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Olive Oil Hunter News #223

Summer Lentil Salad Recipe, Spotlight on Lentils, The Mediterranean Diet for IBS and Outrunning Alzheimer’s

Lentils are the unsung heroes of the legume family—high in protein and fiber along with other nutrients and fast to cook. They’re the perfect replacement for rice in summer salads and side dishes. They also fit right into the Mediterranean diet, a way of eating that could be a welcome change from the FODMAP diet for people living with IBS, according to a new study. I’m also sharing research that takes a deeper dive into exercise as a weapon in the war against Alzheimer’s.

Summer Lentil Salad

  • Summer lentil salad Summer Lentil Salad

    This protein-packed legume makes a satisfying meatless meal on its own as well as a zesty side dish for grilled tuna or salmon. 

    Ingredients

    For the lentils:

    • 1 cup dried French (du Puy) lentils
    • 3 cups homemade or low-sodium canned chicken stock, more broth or water as needed
    • 2 stalks celery, diced
    • 2 large carrots, diced
    • 1 bay leaf
    • 1 teaspoon coarse sea salt
    • 1 small red onion, diced
    • 1 large bell pepper, diced
    • 2 tablespoons finely chopped fresh flat-leaf parsley
    • Salt as desired

    For the dressing:

    • 1 tablespoon red wine vinegar, more to taste
    • 1 small shallot, minced
    • 1/8 teaspoon freshly ground black pepper
    • 1 tablespoon Dijon mustard
    • 1/4 cup extra virgin olive oil

    Directions

    Step 1

    Place the lentils in a sieve and rinse under cold running water, picking through to remove any pebbles. Bring the stock to a boil in a large pot, then add the lentils, celery, carrots, bay leaf, and salt. Turn down the heat to maintain a simmer, cover the pot, and cook until the lentils are tender but still toothsome (think al dente), about 25 minutes. Check 5 minutes in advance to make sure there’s still some liquid so that the lentils won’t scorch. If the lentils aren’t tender once the broth evaporates, add 1/2 cup more liquid and continue cooking 5-10 more minutes.

    Step 2

    While the lentils are cooking, make the dressing. In a medium bowl, mix the vinegar, shallot, black pepper, and Dijon. Slowly whisk in the olive oil. Taste and add more vinegar if desired.

    Step 3

    When the lentils are ready, strain off any remaining liquid and transfer to a large bowl; discard the bay leaf. Fold in the red onion, bell pepper, and parsley. Pour on the dressing and toss to coat. Taste and add salt as desired. Serve at room temperature or chilled.

    Yields 8 servings

Healthy Ingredient Spotlight: Lentils

Healthy Ingredient Spotlight

Let’s Hear It for Lentils

High in fiber, vitamin C, and other antioxidants, strawberries also deliver potassium, folate, and magnesium. But they also have a tendency to get moldy when moisture gets trapped between the berries, especially in typical clamshell plastic containers. A simple storage trick is to unpack them as soon as you get home and transfer them, unwashed, to a paper towel-lined glass container—line them up upside down, leaving a bit of room between them, and store in the fridge, uncovered, suggest the experts at the Utah State University Extension. Wash them just before hulling (a curved grapefruit knife works great) and blot dry with fresh paper towels.

dried lentils
Quick Kitchen Nugget: Making Lentils in Advance

Quick Kitchen Nugget

Making Lentils in Advance

With 22 grams of protein in every cup of cooked French lentils, these nutrient-dense nuggets are great to have in the fridge, ready to sprinkle on green salads, add to other side dishes, or have as a satisfying snack drizzled with olive oil. Once you’ve cooked up a batch, drain them and let them come to room temperature. Transfer to a glass container and pop into the fridge. They’ll stay fresh for up to one week.

For Your Best Health: The Mediterranean Diet for IBS 

For Your Best Health

The Mediterranean Diet for IBS 

IBS, or irritable bowel syndrome, affects an estimated 4 to 11 percent of all people, and most prefer dietary interventions to medication. Many try following the low-FODMAP diet, according to researchers at Michigan Medicine. It improves symptoms in more than half of patients, but it’s restrictive—it cuts out so many foods that people find it hard to follow. Previous investigations from these researchers, who were looking for more acceptable versions, led to their “FODMAP simple” diet, which only restricts the food groups in the FODMAP diet that are most likely to cause symptoms. Still, because any type of restrictive diets can be difficult to adopt, Michigan Medicine gastroenterologist Prashant Singh, MBBS, and his colleagues decided to look at a completely different alternative, the Mediterranean diet. 

Many physicians are already behind the Mediterranean diet because of its benefits to cardiovascular, cognitive, and general health. With so many advantages, they wanted to see whether it could also bring IBS symptom relief. “In addition to the issue of being costly and time-consuming, there are concerns about nutrient deficiencies and disordered eating when trying a low-FODMAP diet. The Mediterranean diet interested us as an alternative that is not an elimination diet and overcomes several of these limitations related to a low-FODMAP diet,” said Dr. Singh.

The Mediterranean Diet for IBS 

For the pilot study, 20 participants, all of whom were diagnosed with either IBS-D (diarrhea) or IBS-M (mixed symptoms of constipation and diarrhea), were randomized into two groups. For four weeks, one group followed the Mediterranean diet and the other followed the restriction phase of a low-FODMAP diet.

The primary endpoint was an FDA-standard 30 percent reduction in abdominal pain intensity after four weeks. In the Mediterranean diet group, 73 percent of the patients met the primary endpoint for symptom improvement versus 81.8 percent in the low-FODMAP group. Though the low-FODMAP group experienced a greater improvement measured by both abdominal pain intensity and the IBS symptom severity score, the Mediterranean diet did provide symptom relief with fewer food restrictions.

“This study adds to a growing body of evidence that suggests that a Mediterranean diet might be a useful addition to the menu of evidence-based dietary interventions for patients with IBS,” said William Chey, MD, chief of gastroenterology at the University of Michigan, president-elect of the American College of Gastroenterology, and senior author of the research paper.

Researchers found the results of this pilot study encouraging enough to warrant future and larger controlled trials to investigate the potential of the Mediterranean diet as an effective intervention for patients with IBS. They believe studies comparing the long-term efficacy of the Mediterranean diet with long-term outcomes following the reintroduction and personalization phases of the low-FODMAP diet are needed.

Fitness Flash: Outrunning Alzheimer’s?

Fitness Flash

Outrunning Alzheimer’s?

A Mass General Brigham study, published in Nature Neuroscience, has revealed how exercise rewires the brain at the cellular level. “While we’ve long known that exercise helps protect the brain, we didn’t fully understand which cells were responsible or how it worked at a molecular level,” said senior author Christiane D. Wrann, DVM, PhD, a neuroscientist and leader of the Program in Neuroprotection in Exercise at the Mass General Brigham Heart and Vascular Institute and the McCance Center for Brain Health at Massachusetts General Hospital. “Now, we have a detailed map of how exercise impacts each major cell type in the memory center of the brain in Alzheimer’s disease.”

The research team from Mass General Brigham and collaborators at SUNY Upstate Medical University leveraged advanced single-nuclei RNA sequencing (snRNA-seq), a relatively new technology that allows researchers to look at activity at the molecular level in single cells for an in-depth understanding of diseases like Alzheimer’s, along with a widely used preclinical model for Alzheimer’s disease. Focusing on a part of the hippocampus, a critical region for memory and learning damaged early in Alzheimer’s, they identified specific brain cell types that responded most to exercise. 

They exercised a common mouse model for Alzheimer’s disease using running wheels, which improved the mice’s memory compared to their sedentary counterparts. They then analyzed gene activity across thousands of individual brain cells, finding that exercise changed activity both in microglia, a disease-associated population of brain cells, and in a specific type of neurovascular-associated astrocyte (NVA), newly discovered by the team, which are cells associated with blood vessels in the brain. Furthermore, the scientists identified the metabolic gene Atpif1 as an important regulator to create new neurons in the brain. “That we were able to modulate newborn neurons using our new target genes set underscores the promise our study,” said lead author Joana Da Rocha, PhD, a postdoctoral fellow working in Dr. Wrann’s lab.

To ensure the findings were relevant to humans, the team validated their discoveries in a large dataset of human Alzheimer’s brain tissue, finding striking similarities. “This work not only sheds light on how exercise benefits the brain but also uncovers potential cell-specific targets for future Alzheimer’s therapies,” said Nathan Tucker, a biostatistician at SUNY Upstate Medical University and co-senior author of the study. “Our study offers a valuable resource for the scientific community investigating Alzheimer’s prevention and treatment.”

