this in two batches). Transfer to a bowl, whisk in the cinnamon, and then funnel into an airtight glass storage jar.
This Indian classic is brimming with vegetables and wonderful spices.
Ingredients
6 cups fresh spinach, tightly packed, washed, and drained, or 2 cups frozen spinach, defrosted
1 tablespoon butter
2 tablespoons extra virgin olive oil
1 teaspoon cumin seeds
1 large white onion, chopped
2 green chilis, stemmed and finely sliced
1 tablespoon ginger garlic paste*
1/2 teaspoon Garam Masala
1/2 teaspoon cayenne powder
1/2 salt or to taste
1 cup fresh chopped tomatoes or diced canned tomatoes
2 pounds boneless, skinless chicken breast or thighs, cut into 3/4-inch cubes
1/2 teaspoon freshly grated nutmeg
1/2 teaspoon dry fenugreek leaf (crushed to powder)
1/4 cup heavy cream, optional
Directions
Step 1
If using fresh spinach, blanch it for 1 minute in a large pot of boiling water, and then use a large strainer to transfer it to a large bowl of ice water to stop the cooking and set the color. Squeeze out the excess water, place the spinach in a blender, and purée it; set aside. If using frozen spinach, once it has thawed, squeeze it gently to remove any excess liquid.
Step 2
Heat a large skillet and, when it’s hot, add the butter and olive oil. Add cumin seeds, onion, and chilis and cook for 5 minutes or until the onions are light brown. Add ginger garlic paste, garam masala, cayenne, salt, and tomatoes and cook for another 5 minutes. Add the chicken and cook until firm and cooked through, 5 to 8 minutes, flipping the pieces halfway through. Add the nutmeg and fenugreek and stir for 2 minutes, then add the puréed spinach and a cup of water, and cook for another 5 minutes. For a creamier sauce, add the heavy cream and cook 3 to 5 more minutes. Serve with naan or over basmati rice.
*To make your own ginger garlic paste, in a small food grinder process 2 ounces peeled garlic cloves, 1 ounce peeled fresh ginger, and 1 teaspoon olive oil to a paste consistency, adding water by the teaspoon if necessary.
Yields 4 to 6 servings
Healthy Ingredient Spotlight
Cinnamon and Black Peppercorns
Heirloom Vietnamese Cinnamon
Cinnamon has been valued the world over for centuries for medicinal purposes, for religious ceremonies, to make fragrances, and as a sweet and spicy recipe ingredient. Cinnamon became such a coveted commodity that wars raged between countries over its trade. The only “fight” today is over which cinnamon to use. There are a few different types, all species in the Lauraceae family: Ceylon cinnamon from Sri Lanka (known by the country’s former name), Indonesian cinnamon, cassia cinnamon from China, and, what I prefer for its intensity and spicy sweetness, Vietnamese cinnamon (Cinnamomum loureiroi).
Why you should have this spice in your kitchen: Reach for cinnamon to top your lattes and add sweet spice to smoothies and oatmeal. It elevates fruit-based desserts like apple crisp, a rich babka or richer baklava, brioche raisin bread or gingerbread, or spice cookies. It adds depth to both savory and sweet dishes, from dried-fruit-and-nut-laden Persian rice and Moroccan tagines to Mexican moles and churros to Vietnamese pho to Greek moussaka. Cinnamon is also a magical ingredient in many global spice blends that you can mix up and have ready to go for a dry rub or a flavor boost for hot drinks.
Vine-Ripened Black Peppercorns
Black pepper is the most widely used spice on the planet. The origin of black peppercorns (Piper nigrum, a member of the Piperaceae family) can be traced to Kerala, a province in southwest India, and their written history goes back at least 4,000 years. Once the most coveted spice in the world, peppercorns were the original “black gold.” Black pepper has a place in almost every cuisine, as you can tell from the fact that it’s part of spice mixes from Cajun blends to the French quatre épices to Indian garam masala.
I adore the vine-ripened black peppercornsgrown in one of the most exotic destinations on earth, the Zanzibar archipelago, nicknamed the “Spice Islands” for good reason. Its location just off the coast of east Africa, with fertile soil perfect for growing spices and other crops, put it at the heart of the spice trade for centuries.