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Half a tablespoon of olive oil a day significantly lowered the risk of dementia-related death

Reference: Tessier A-J, Cortese M, Yuan C, et al. Consumption of olive oil and dietary quality and risk of dementia-related death. JAMA Network Open. 2024;7(5):e2410021. doi:10.1001/jamanetworkopen.2024.10021.

A recently published analysis of two large, long-term studies found that consuming half a tablespoon or more of olive oil per day lowered the risk of dying of dementia by up to 34% in both women and men. The protective effect of olive oil consumption was even greater in women.

More than 92,000 participants from the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS) were included in this analysis. The NHS started in 1976 and enrolled 121,700 female registered nurses (ages 30–55). The HPFS began in 1986 as a similar study in men, enrolling 51,525 male healthcare professionals (ages 40–75).

Study participants responded every other year to detailed food frequency questionnaires (FFQ) about their consumption of specific foods. Questions about olive oil were added in 1990. Total olive oil intake was determined by three responses: olive oil used for salad dressings, olive oil added to food or bread, and olive oil used for baking or frying at home.

Olive oil intake frequency was categorized as follows:

• Never, or less than once per month
• Less than 4.5 grams (about one teaspoon) per day
• Between 4.5 and 7 grams per day
• More than 7 grams (about half a tablespoon) per day

About two-thirds of the study participants (65.6%) were women, about a third (34.4%) were men, and the average age at the start of the study was 56 years. Each participant’s FFQs from 1990 to 2014 (or for as long as the participant remained in the study) were totaled and averaged. Average olive oil intake was 1.3 grams per day in both studies.

Participants in the highest olive oil intake group—half a tablespoon or more of olive oil per day— reduced their risk of dying of dementia by 28% to 34%, compared to study participants who never or very rarely consumed olive oil. These results were regardless of other dietary habits and factored in socio-demographic and lifestyle differences.

Deaths due to dementia were confirmed by physician’s review of medical records, autopsy reports, or death certificates of study participants.

It has been proposed that consuming olive oil may lower the risk of dementia-related death by improving blood vessel health, yet the results of this analysis were not impacted by hypertension or high cholesterol in participants.

Limitations of this analysis include its predominantly non-Hispanic white population of healthcare professionals, which reduces the ability to generalize these results across more diverse populations. Also, the FFQs did not dis-tinguish among types of olive oil, which differ in their amounts of polyphenols and other bioactive compounds.

Olive Oil Hunter News #170

Horiatiki Salad Recipe and The MIND Diet for Brain Health: More Benefits of Olive Oil

I’m a huge fan of both Greek and Middle Eastern salads, the ingredients of which are not only delicious but also mainstays of the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, a way of eating designed for brain health. It’s an offshoot of the super-healthy Mediterranean diet and the DASH (Dietary Approaches to Stop Hypertension) diet. Why the distinction? Because the latest research on the MIND diet shows it can slow aging as well as reduce dementia risk. Add this to the list of the benefits of olive oil—it’s one of the super foods that MIND suggests including every day.

Horiatiki: The Sequel!

  • Smoked Salmon Rolls Olive Oil Hunter News #257

    Smoked Salmon Rolls Recipe, Spotlight on Smoked Salmon, What Matters More Than Low Carb or Low Fat, and Exercise, a Powerful Treatment for Depression and Anxiety

    Love smoked salmon but tired of the usual bagel routine? These rollups are a snap to make and look oh so elegant! I’m also sharing an in-depth report on what makes for a better low-fat or low-carb diet when it comes to heart health. Plus, read on to learn how exercise could be an even greater game changer for anxiety and depression than previously thought.

    Smoked Salmon Rolls

    Healthy Ingredient Spotlight: Smoked Salmon Varieties

    Healthy Ingredient Spotlight

    Smoked Salmon Varieties

    Beyond traditional smoked salmon, you can now find amazing flavor varieties, such as pastrami style, everything bagel, and even Korean BBQ, from purveyors like Acme Smoked Fish and Barney Greengrass. Some are available in specialty food stores as well as online. Experiment to see what you like best!

    Smoked Salmon
    Quick Kitchen Nugget: Freezing Smoked Salmon

    Quick Kitchen Nugget

    Freezing Smoked Salmon

    You might not know that smoked salmon freezes beautifully, meaning that you can always have some on hand. The key is to freeze it as soon as you buy it to retain its freshness. You can defrost it overnight in the fridge or on the countertop in under an hour. 

    For Your Best Health: What Matters More Than Low Carb or Low Fat

    For Your Best Health 

    What Matters More Than Low Carb or Low Fat

    Published in JACC, the flagship journal of the American College of Cardiology, a decades-long study of nearly 200,000 adults challenges the low-carb versus low-fat debate. Both eating patterns were tied to lower risk of coronary heart disease (CHD) but only when they focused on nutrient-dense wholesome foods. In contrast, versions built around refined carbohydrates and animal products were associated with higher CHD risk and less-favorable metabolic health markers.

    Low-carbohydrate and low-fat eating plans are very common, yet scientists have not fully understood their long-term effects on heart health, especially when considering the quality of foods included in each pattern. This research stands out as one of the largest and most detailed investigations to date, examining participants’ diet quality, metabolomic data, and CHD risk over more than 30 years.

    “Our findings highlighted that it’s not simply about cutting carbs or fat, but it’s about the quality of foods people choose to construct those diets,” said Zhiyuan Wu, PhD, a postdoctoral research fellow at the Harvard T. H. Chan School of Public Health and lead author of the study. “The efficacy of low-carb and low-fat diets in reducing CHD risk is a topic of ongoing debate, and past studies showed mixed findings.”

    Dr. Wu noted that earlier research may have produced conflicting results because people can follow a low-carb or low-fat diet in very different ways. Some prioritize vegetables, whole grains, and healthy fats, while others rely more heavily on refined grains, processed foods, and animal-based fats. “Focusing only on nutrient compositions but not food quality may not lead to health benefits,” he said.

    The researchers’ analysis also revealed that higher-quality diets were associated with lower triglyceride levels, higher HDL cholesterol, and reduced inflammation. “These results suggest that healthy low-carbohydrate and low-fat diets may share common biological pathways that improve cardiovascular health,” Dr. Wu said. “Focusing on overall diet quality may offer flexibility for individuals to choose eating patterns that align with their preferences while still supporting heart health.”

    The researchers cautioned that the findings may not apply to more extreme dietary approaches and that the results should be interpreted within the ranges of macronutrient intake observed in the study. In addition, dietary information was self-reported, which can introduce measurement error. Because participants were health professionals with generally higher health awareness and better access to care, the findings may not fully represent the general population, although the biological mechanisms involved are unlikely to differ substantially.

    “This study helps move the conversation beyond the long-standing debate over low-carbohydrate versus low-fat diets,” said Harlan M. Krumholz, MD, editor in chief of JACC. “The findings show that what matters most for heart health is the quality of the foods people eat. Whether a diet is lower in carbohydrates or fat, emphasizing plant-based foods, whole grains, and healthy fats is associated with better cardiovascular outcomes.”

    Fitness Flash Icon: Exercise, Powerful Treatment for Depression and Anxiety

    Fitness Flash

    Exercise: Powerful Treatment for Depression and Anxiety

    A sweeping review of global research published online in the British Journal of Sports Medicinesuggests that exercise, especially aerobic activities like running, swimming, and dancing, can be one of the most powerful ways to ease depression and anxiety. Across tens of thousands of people aged 10 to 90, exercise consistently reduced symptoms, often matching or even outperforming medication and talk therapy. There are particularly strong benefits for young adults and new mothers. The analysis found that exercise done in supervised or group settings may provide the greatest benefit for people with depression. For anxiety, shorter programs lasting up to eight weeks and involving lower-intensity activity may be most helpful. These effects were seen regardless of age or sex.

    Depression and anxiety impact as many as 1 in 4 people globally, with young people and women experiencing the highest rates, according to the researchers. Earlier studies have already suggested that physical activity compares favorably with psychotherapy and medication for reducing symptoms. Still, important questions remained. It had not been fully understood how exercise works across different age groups, levels of intensity, or frequencies. In addition, many previous large reviews focused only on adults or included participants with other health conditions that could influence outcomes.

    To address these gaps, the researchers set out to evaluate how exercise affects depression and anxiety across the entire lifespan. They also examined whether factors such as exercise type, duration, frequency, intensity, and supervision, and whether it was performed individually or in groups, influenced results.

    The team searched research databases for pooled data analyses of randomized controlled trials published in English through July 2025. These trials compared structured exercise programs with other activities, a placebo, or no active treatment. Eligible studies involved planned, structured, repetitive, and purposeful physical activity intended to improve physical and mental health. All types of exercise were included, across different intensities, frequencies, and settings (individual or group).

    Group Exercise: Dance Class

    All exercise formats were linked to improvements in mental health. For depression, aerobic activity, especially when delivered in supervised or group settings, produced the largest benefits. For anxiety, aerobic, resistance, mind-body, and mixed-exercise programs, each had a medium-sized positive effect.

    The researchers acknowledge several limitations. Definitions of exercise intensity and program length varied across the pooled data analyses. There was also relatively limited pooled data examining exercise effects across every stage of life. Despite all this, they concluded, “This meta-meta-analysis provides robust evidence that exercise effectively reduced depression and anxiety symptoms across all age groups, comparable with, or exceeding, traditional pharmacological or psychological interventions.

    “Group and supervised formats gave the most substantial benefits, underscoring the importance of social factors in mental health interventions. With evidence that different characteristics of exercise appear to impact depression and anxiety at varying magnitudes, tailored exercise programs must be prescribed.

    “Given the cost effectiveness, accessibility, and additional physical health benefits of exercise, these results underscore the potential for exercise as a first-line intervention, particularly in settings where traditional mental health treatments may be less accessible or acceptable.”

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  • Smoked Salmon Rolls Smoked Salmon Rolls

    This eye-catching brunch dish gets its zesty taste from marinated cucumbers. Make them a day in advance and you’ll cut prep time to minutes.

    Ingredients

    For the marinated cucumbers:

    • 1 medium cucumber, unpeeled
    • 1 teaspoon coarse sea salt
    • 1/4 cup chopped red onion
    • 2 teaspoons chopped fresh dill
    • 2 tablespoons extra virgin olive oil
    • 2 teaspoons apple cider vinegar
    • 1 teaspoon sugar
    • 1/4 teaspoon freshly ground black pepper

    For the rolls:

    • 8 ounces thinly sliced smoked salmon, each slice about 6″ long
    • 4 ounces whipped cream cheese, at room temperature 
    • 2 scallions, coarsely chopped
    • 2 tablespoons, each, white and black sesame seeds
    • Optional garnish: fresh chives or dill 

    Directions

    Step 1

    Use the fine slicing blade of a food processor or the slicing side of a box grater to slice the cucumbers, then cut each round into matchsticks. Place in a strainer over an empty bowl and sprinkle with the coarse salt, using your hands to toss well. Let sit for 30 minutes to “sweat” the cucumbers. Rinse thoroughly to remove excess salt, then pat dry with paper towels. 

    Step 2

    Transfer the cucumbers to a large bowl and add the rest of the marinating ingredients, tossing well. Let marinate on the counter for 1 hour or up to overnight in the fridge. 

    Step 3

    To create the rolls, place a large piece of parchment paper on a cutting board. Arrange the salmon slices lengthwise in an overlapping pattern to create a rectangle that’s roughly 12″ across. Fold the scallions into the cream cheese, then spread over the salmon, using a small offset spatula to make an even layer, leaving a 1″ border. Drain the cucumber slices and place about 3/4 cup of them in a strip across the center of the cream cheese. Slowly roll up the salmon along the side closest to you, using the parchment to help form the roll. Chill the roll for 30 minutes to make slicing easier. 

    Step 4

    Use a serrated knife to cut the roll into 12 pieces. Place the sesame seeds in a small dish and roll the salmon sides of each piece in the seeds. Arrange on a platter and garnish with a small piece of chive or dill as desired. Pass the rest of the cucumbers separately.

    Serves 4

  • Shrimp with cellophane noodles Olive Oil Hunter News #256

    Shrimp with Cellophane Noodles Recipe, Spotlight on Cellophane Noodles, Shopping for Frozen Shrimp, Control Blood Pressure to Reduce Dementia Risk and The Longevity Benefits of Varied Exercise

    Looking for a change of pace for dinner? Thai cuisine boasts a wide array of flavorful dishes that are often simple to make and totally satisfying. Shrimp with cellophane noodles cooks up in under a half hour, from prep to finish. This edition’s health news includes ways to reduce dementia risk as well as to increase lifespan.

    Shrimp with Cellophane Noodles

    Healthy Ingredient Spotlight: Cellophane noodles

    Healthy Ingredient Spotlight

    Cellophane Noodles

    Cellophane noodles are an unusual type of noodle because they’re made from mung beans, sweet potato, or tapioca rather than wheat. They also go by many names, including glass noodles, bean thread, or Chinese vermicelli. While they’re generally gluten free, be sure to check labels to see whether they were made in the same facility as any gluten products to avoid any potential cross-contamination.

    The noodles come dried and should be soaked according to the recipe or package instructions before cooking. You know they’re done when they’re transparent and soft but take care not to overcook them or else they’ll become mushy. Like many types of noodles, they take on the flavors of other ingredients in a recipe, so they lend themselves to many cuisines. 

    Quick Kitchen Nugget: Shopping for Frozen Shrimp

    Quick Kitchen Nugget

    Shopping for Frozen Shrimp

    Flash-frozen shrimp

    Buying flash-frozen shrimp is a great choice because it can often be fresher than “fresh” shrimp. But there are many types of frozen shrimp available, so it’s important to be selective. First and foremost, choose wild-caught, not farm-raised, shrimp. Look for certifications from the Marine Stewardship Council (MSC) or Aquaculture Stewardship Council (ASC); these show that the shrimp were sustainably sourced, are traceable, and were harvested from healthy populations with minimal environmental impact before being individually quick frozen (or IQF)—shrimp frozen separately won’t be clumped in a block. For more convenience, look for frozen shrimp that’s already been shelled and deveined—when you buy a pound, you’re getting the full pound. A pound of shrimp with the shell nets only about 13 ounces of meat. 

    For Your Best Health: Control Blood Pressure to Reduce Dementia Risk

    For Your Best Health 

    Control Blood Pressure to Reduce Dementia Risk

    Researchers examined two known risk factors for developing dementia—one genetic and one relating to blood vessel damage in the brain. They wanted to know how much a person’s dementia risk might increase if they had both factors. In their study, published in the journal Annals of Neurology, they found that while the likelihood of developing dementia does rise if a person has both risk factors, there is a silver lining: The vascular component is within a person’s control, offering a route for minimizing dementia risk even if they have higher genetic risk.

    “Our study addressed whether these two known risk factors act additively or multiplicatively to increase the risk of incident all-cause dementia,” says senior author Adam de Havenon, MD, associate professor of neurology at Yale School of Medicine. “We wanted to show that controlling vascular risk factors like high blood pressure could prevent harmful brain changes, meaning that even those with bad genetic luck could avoid the worst outcomes.”

    The study used data from the Atherosclerosis Risk in Communities study and the UK Biobank. The team assessed two measures: white matter hyperintensity (WMH) and whether a person was a carrier of the ε4 variant of the APOE gene. WMH are lesions, or scar tissue areas, in the brain that show up as bright white spots on an MRI. They’re associated with damage to the small blood vessels in the brain, which can be caused by high blood pressure and can accumulate over time. The APOE gene encodes for a protein involved in transporting fat, such as cholesterol. When people have the ε4 variant, they carry a higher risk of developing Alzheimer’s disease.

    The researchers found that participants with both a high WMH burden and at least one APOE ε4 allele faced elevated dementia risk compared to those with neither risk factor. These effects, however, were additive rather than multiplicative, meaning each factor contributed its own risk increase rather than also exacerbating the effect of the other factor. “This tells us something really important,” Dr. de Havenon explained. “Even if you’ve been dealt a bad genetic hand with APOE ε4, you’re not destined for dementia. The vascular component is modifiable.”

    For instance, the health factors that can contribute to the development of WMH can be prevented or slowed through blood pressure management, diabetes control, and other cardiovascular interventions, he explained. “It’s really a two-hit scenario,” said Dr. de Havenon. “If you have APOE ε4 and you don’t take care of your vascular health, then you’re in a high-risk group. But having the APOE ε4 genotype is not a foregone conclusion for developing dementia later in life. Our analysis suggests that while the gene increases risk, the ultimate outcome is highly dependent on other factors. My hope is that people who find out they have this genetic mutation will be very serious about their vascular risk factors.”