Why you should have this spice in your kitchen: Enjoy freshly ground black pepper on favorite foods like eggs, mashed potatoes, and tuna salad. And have fun finding new ways to appreciate its flavor: It makes a perfect crust for steak or duck breast and enlivens roasted sweet potatoes and winter squashes, vegetable slaws, cold pasta salads, and the Italian pasta classic cacio e pepe.
Quick Kitchen Nugget
Tasting Spices
So often we add spices to recipes without taking the time to appreciate how they taste on their own. Get to know the flavor profile of a spice before you use it in a dish. Open the lid and inhale the aroma. How do you describe it? Sweet? Pungent? Herbal? (If you don’t smell anything, it’s past its prime and should be replaced.) Next, rub a pinch in the palm of one hand and inhale again. Does it have the same qualities as before, or new ones? Now place another pinch on your tongue and see how your taste buds react. Another way to experience a spice is to make a tea—stir a quarter-teaspoon into a small cup of boiling water and let it steep for five minutes. Take a sip. Swirl it around in your mouth as you would a good wine to engage all your taste buds.
For Your Best Health
Spices and Your Health
Even though we only enjoy pinches of spices at a time, they contain plant-based nutrients and have been used for health purposes for centuries. In ancient times, cinnamon was the go-to remedy for respiratory and digestive ills. We’re still learning about its benefits today. According to a review paper in Pharmacognosy Research, the phytochemicals in cinnamon could be good for brain health, boosting the brain’s ability to use glucose, the energy source that supplies every part of the body. They’re also being studied as a way to help lower blood pressure, manage diabetes, and boost heart health, along with fighting off cell damage caused by toxins in our environment.
Ancient Indian and Egyptian cultures used peppercorns as an anti-inflammatory agent, an analgesic, and even a preservative. Contemporary research has found that there’s science to back up those early practices, thanks to the enzymes in the compound piperine—they help the body better absorb both conventional and herbal medications. There’s even the possibility that it could play a role in the development of medications to combat conditions as varied as Parkinson’s, cancer, and depression. Although research is in the early stages, with most studies being done only in labs, one day there could be value well beyond great taste for making pepper an important part of the diet.
Fitness Flash
Why (the Right) Food is Medicine
According to the American Heart Association (AHA), an estimated 90% of the $4.3 trillion annual cost of healthcare in the US is spent on chronic diseases. An unhealthy diet is a major risk factor for many of them. That’s where the AHA’s Food Is Medicine (FIM) initiative comes in. It represents a paradigm shift focused on the role of healthy foods to treat, manage, and prevent specific chronic conditions in coordination with the healthcare sector. Interventions could one day include medically tailored meals and groceries and even “produce prescriptions.”
“To unlock the potential of Food Is Medicine and make it a regular and reimbursable component of healthcare, we need an ambitious and coordinated research approach,” said Kevin G. Volpp, MD, PhD, American Heart Association volunteer, chair of the Presidential Advisory writing group, director of the Center for Health Incentives and Behavioral Economics at the University of Pennsylvania, and research lead of the Food Is Medicine initiative. “By addressing research gaps and integrating research efforts in collaboration with stakeholders nationwide, we will fuel cross-sector efforts that ensure Food Is Medicine programs improve health costs effectively and are feasible in practice.”
FIM programs aren’t new, but the study of these interventions in healthcare has been limited by factors including small sample sizes, non-randomized comparisons, and broad differences in data collection and measurement, states the AHA. The advisory proposes a coordinated research approach to compare how well nutrition-based interventions treat and prevent disease compared to standard medical care. This approach is the foundation of the Food Is Medicine initiative, first announced by the American Heart Association and The Rockefeller Foundation at the White House Conference on Hunger, Nutrition and Health in September 2022.
“Food Is Medicine holds the promise to improve health outcomes for millions of patients living with or at risk for cardiovascular disease and other serious chronic health conditions,” said Mitchell S.V. Elkind, MD, chief clinical science officer of the American Heart Association, past volunteer president of the AHA, a member of the Presidential Advisory writing committee, and a tenured professor of neurology and epidemiology at Columbia University.