    Fitness Flash Icon: The Longevity Benefits of Varied Exercise

    Fitness Flash

    The Longevity Benefits of Varied Exercise

    Weight-lifting class for improved muscle mass

    It’s well known that physical activity levels have consistently been linked with lower mortality, but there’s been limited evidence about the role of specific physical activities, each of which can have distinct benefits. What had been unclear was whether long-term engagement in multiple physical activities has additional benefits. To answer that question, an international team of researchers analyzed physical activity data that spans more than 30 years from over 111,000 participants in the Nurses’ Health Study and the Health Professionals Follow-Up Study. 

    Their study, published in BMJ Medicine, found that regularly engaging in a variety of physical activities may be the best way to prolong your lifespan. Specifically, participants with the broadest range of physical activities had a 19% lower risk of death from all causes and a 13%-14% lower risk of death from heart disease, respiratory disease, cancer, and other causes. Activities included walking, running, racquet sports, bicycling, rowing, swimming, and weight training. Only swimming couldn’t be identified as a known contributor to these results because it wasn’t possible to determine the intensity at which participants swam; further study is needed. On the other hand, the researchers confirmed the importance of weight training, a non-aerobic form of exercise that helps maintain muscle mass.

    Their findings support the notion that engaging in a diverse range of physical activity types, alongside increasing total physical activity levels, may help reduce the risk of premature death and extend lifespan, adding a crucial new dimension to the advice to stay active: Variety is just as important as volume.

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  • Shrimp with cellophane noodles Shrimp with Cellophane Noodles

    This classic Thai dish is a delicious one-pot meal that also happens to be gluten free. High-quality wild-caught frozen shrimp make a great option; let them defrost overnight in the fridge.

    Ingredients

    • 8 ounces cellophane (mung bean) noodles
    • 2 tablespoons soy sauce
    • 3 tablespoons oyster sauce
    • 1 tablespoon toasted sesame oil
    • 1 tablespoon brown sugar
    • 1 pound large shrimp, peeled and deveined
    • 1/2 teaspoon freshly ground black pepper
    • 2 cups homemade or low-sodium store-bought chicken broth
    • 2 tablespoons extra virgin olive oil, plus more for the pot
    • 1 tablespoon freshly grated ginger
    • 2 tablespoons minced garlic
    • 6 scallions, trimmed and sliced into small pieces
    • 1/3 cup each finely chopped fresh cilantro and peanuts (optional)
    • Lime wedges

    Directions

    Step 1

    Soak the noodles in a large bowl of fresh water at room temperature to soften, about 15 minutes. 

    Step 2

    In a separate bowl, whisk together the soy and oyster sauces, sesame oil, and sugar. Transfer 2 tablespoons of the mix to another bowl along with the shrimp and black pepper; toss well. 

    Step 3

    Add the broth to the bowl with the remaining soy sauce mixture.

    Step 4

    Once the noodles have softened, drain and use kitchen shears to cut the strands into thirds. Lightly brush a large Dutch oven with olive oil and heat it to medium-high heat. When hot, add the 2 tablespoons olive oil, ginger, garlic, and scallions and sauté until fragrant, about 3 minutes. Stir in the noodles and then spread out in an even layer. Top with an even layer of shrimp, drizzling on any shrimp marinade from the bowl, then slowly add the broth mixture. Turn the heat down to a simmer and cover the pot. Simmer for 10 minutes or until the shrimp and the noodles are cooked through. To serve, spoon equal amounts into deep bowls and top with cilantro and peanuts, if using, and a lime wedge.

    Yields 4 servings

  • Pecan chocolate chip cookies Olive Oil Hunter News #255

    Pecan Chocolate Chip Cookies Recipe, Spotlight on Pecans, Chilling Cookie Dough, Rethinking (Dietary) Cheating and Avoiding Falls

    Chocolate chip cookies are an American classic with hundreds of variations. My recipe adds healthy ingredients so you can feel good about indulging. Speaking of indulging, new research shows that occasional splurges don’t have to derail a smart eating plan. It turns out that your mindset matters more than the calories on your plate. Read the details below.

    Pecan Chocolate Chip Cookies

    Healthy Ingredient Spotlight: Pecans

    Healthy Ingredient Spotlight

    Pecans

    Pecans

    A high-quality source of protein with few carbs and zero cholesterol, unroasted and unsalted pecans have the American Heart Association’s Heart-Check mark to show that they meet nutritional guidelines for heart health. Pecans are rich in vitamins and minerals, including vitamin A, vitamin E, folic acid and other B vitamins, calcium, magnesium, phosphorus, potassium, and zinc, and one-and-a-half ounces of these sweet nuts deliver 15% of daily fiber needs. As part of a diet low in saturated fat and cholesterol, they may also reduce the risk of heart disease.

    Quick Kitchen Nugget: Chilling Cookie Dough

    Quick Kitchen Nugget

    Chilling Cookie Dough

    Chilling cookie dough roll

    Many types of cookies require chilling for easier rolling and cutting, but there’s another key reason for this step: richer taste and texture. This happens as the structure of the flour and sugar change over time. If you’re in a rush, allow a minimum of 30 minutes in the refrigerator, but for the tastiest results, 24 hours or more is better. In fact, cookie dough can be kept in the fridge for as long as 3 days before baking. If you’ll be storing the dough any longer than that, place it in the freezer. 

    For Your Best Health: Rethinking (Dietary) Cheating

    For Your Best Health 

    Rethinking (Dietary) Cheating

    For many people trying to lose weight, a “cheat meal” feels like a well-earned break from strict dieting—a chance to relax, enjoy something decadent, and return to routine refreshed. Eric Trexler, PhD, a fellow in the Health, Wellness, and Physical Education Department at Duke University, recently coauthored a study examining the surprisingly complicated world of cheat meals. The analysis looked at both psychological and physiological effects of loosening dietary rules and found that planned indulgences can help some people stay on track. But science also warns that unplanned or binge-like episodes may fuel guilt, shame, and unhealthy eating patterns.

    “People really overestimate the physical impact of a cheat meal and dramatically underestimate the psychological impact,” said Dr. Trexler, who conducts evolutionary anthropology research and collaborates with global health researchers at the Duke University School of Medicine. Though his doctoral research explored dietary nitrate and blood flow, he’s also examined what he calls “nonlinear dieting strategies,” an approach that intentionally includes higher-calorie days or meals during weight loss. He detailed what people misunderstand most about these meals and how mindset matters more than the calories on a plate.

    Dr. Trexler said that people tend to panic about how many pounds they’ll gain from a single cheat meal. The truth? Physically, one big dinner does almost nothing in the long term. Mentally, though, framing it as cheating can fuel guilt, shame, and the feeling that you’ve blown your diet, which can derail progress. When an indulgence is spontaneous or emotionally driven, the guilt that follows can easily snowball into overeating—turning a single cheat meal into a cheat weekend and then a cheat week. On the other hand, when a higher-calorie meal is intentional and fits within a larger eating plan, people tend to stay more motivated. Ideally, you enjoy the meal and then return to normal eating. 

    “A dietary strategy that has a lot of planned dietary deviations in place tells you, ‘You can do this,’” Dr. Trexler said. “You can implement these lifestyle changes. You don’t need to be perfect 100% of the time. You need to be good enough most of the time, and you are.”

    According to Dr. Trexler, cheat meals aren’t inherently good or bad. The key is how intentional they are, how you think about them, and what happens afterward. Instead of “cheating,” a term that suggests a moral failure, he urges people to think about planned flexibility as part of a sustainable eating pattern—one that lets you enjoy your grandmother’s caramel cake “without worrying how many eggs or cups of sugar are in it,” he said. “Eating isn’t just about nutrition. Eating is a social and cultural event. At a certain point, implemented long enough, changes become the norm. You realize you can enjoy sitting down for dessert and having one piece of cake instead of two.”

    Dr. Trexler warned of two red flags to look out for: turning one indulgence into a multiday binge and overcorrecting with extreme restriction or punishing exercise. Both patterns mirror the binge-restrict cycle common in disordered eating.

    Fitness Flash Icon: Avoiding Falls

    Fitness Flash

    Avoiding Falls

    A new study published in JAMA Ophthalmology found it’s not just that poor vision increases fall risk or that hazards increase fall risk—it’s the interaction between the two that really matters. Older adults with severe vision loss are three to four times more likely to fall when they live in homes with hazards such as missing grab bars, tripping risks like loose rugs and wires, or uneven floors.

    “The home is not just a background; it’s a key shaper of fall risk,” said lead author Shu Xu, PhD, a postdoctoral fellow at the University of Michigan’s Institute for Social Research. “Our study emphasizes the need to include the home environment as a key component of fall prevention, especially for older adults with vision loss. If we focus only on improving vision, we may overlook a group at very high risk: people who have both poor vision and hazards in their homes.”

    The population-based cross-sectional study analyzed data from the National Health and Aging Trends Study, which gathered nationally representative data on US Medicare beneficiaries age 65 and older adults living at home.

    Dr. Xu and colleagues documented that nearly half of older adults lacked grab bars in the bathroom. More than half of the sample lived with at least one hazard. Tripping hazards affected 9.5% of homes, broken flooring was present in 4.5% of them, and a total of roughly 7% of homes had two hazards.

    “When an older adult with normal vision lives in a home with multiple hazards, fall risk is relatively low, but with high levels of vision impairment, fall risk increases threefold to fourfold,” Dr. Xu said. “Importantly, even among those with high levels of vision impairment, fall risk only increases significantly when home hazards are present.”

    Incremental declines in vision directly raise fall risk for older adults with hazards in the home. Researchers measured specific visual functions and found that each one-line difference on the Snellen visual acuity chart—which tests how clearly a person can see by having them read letters of decreasing size from a set distance—was associated with a 31% increase in fall risk. Each one-line loss on the contrast sensitivity chart raised the risk by 14%.

    These rising percentages suggest that poor vision may make it harder for older adults to detect and avoid existing dangers in their homes. The findings underscore that even small losses in vision may increase risk substantially when environmental hazards are present.

    “Identifying and addressing home hazards is crucial,” said coauthor Joshua Ehrlich, MD, MPH, a professor of ophthalmology and a research associate professor at the Institute for Social Research. “Fall prevention should be framed as a partnership between health care and the physical home. In this case, vision care plus targeted home modifications.”

    Falls are a major cause of morbidity and mortality. Just one fall can be devastating for an older person. Here are some simple concrete actions to take for yourself or older loved ones:

    • Get regular eye exams and use the right glasses: Make sure prescriptions are up to date and use glasses as recommended.
       
    • Check the bathroom first: Add grab bars near the toilet and in the shower or tub; use nonslip mats in the shower or tub.
       
    • Clear walking paths: Remove or tape down loose rugs, move electrical cords out of walkways, and keep hallways and stairs free of clutter.
       
    • Fix damaged flooring: Repair torn carpet, broken tiles, or uneven floorboards that could catch a foot, cane, or walker.
       
    • Improve lighting: Use bright, even lighting, especially on stairs and in hallways; add night-lights near the bathroom and bedroom.

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  • Pecan chocolate chip cookies Pecan Chocolate Chip Cookies

    Who doesn’t love chocolate chip cookies? This recipe transforms the classic formula by replacing half the butter with extra virgin olive oil and adding nutritious whole wheat flour and pecans, which lend a nutty crunch. For best results, bake only one sheet of cookies at a time. This recipe makes a large batch. If you only need a smaller one, put one dough log in the freezer for the future. 

    Ingredients

    • 1-1/2 cups cake flour 
    • 1-1/2 cups bread flour 
    • 3/4 cup white or golden whole wheat flour 
    • 1-1/2 teaspoons baking soda
    • 1-1/2 teaspoons baking powder
    • 1 teaspoon fine sea salt
    • 6 ounces unsalted butter, softened 
    • 1-1/4 cups brown sugar
    • 1 cup sugar 
    • 2 large eggs 
    • 1/2 cup extra virgin olive oil 
    • 2 teaspoons vanilla  
    • 1 pound dark or bittersweet chocolate chunks 
    • 10 ounces pecan halves

    Directions

    Step 1

    In a large bowl, whisk together the flours, baking soda, baking powder, and salt and place next to your mixer or mixing bowl.

    Step 2

    Using a stand mixer fitted with the paddle attachment or a large bowl and a hand mixer on medium speed, blend the butter and sugars until smooth. Add the eggs, one at a time, then the olive oil and vanilla. On the lowest speed, add the flour mixture and beat until no traces of flour remain, about 20 seconds, then mix in the chocolate and pecans until evenly distributed, about another 20 seconds. 

    Step 3

    Divide the dough between two long pieces of parchment paper and shape each into a thick log, about 3 inches in diameter. Roll up each log in its parchment and tuck under the ends. Wrap each log separately in foil, then refrigerate for 24 to 48 hours.

    Step 4

    When ready to bake, preheat your oven to 350°F. Slice one log into 10 disks and transfer to a rimmed sheet pan lined with parchment. Bake on a rack in the lower third of your oven until lightly brown, about 16 minutes, rotating the pan halfway through. Repeat with the second log. Let cool for at least 10 minutes before eating and let cool completely before storing in cookie tins. 

    Yields 20 oversized cookies

  • Chicken involtini Olive Oil Hunter News #254

    Chicken Involtini Recipe, Spotlight on Chicken, A Better Approach to Losing Weight, and Why Workout Plans Go Awry

    Want to elevate your next chicken dinner? Chicken involtini, or little bundles, is the delicious answer. Stuffed with spinach and cheese, it ticks all the boxes for flavor. This issue of the newsletter also serves up two studies—one on better ways to get help for losing weight and the other on how to rethink exercise for a better chance at sticking with a plan.

    Chicken Involtini

    Healthy Ingredient Spotlight: Chicken Breasts

    Healthy Ingredient Spotlight

    Chicken Breasts

    Looking for a lean protein source? A 3-ounce serving of cooked skinless chicken breast delivers between 26 and 30 grams of protein for about 140 calories. You’ll also get B vitamins, particularly niacin and B6, and selenium, an essential trace mineral critical for supporting metabolism, among other functions.

    Cutting board and meat tenderizer
    Quick Kitchen Nugget: Pounding Chicken

    Quick Kitchen Nugget

    Pounding Chicken

    Pounded cutlets cook quickly and evenly because they have a uniform thickness. What’s more, pounding provides a bigger surface for stuffing which also makes rolling them up easier. It’s important to use a surface that can be easily and thoroughly cleaned, even though you’ll be pounding the chicken between sheets of parchment paper.

    A meat mallet is a great tool; the flat side can be used on chicken and pork cutlets, and the side with the little spikes helps tenderize tougher cuts of beef. However, you can also make do with a heavy pan or even a rolling pin. Make sure to rotate the cutlet so you apply the force uniformly and not just to one or two spots. Start with moderate force and increase only if necessary to get an even thickness. 

    For Your Best Health: A Better Approach to Losing Weight

    For Your Best Health 

    A Better Approach to Losing Weight

    For a long time, endocrinologist Leigh Perreault, MD, felt uneasy about how weight management was handled in routine medical care. Too often, patients were sent home with vague advice to eat better and exercise more, even when that clearly was not enough.

    “There was a moment I put my face in my hands and thought, ‘What am I doing?’ I would write a lot of prescriptions for patients’ diabetes, their blood pressure, their lipids, and all these other conditions,” said Dr. Perreault, a professor of endocrinology, metabolism, and diabetes at the University of Colorado Anschutz School of Medicine who practices in Westminster, Colorado, alongside primary care physicians. But she realized that many of those medications addressed symptoms rather than the root problem. “None of these people want to be on these medications, and I thought if I could just help them with their weight, many of these health concerns would probably go away,” she said. That realization set the stage for a new approach that could soon reshape how weight care would be addressed in primary care.

    Dr.Perreault and her colleagues created PATHWEIGH, a structured process that helps people and their primary care teams focus directly on weight management. The program introduces dedicated clinic visits where providers can concentrate specifically on weight-related care instead of squeezing it into a standard appointment.