Quick Pickled Cucumbers Recipe, Spotlight on Red Wine Vinegar, Rimmed Sheet Pans, and Is Heart Disease in Your Genes?
Oil and vinegar—it’s a match made in culinary heaven. But just as the uses of EVOO go well beyond salads, so do those of vinegar. As an acid, vinegar adds brightness and zest to recipes. In a marinade, vinegar helps break down and tenderize protein fibers for juicier meat. It’s an amazing addition to classic sauces like beurre blanc and béarnaise. And it’s perfect for pickling—one of its earliest uses—because vinegar preserves foods as it imparts tartness. See how easy it is with my recipe for quick-pickled cucumbers using red wine vinegar.
Also in this issue…how to choose rimmed sheet pans (one of the most versatile pieces of bakeware)…and why some people are more prone to plaque buildup in arteries.
These cukes make a zesty side dish and a terrific addition to sandwiches, burgers, and salads. They’re ready in less than an hour, but the flavor will intensify the longer they marinate in the fridge (bring them back to room temperature before serving).
Ingredients
2 large cucumbers, trimmed, peel left on
1 large red onion
1 tablespoon sea salt
1 bell pepper, any color, cored and cut into thin rings
1/4 cup extra virgin olive oil
3 tablespoons red wine vinegar, plus more to taste
2 tablespoons dill, minced
Directions
Use a mandoline or the thin slicing blade of your food processor to slice the cucumbers and red onions. Transfer them to a colander nestled in a large bowl and toss with the salt. Let sit for an hour to release some of their liquid. Rinse with cold water to remove extra salt and rinse out the bowl. Place the cucumbers and onions in the bowl along with the pepper rings. Add the olive oil, vinegar, and dill, and toss well. Allow the flavors to meld for at least 30 minutes before serving.
Yields 6 servings
Healthy Ingredient Spotlight
Red Wine Vinegar
Red wine vinegar is a must for your pantry. You’ll reach for it for quick-pickling, for making vegetable salads, and as a finishing touch for caramelized vegetables from beets to potatoes and for fatty fish like salmon, tuna, and cod, as well as fried fish.
But red wine vinegar is only as good as the grapes used to make it, and that’s why mine comes from the Roboredo Madeira family. Members of the Fresh-Pressed Olive Oil Club have come to know my dear friends Filipe, his brother António, and their father Celso—now 90 and still going strong—and the story of how Celso made the delicious decision more than two decades ago to revive the centuries-old olive groves on their estates. Celso thrust Filipe into the world of extra virgin olive oil before he had any idea how the olive pressing machinery worked! As someone who loves a new challenge, Filipe had the idea to repeat this experience of on-the-job training with vinegar making.
Now 90 and still going strong, CARM founder Celso Roboredo Madeira (left) made the delicious decision well over two decades ago to revive the centuries-old olive groves on the family’s estates. Crafting red wine vinegar was the natural segue for his son Filipe (right).
“Our goal has always been to produce high-quality olive oils and wines, using only olives and grapes from our estates,” Filipe told me. “We already had a top olive oil, so we wanted to make a top vinegar to go with it, and make it ourselves from our own wine. My brother and I decided to use only Touriga Nacional grapes.” These are considered by many the finest of Portugal’s red wine grapes.
Both red wine and red wine vinegar are made by fermenting red grapes, but the vinegar requires an additional step—the second fermentation that turns the wine’s natural sugars into acetic acid. The typical aging process for red wine vinegar is two years, but Filipe had other ideas. “We wanted to do something totally different. As we went along, we decided to continue the aging process well beyond two years and ended up creating a truly remarkable product that has now been aged for 22 years in American oak barrels! Along the way, we also built our own vinegar cellar and will dedicate one of our grape vineyards to future batches of vinegar.” The natural temperature changes over its many years of aging have made this Vinagre de Touriga a well-rounded red wine vinegar, intense yet velvety as well as tart. This vinegar is exceedingly concentrated, so use it sparingly. When making dishes, add, taste, and then add a little more vinegar as desired.