    With funding from the National Institutes of Health, PATHWEIGH was rolled out across UCHealth’s 56 primary care clinics throughout Colorado to evaluate its impact. The pilot included 274,182 patients, making it one of the largest randomized trials ever conducted in this area. Results published in Nature Medicine showed that the program reduced population weight gain by 0.58 kg (about one and a quarter pounds) over 18 months and shifted the overall trend from steady gain to weight loss. Experts estimate that rising obesity rates are driven by an average population weight gain of about 0.50 kg or roughly a half pound every year. Stopping that increase and turning it into even modest weight loss could make a meaningful difference in slowing the obesity epidemic. “While it’s not a significant difference on an individual patient level, it’s a huge deal on a population and public health level,” Dr. Perreault said.

    The program also made patients more likely to get help for weight issues. Participation increased the chances of receiving weight-related care by 23%. Most of that care involved lifestyle counseling, but prescriptions for anti-obesity medications doubled during the intervention. Unlike many one-size-fits-all weight-loss programs, PATHWEIGH allows treatment to be customized to each patient. It also reduces the discomfort that often surrounds conversations about weight in medical settings.

    “With PATHWEIGH, we showed that we absolutely eliminated population weight gain across all of our primary care, which had never been done previously,” Dr. Perreault said. “If you think about weight loss medicine or surgery or a weight loss program, those are all vehicles to weight loss. We built a highway that we could put all the vehicles on, so there’s actually a process for people to receive weight-related care if they want it.

    Dr. Perreault said the program’s success has opened the door to wider adoption. Plans are underway to expand PATHWEIGH beyond Colorado. The Obesity Association, which is developing its first standards of care for obesity, is highlighting the program as a recommended care process. Five health systems across seven states are also considering PATHWEIGH as its creators work toward licensing the model.

    Fitness Flash Icon: Why Workout Plans Go Awry 

    Fitness Flash

    Why Workout Plans Go Awry

    You know you should exercise, so you make a solid plan to do it, but then, in the decisive moment, you opt out. And then you choose to forgo your planned daily exercise again and again. Why? It could be related to what scientists call all-or-nothing thinking.

    “Most people are tired and overwhelmed, so in the moment of decision, the immediate costs of exercising feel much bigger than the benefits, making it a low-value choice,” said University of Michigan behavioral scientist Michelle Segar, PhD. “This makes doing ‘nothing’ a prudent choice and desirable exit strategy. Decisions to not exercise are often made outside of awareness—so people are likely unaware that choosing to forgo their exercise plans could be related to having an all-or-nothing mindset.” 

    She suggests that all-or-nothing thinking is caused by a deeply embedded mindset that leads many people to abandon their exercise plans. “Exercise-related all-or-nothing thinking occurs when a specific exercise plan becomes unworkable,” Dr. Segar explained. “At this moment, when people cannot perfectly adhere to their plan—the ‘all’—they choose not to exercise at all rather than modify the plan.”

    While all-or-nothing thinking has been studied in relation to eating and weight, this is the first in-depth research to investigate this phenomenon with exercise, Dr. Segar said. She and her colleagues Jen Taber, John Updegraff, and Alexis McGhee-Dinvaut, all of Kent State University, conducted four focus groups among 27 adults—ages 19 to 79—who tried to exercise but couldn’t stick with it. The study, published in BMC Public Health, uncovered four components that collectively make up an all-or-nothing mindset:

    • Having rigid, idealized criteria for exercising. For most participants, their “all” constituted rigid standards that had to be met to exercise “right.” They typically say to themselves, “If I do something for under 15 minutes, I feel like I didn’t even exercise. Even if it were dead-out sprints, it just doesn’t factor into my head like I did anything.”
    • Seeking excuses for not exercising. This component reflects participants actively trying to avoid their intended exercise. They said that exercising the right way took a lot of effort, saying, “It’s hard,” “It hurts,” and “It doesn’t feel good to do.”
    • Believing exercise was expendable compared to their daily priorities. Participants said things like “When your routine ends up getting crowded with the things that have to be done or should be done, [exercising] is an easy thing to push to the side.”
    • Being baffled about why they could not stick with exercise. Participants were unable to reconcile their current inactivity even though they could recall having had previous positive experiences exercising, saying things such as “I don’t understand why I don’t exercise. … I’m an educated woman… why can’t I even make a dent in it?”

    “The all-or-nothing mindset creates high costs for exercising,” said Dr. Segar. Here’s her advice to overcome it:

    • Don’t be a prisoner to your exercise past. Know that negative exercise experiences in your past can demotivate you now. Acknowledge that fact and then move forward in more positive and realistic ways.
    • Don’t blame yourself for not sticking with exercise. Our culture has taught us an exercise formula that sets up most people to fail.
    • Choose “good enough” over “perfect.” Nothing has to be perfect, including exercise.

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  • Chicken involtini Chicken Involtini

    These stuffed boneless chicken breasts are browned on the stovetop and then baked in the oven in an olive oil, lemon, and butter sauce. Enjoy on its own or over pasta.

    Ingredients

    • 7 tablespoons extra virgin olive oil, divided use
    • 4 garlic cloves, finely chopped
    • 12 ounces fresh baby spinach
    • 1 teaspoon salt, divided use
    • 1 teaspoon freshly ground black pepper, divided use
    • 1/4 teaspoon crushed red pepper flakes
    • 4 skinless boneless chicken breasts, about 2 pounds in total
    • 8-ounce block Emmenthaler or provolone cheese, sliced into 8 sticks 
    • 1/3 cup whole wheat flour 
    • 1-1/2 cups homemade or store-bought low-sodium chicken stock
    • Juice of half a lemon
    • 2 tablespoons butter, cut into pieces
    • 1/4 cup fresh flat-leaf parsley, finely chopped

    Directions

    Step 1

    Heat a large oven-safe skillet over medium-high heat. When hot, add 3 tablespoons olive oil and the garlic. Cook the garlic until it becomes translucent, then add the spinach in bunches. As each bunch wilts, add the next. When completely wilted and tender, transfer to a colander and set the skillet aside. Let the spinach cool for 5 minutes, then squeeze with your hands to remove any excess liquid. Transfer to a large glass bowl and toss with 1/2 teaspoon salt, 1/2 teaspoon black pepper, and the red pepper flakes. 

    Step 2

    Slice each breast horizontally to make eight cutlets. One at a time, place each cutlet between two sheets of parchment paper set on a cutting board, and use a kitchen mallet to pound it to about 1/4” thickness. Season each cutlet with the remaining salt and pepper. 

    Step 3

    Top each cutlet with a layer of spinach, then place a stick of cheese in the center. Starting at the narrow end, roll up each cutlet and secure with a wooden skewer or toothpicks to keep the roll closed.

    Step 4

    Preheat your oven to 375°F. Put the flour in a pie plate and place it next to your stovetop. Wipe out the skillet and reheat it. When hot, add 4 tablespoons olive oil. Roll each bundle in the flour, shake off any excess, and add to the pan, seam side down. Brown on all sides, turning with heat-safe tongs. Deglaze the skillet with the stock, then add the lemon juice and butter. Place the skillet in the oven for 20 minutes or until an instant read thermometer placed in the chicken shows 160°F. 

    Step 5

    Very carefully take the pan out of the oven. If you’d like a thicker sauce, plate the chicken and return the skillet to the stovetop. Bring to a boil and cook down for about 5 minutes. To serve, remove the skewers or toothpicks, drizzle on some sauce, and sprinkle on the parsley.

    Yields 4 servings

  • baked ziti Olive Oil Hunter News #253

    Baked Ziti Recipe, Spotlight on Whole Wheat Pasta, Understanding al Dente, How the Nose Fends Off Colds and Fighting Age-Related Muscle Loss

    When it comes to comfort food, few dishes can top baked ziti, with its luscious sauce and melted cheeses. And it doesn’t take much effort for all that reward! I’m sharing interesting research that may explain why some people are more prone to colds than others as well as a reminder about maintaining muscle as we age.

    Baked Ziti

    Healthy Ingredient Spotlight: Whole Wheat Pasta

    Healthy Ingredient Spotlight

    Whole Wheat Pasta

    To add more nutrients and fiber to your ziti, opt for whole wheat pasta. It’s made from the entire wheat kernel—bran, germ, and endosperm—and retains its vitamins and minerals. While it takes a bit longer to cook, follow package directions to be sure it’s al dente.

    Quick Kitchen Nugget: Understanding al Dente

    Quick Kitchen Nugget

    Understanding al Dente

    Ziti pasta al dente

    Al dente literally means to the tooth—firm when bitten yet not hard or raw tasting. Most Italian cooks boil pasta to this stage regardless of the recipe. Americans tend to like their pasta more tender. But when it will be twice cooked, as with ziti, lasagna, and stuffed shells, it needs to be al dente before it goes into the oven or else it will be too soft.

    If your pasta box doesn’t list al dente cooking time, test a piece about 2 minutes sooner than the general directions and see whether it has a bit of bite. If it’s too firm, check it again in a minute. 

    For Your Best Health: How the Nose Fends Off Colds

    For Your Best Health 

    How the Nose Fends Off Colds

    When rhinovirus, the most common cause of the common cold, enters the nasal passages, the cells lining the nose immediately begin working together to fight the infection. These cells activate a wide range of antiviral defenses designed to limit the virus and stop it from spreading. In a study published in the journal Cell Press Blue, researchers show that this early response plays a key role in whether a person becomes sick and how severe their symptoms become. The findings suggest that the body’s reaction to rhinovirus often matters more than the virus itself.

    “As the number one cause of common colds and a major cause of breathing problems in people with asthma and other chronic lung conditions, rhinoviruses are very important in human health,” said senior author Ellen Foxman, MD, PhD, of the Yale School of Medicine. “This research allowed us to peer into the human nasal lining and see what is happening during rhinovirus infections at both the cellular and molecular levels.”

    To closely observe how nasal cells respond to infection, the research team built a lab-grown model of human nasal tissue with multiple cell types found in the human airway, including mucus-producing cells and cells with cilia, the tiny hairlike structures that help move mucus and trapped particles out of the lungs. “This model reflects the responses of the human body much more accurately than the conventional cell lines used for virology research,” Dr. Foxman said.

    Using this model, the researchers were able to monitor how thousands of individual cells respond together during infection. They also examined what happened when the cellular sensors responsible for detecting rhinovirus were blocked. These experiments revealed a powerful defense system coordinated by interferons, which are proteins that interfere with viral entry and replication.

    When nasal cells detect rhinovirus, they release interferons that activate antiviral defenses not only in infected cells but also in nearby healthy cells. This coordinated response makes it difficult for the virus to reproduce and spread. If interferon activity begins quickly, the infection can be contained early. When the researchers blocked this response, the virus spread rapidly, infecting many more cells and causing significant damage. In some cases, the infected organoids did not survive.

    “Our experiments show how critical and effective a rapid interferon response is in controlling rhinovirus infection, even without any cells of the immune system present,” said first author Bao Wang, PhD, of the Yale School of Medicine.

    The study also uncovered additional responses that occur when viral replication increases. Under these conditions, rhinovirus can activate a separate sensing system that leads both infected and uninfected cells to produce large amounts of mucus and inflammatory signals. This reaction can contribute to airway inflammation and breathing difficulties in the lungs. According to the researchers, these pathways may offer useful targets for treatments aimed at reducing harmful symptoms while supporting effective antiviral defenses.

    “Our study advances the paradigm that the body’s responses to a virus, rather than the properties inherent to the virus itself, are hugely important in determining whether or not a virus will cause illness and how severe the illness will be,” Dr. Foxman said. “Targeting defense mechanisms is an exciting avenue for novel therapeutics.”

    Fitness Flash Icon: Fighting Age-Related Muscle Loss 

    Fitness Flash

    Fighting Age-Related Muscle Loss 

    A new study in mice is giving scientists fresh clues about why our muscles lose strength as we get older and why exercise remains one of the most reliable ways to fight it.Researchers at Duke-NUS Medical School found that a gene regulator called DEAF1 seems to push a key muscle-maintenance system into overdrive as we age. When we’re young, the system known as mTORC1 helps build and repair muscle. But later in life, it can get stuck in high gear and begin to damage muscle cells instead.

    “The mTORC1 pathway is essential for muscle growth yet becomes chronically overactive in aging—a paradox that has made it challenging to pinpoint what drives this dysregulation,” said the study’s senior author Hong-Wen Tang, PhD, an assistant professor in the Cancer and Stem Cell Program at Duke-NUS and Singapore General Hospital.

    Until now, scientists didn’t know what caused this shift. “Identifying DEAF1 fills an important gap in understanding how age-related stress signals become hardwired into a persistent anabolic state that ultimately harms muscle cells,” Dr. Tang said.

    The study suggests DEAF1 essentially hits the gas on a system already running too fast. By pushing mTORC1 into overdrive, DEAF1 causes muscles to make too many proteins, fail to clear damaged ones, and gradually weaken.

    Seniors weight-lifting outdoors

    One of the most surprising findings: Exercise reverses this process by lowering DEAF1 levels. That means in addition to building muscle, physical activity helps reset the core cellular pathways that keep muscles healthy. “It was a striking discovery,” said Dr. Tang. “It shows that exercise doesn’t just fix damage; it targets the switch that causes muscle aging in the first place.”

    Scientists didn’t just look at whether exercise keeps muscles strong—they wanted to know how it does it. They put aging mice through endurance workouts, including an exhausting treadmill run. For comparison, another group of older mice stayed sedentary. After the workouts, the exercising mice showed big drops in mTORC1, the overactive pathway linked to muscle loss and function known as sarcopenia.

    Researchers found that exercise lowers DEAF1 through a well-known set of longevity genes called FOXO. When activated during exercise, FOXO suppresses DEAF1—lifting the foot off the gas pedal—and helps mTORC1 return to normal. Their work highlights a new biological pathway—the FOXO-DEAF1-mTORC1 axis—that helps explain why muscles weaken with age and why exercise remains such a powerful antidote to age-related decline. 

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  • baked ziti Baked Ziti

    This delectable dish starts with a rich yet quick tomato sauce. You can substitute a 15-ounce can of diced tomatoes with their juice for the fresh tomatoes but add it after the tomato paste. 

    Ingredients

    • 3 tablespoons extra virgin olive oil, plus more for the baking dish and drizzling
    • 2 garlic cloves, chopped
    • 1 pound tomatoes, any type, coarsely chopped
    • One 6-ounce can tomato paste
    • 1 teaspoon sugar
    • 1 teaspoon fine sea salt
    • 1/2 teaspoon crushed red pepper flakes, plus more to taste
    • 1/2 teaspoon freshly ground black pepper
    • 1 pound ziti
    • 16 ounces ricotta cheese
    • 12 ounces mozzarella, thinly sliced
    • 1/3 cup freshly grated Parmigiano-Reggiano cheese

    Directions

    Step 1

    Brush a 13-inch by 9-inch baking dish with olive oil; set aside.

    Step 2

    Heat a medium saucepan over medium heat. When hot, add the 3 tablespoons olive oil and garlic and sauté for 3 minutes, then add the tomatoes. Cook, stirring constantly, until the tomatoes become soft, then push them to the outsides of the pan. Add the tomato paste and cook it until it becomes fragrant and darkens in color, about 5 minutes. Mix the paste with the tomatoes and garlic, then press with a masher to release all of the tomatoes’ juices. Stir in the sugar, salt, and both peppers and continue cooking for 10 minutes.

    Step 3

    Meanwhile, preheat your oven to 350°F. Cook the ziti according to the package directions until al dente, then drain. 

    Step 4

    Off the heat, stir the ricotta into the sauce, then fold in the pasta. Transfer the mixture to the baking dish. Top with overlapping slices of mozzarella, then sprinkle on the grated cheese.

    Step 5

    Bake for 25 minutes, until the cheeses are bubbly. Cool for 10 minutes before serving.

    Yields 8 servings

For Your Best Health: Managing Depression: Using Scents to Unlock Memories 

For Your Best Health

The MIND Diet for Brain Health: More Benefits of Olive Oil

According to a new study from researchers at the Columbia University Mailman School of Public Health and The Robert Butler Columbia Aging Center, a very specific brain-boosting diet has been linked to reduced dementia risk and a slower pace of aging. The study, “Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study,” published in the Annals of Neurology, also explains how the diet helps slow down the processes of biological aging.

“Much attention to nutrition in dementia research focuses on the way specific nutrients affect the brain,” said Daniel Belsky, PhD, associate professor of epidemiology and a senior author of the study. “We tested the hypothesis that healthy diet protects against dementia by slowing down the body’s overall pace of biological aging.”

The researchers used data from the second generation of the Framingham Heart Study, the Offspring Cohort. Participants were 60 years of age or older and free of dementia and had available dietary, epigenetic, and follow-up data. Follow-up was done at nine examinations, approximately every 4 to 7 years, which included a physical exam, lifestyle-related questionnaires, blood sampling, and, starting in 1991, neurocognitive testing. Of 1,644 participants included in the analyses, 140 developed dementia. 