Why you should have this vinegar in your kitchen: It’s marvelous in soups, stews, and other hearty dishes, like beans with chorizo and rice, and in herb-and-vinegar-based sauces and marinades. It enhances wild greens and vegetable salads and sautés, antipasto platters, and grilled cheeses.
Pure, clean, and bracing, CARM’s Vinagre de Touriga Nacional redefines red wine vinegar. I wasn’t surprised at all when took gold at a national competition in Portugal.
Quick Kitchen Nugget
Rimmed Sheet Pans
The popularity of sheet pan dinners—limitless combinations of proteins and vegetables cooked together in the oven—have made this bakeware a kitchen essential. There are almost as many options as there are recipes in which to use them. These tips will help you choose and maintain the right ones for you.
Size: Look for a “half-sheet,” a 13″ by 18″ rectangle—those dimensions are half the professional 18″ by 26″ size and will fit most home ovens. A half-sheet is big enough to hold 4 to 6 servings, depending on whether you’re making a complete main dish or a side, like roasted potatoes. You might also want to buy quarter-sheets. These measure 9″ by 13″ and work for roasting 1 or 2 servings of food.
Shape: Rimmed sheet pans are rectangles with 1″ sides so that they hold in food as well as any juices released during cooking. Look for rolled edges around the rim, easier to grip with oven mitts.
Material: Choose uncoated rimmed sheet pans made of heavy-gauge steel or aluminum. They stand up best to high heat. You can use parchment paper designed for 450°F to line your pan or sprinkle the surface liberally with extra virgin olive oil. Expect your pans to darken with use.
Care: A quick wash in hot, soapy water and a towel dry is usually all the cleaning they need. For baked-on food, soak for a few minutes before scrubbing with a brush or nonabrasive sponge.
For Your Best Health
Is Heart Disease in Your Genes?
An international team of scientists has identified nearly a dozen genes that contribute to the buildup in coronary arteries commonly known as plaque. Early plaque deposits are soft, but over time they harden into what’s called coronary artery calcification. This cholesterol-and-calcium buildup can lead to life-threatening coronary artery disease, a condition responsible for up to one in four deaths in the United States. With this new discovery, it may soon be possible to target these genes in order to slow or halt the disease’s progression.
Despite the known role of genetics in plaque buildup, only a handful of contributing genes had previously been identified. Researcher Clint L. Miller, PhD, of the University of Virginia School of Medicine’s Center for Public Health Genomics, and his collaborators identified new genetic factors that influence the risk for this buildup by analyzing data collected from more than 35,000 people of European and African ancestry around the world, the largest such meta-analysis conducted to date.
By combining several statistical analysis methods, the scientists identified more than 40 candidate genes at 11 different locations on chromosomes linked to coronary artery calcification. Eight of these locations had not been previously connected to coronary calcification at all, and five were not yet reported for coronary artery disease. Genes at these locations play important roles in determining the mineral content of our bones and regulate key metabolic pathways in the formation of calcium deposits, among other functions. The researchers also identified genes in the adenosine signaling pathway, which is known to suppress arterial calcification. The findings were published in the journal Nature Genetics.
“By sharing valuable genotype and phenotype datasets collected over many years, our team was able to uncover new genes that may foreshadow clinical coronary artery disease,” says Dr. Miller. “This is a critical first step in identifying the biological mechanisms to target for primary prevention of coronary artery disease.”
Even before people develop coronary artery disease, doctors can detect calcium buildup inside the walls of the coronary arteries using noninvasive computed tomography (CT) scans. This imaging can strongly predict future cardiovascular events such as heart attacks and strokes. Calcium accumulation is also linked to other age-related diseases, such as dementia, cancer, chronic kidney disease, and even hip fractures. “Coronary artery calcification reflects the vessel’s accumulation of lifetime exposure to risk factors,” Dr. Miller says.
While additional research needs to be done to determine how best to target these genes and affected pathways, Miller says the new discoveries could set the stage for improved risk stratification or early interventions that prevent the progression of coronary artery disease before it can take hold. Some of the promising targets may even be susceptible to dietary changes or nutrient supplementation, such as with vitamin C or D. That could be a game changer for treating a disease responsible for more than 17 million deaths annually around the world.