To measure the pace of aging, the researchers used an epigenetic clock called DunedinPACE developed by Dr. Belsky and colleagues at Duke University and the University of Otago in Dunedin, New Zealand. The clock measures how fast a person’s body is deteriorating as they grow older, “like a speedometer for the biological processes of aging,” explained Dr. Belsky.

“We have some strong evidence that a healthy diet can protect against dementia,” said Yian Gu, PhD, associate professor of neurological sciences at Columbia University Irving Medical Center and the other senior author of the study, “but the mechanism of this protection is not well understood.” Past research linked both diet and dementia risk to an accelerated pace of biological aging. “Testing the hypothesis that multi-system biological aging is a mechanism of underlying diet-dementia associations was the logical next step,” explained Dr. Belsky.

The research determined that higher adherence to the MIND diet slowed the pace of aging as measured by DunedinPACE and reduced risks for dementia and mortality. Furthermore, slower DunedinPACE accounted for 27% of the diet-dementia association and 57% of the diet-mortality association.

“Our findings suggest that slower pace of aging mediates part of the relationship of healthy diet with reduced dementia risk, and therefore, monitoring pace of aging may inform dementia prevention,” said first author Aline Thomas, PhD, of the Columbia Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. “However, a portion of the diet-dementia association remains unexplained, therefore we believe that continued investigation of brain-specific mechanisms in well-designed mediation studies is warranted.”

“We suggest that additional observational studies be conducted to investigate direct associations of nutrients with brain aging, and if our observations are also confirmed in more diverse populations, monitoring biological aging may indeed inform dementia prevention,” noted Dr. Belsky.

Exactly What Is the MIND Diet?

MIND is a hybrid of the Mediterranean and DASH diets, tailored to reflect key findings from nutrition and dementia research. It details serving sizes of specific foods to focus on and which to limit, primarily those high in saturated fat, which is known to negatively affect brain health. 

Foods and portions to eat every day: 1/2 to 1 cup green leafy vegetables, 1/2 cup other vegetables, 2 tablespoons extra virgin olive oil, and three 1-ounce servings of whole grains. 

Foods and portions to eat over the course of each week: 5 ounces nuts, 2-1/2 cups berries, 1-1/2 cups legumes, two 3-to-5-ounce servings of skinless poultry, and 3-to-5 ounces fish.

Foods to limit to these weekly totals: three or fewer 3-to-5-ounce servings of red and processed meats, 1 ounce whole-fat cheese, 1 fried or fast food, and 4 sweet servings. If desired, no more than 1 teaspoon of butter or stick of margarine a day.

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Olive Oil Hunter News #163

Mini Pistachio Thumbprint Cookies Recipe, For Your Best Health: The Mediterranean Diet (Still No. 1)

Among the most important news items I share in this newsletter are results of scientific studies on the benefits of olive oil and, in a larger context, the Mediterranean diet. I love to report on research that shows how this way of eating—and living—has positive impacts on heart and brain health and can help ward off serious chronic diseases including diabetes and dementia. 

It’s also rewarding to see how the diet has been adopted here in the US and how many of our esteemed institutions, such as the American Heart Association and the Cleveland Clinic, recommend it. An annual survey that so many people appreciate reading is the U.S. News & World Report’s ranking of dietary plans or “Best Diets.” And for the seventh year in a row the Mediterranean diet triumphs in the top spot. I’ll detail the highlights of the magazine’s reasoning right after this delicious recipe for cookies you can enjoy guilt-free—in moderation, of course.

Mini Pistachio Thumbprint Cookies

  • Pistachio thumbprint cookies Mini Pistachio Thumbprint Cookies

    With a minimal amount of sugar, these cookies pack all the heart-healthy benefits of nuts, a key food—along with extra virgin olive oil—of the Mediterranean diet. Though sweets are the smallest food group on the Mediterranean diet food pyramid, we know that an occasional treat can help us stay on track with this healthful way of eating. This recipe shows that you don’t have to make huge sacrifices to enjoy it.

    Ingredients

    • 1 cup shelled pistachios
    • 1-1/2 cups almond flour
    • 1/2 cup granulated sugar
    • 2 large egg whites
    • 1/4 teaspoon sea salt
    • 2 tablespoons extra virgin olive oil
    • 1/2 teaspoon almond extract
    • 1 teaspoon vanilla extract or paste
    • 1/4 cup raspberry or apricot all-fruit (no sugar added) preserves, such as Polaner or St. Dalfour

    Directions

    Step 1

    Preheat your oven to 350°F. Line two rimmed sheet pans with parchment paper. Use a spice or coffee bean grinder to pulverize the pistachios (you may need to do this is batches). Transfer to a large bowl along with the almond flour and sugar, and mix thoroughly.

    Step 2

    In a stand mixer or large bowl with a hand mixer, beat the egg whites and salt at a low speed until frothy, then increase the speed and beat until you get soft peaks. Briefly whip in the olive oil and the extracts. Fold the whites into the nut mixture with a large spatula until fully combined. The dough will be very firm.

    Step 3

    Using a 1-inch ice cream scoop or melon baller, make dough balls and evenly space them on the parchment-lined pans. Use your thumb to make an indentation in the top of each cookie, flattening the centers and then filling each with a half-teaspoon or so of preserves.

    Step 4

    Bake just until set, about 15 minutes, rotating the pans halfway through. Wait 5 minutes before transferring the cookies to a rack to cool. When completely cooled, store in an airtight tin. 

    Yields about 44 cookies

For Your Best Health: The Mediterranean Diet is Still No. 1

For Your Best Health

The Mediterranean Diet: Still No. 1

According to the U.S. News & World Report 2024 rankings, created in partnership with The Harris Poll and with input from a panel of leading health experts, the Mediterranean diet has once again taken the No. 1 spot in the Best Diets Overall category, thanks to its focus on diet quality and primarily plant-based foods. The Mediterranean diet also claimed the top spot in the categories Best Diets for Diabetes, Best Heart-Healthy Diets, Easiest Diets to Follow, Best Diets for Bone and Joint Health, Best Family-Friendly Diets, and Best Diets for Healthy Eating, and the No. 2 spot in the Best Weight Loss Diets and the Best Plant-Based Diets categories. 

One of the reasons it’s both adoptable and adaptable is that there are so many cuisines to choose from when looking for recipes. Dishes that are popular in Turkey and Greece will offer different tastes than those from Italy, France, or Spain or from Morocco and other North African countries. But the unifying elements are the same: the emphasis on vegetables, fruits, extra virgin olive oil, nuts, whole grains, legumes, herbs, spices, and other plant-based foods that leave you feeling satisfied; minimal food processing; and a convivial atmosphere in the kitchen and at the table. 

The Mediterranean diet also ranks high for what it leaves out:saturated fat, added sugars, and excess salt—all so prevalent in the typical American diet and so likely to leave you wanting more because foods with a low-nutrient profile are not truly satisfying. Eating them regularly also poses health risks. Eating a Mediterranean-style diet, on the other hand, translates to a longer life, a higher quality of life, and a lower risk of chronic diseases such as cancer, dementia, and heart disease.

The Mediterranean diet food pyramid is a great way to visualize the foods to focus on and how often to eat them. Whole grains, legumes, vegetables, fruit, and olive oil make up most of your daily intake. Seafood can be enjoyed a few times a week; animal proteins like poultry, eggs, cheese, and yogurt less often; and red meat less often still. But you also have a lot of leeway, so you don’t need to feel guilty about eating foods not on the pyramid. Nothing is totally eliminated, though you’re advised to eat foods like sugary desserts, butter, heavily processed foods like frozen meals, candy, and refined grains and oils sparingly.

Mediterranean Food Pyramid with Olive Oil and recommended servings
Mediterranean Food Pyramid

To get started on the Mediterranean diet, or to more closely follow it, U.S. News & World Report suggests these tips:

  • Think of meat as your side dish and whole grains or vegetables as your main dish. 
  • Look beyond Greek and Italian cuisines for inspiration—in all, 22 countries border the Mediterranean Sea!
  • As with any diet, do some advance meal planning so you won’t be tempted by convenience foods after a long day at work. For instance, cook up a batch of grains or lentils on the weekend to use for meals throughout the following week.
  • Make water your main source of hydration. Wine is considered optional and then only in moderation—one to two glasses per day for men and one glass per day for women.

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