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Dementia: Olive oil could help protect brain health, according to new study

Posted on by The Olive Oil Hunter

Adapted from the original research and an article by Robby Berman in Medical News Today, August 2, 2023

Consuming half a tablespoon of olive oil per day could substantially lower your risk of dying from dementia, a new study shows.

According to a presentation on July 24 at the NUTRITION 2023 conference in Boston, the study found that people who consumed half a tablespoon or more of olive oil daily had a 25% reduced risk of dying from dementia compared to people who did not consume olive oil.

What’s more, higher olive oil intake was linked to greater brain benefits. “We found a clear linear dose-response association between higher daily olive oil intake and lower risk of fatal dementia,” said presenter Anne-Julie Tessier, RD (registered dietician), PhD, a postdoctoral fellow at the Harvard T. H. Chan School of Public Health.

This US-based study is the first to investigate the relationship between diet and dementia-related death. The investigators analyzed the health records from 1990 to 2018 of more than 90,000 people in the US who did not have cardiovascular disease or cancer at the start of the study. During the study’s 28 years of follow-up, 4,749 participants died from dementia.

Replacing even a single teaspoon of margarine or commercial mayonnaise with olive oil was also associated with a 5-12% reduced risk of dying from dementia, according to the research team. These benefits were not seen with other vegetable oils.

The link between higher olive oil intake and lower risk of dying of dementia was observed regardless of the overall quality of people’s diets. This may indicate that components of olive oil provide unique benefits for brain health.

“Some antioxidant compounds in olive oil can cross the blood-brain barrier, potentially having a direct effect on the brain,” said Dr. Tessier. “It is also possible that olive oil has an indirect effect on brain health by benefiting cardiovascular health.” She noted that only a few individuals in the study consumed more than 15 mg (about 1 tablespoon) of olive oil daily.

A body of previous research has established an association between olive oil intake and a lower risk of heart disease, and incorporating olive oil as part of the Mediterranean diet has also been shown to help protect against cognitive decline.

Dr. Tessier reflected on the characteristics of olive oil that may confer its effects on the brain: “Olive oil may play a beneficial role in cognitive health through its rich content in monounsaturated fatty acids, which may promote neurogenesis [growth of brain cells]. It also contains vitamin E and polyphenols that have antioxidant activity.”

The research team advised that an observational study such as this is only able to identify an association and does not prove that olive oil is the cause of the reduced risk of dying from dementia. Randomized, controlled trials are needed to confirm the study’s findings and to help establish the optimal quantity of olive oil to consume in order to experience the most benefits.

Reference: Tessier JA, Yuan C, Cortese M, et al. Olive oil and fatal dementia risk in two large prospective US cohort studies. Poster presented at NUTRITION 2023 conference, Fairfax, VA, July 24, 2023.

Olive oil is shown to improve brain health and memory in individuals with mild cognitive impairment

Posted on by The Olive Oil Hunter

Adapted from an article by Matt Crouch, Auburn University (auburn.edu), March 6, 2023

Extra virgin olive oil may have positive effects on individuals with mild cognitive impairment, according to a recently completed study published in the journal Nutrients. The study’s findings suggest that compounds found in olive oil positively affect brain health and help improve the blood-brain barrier.

In the study, 25 adult participants experiencing mild cognitive impairment consumed 30 ml (about three tablespoons) of olive oil per day for six months. Thirteen of the participants consumed extra virgin olive oil (EVOO) and 12 consumed refined olive oil (ROO), as a control group. EVOO is rich in phenols, while ROO has been purified of phenols.

Study participants took several tests before and after consuming olive oil, including MRI scans, cognitive tests, and blood analysis to measure biomarkers related to Alzheimer’s disease.

This study evaluated the blood-brain barrier and its permeability—the degree to which it protects the brain. The blood-brain barrier, a network of blood vessels and tissue made up of closely spaced cells, plays a vital role in maintaining a healthy brain by protecting the brain from exposure to blood-related neurotoxins and in the clearance of brain waste products.

The study also measured levels of beta-amyloid and tau, two proteins associated with Alzheimer’s disease. In people with Alzheimer’s disease, levels of beta-amyloid and tau are increased.

The benefits of olive oil consumption were more pronounced in the EVOO group, but participants in the ROO group experienced improvements as well: Both EVOO and ROO improved cognitive function, as determined by the improved clinical dementia rating and other behavioral scores. Additionally, “our findings showed that EVOO and ROO altered two major biomarkers related to Alzheimer’s disease,” said Kaddoumi. “These alterations collectively could have played a role in improving the blood-brain barrier and improving function and memory.”

This study in individuals with mild cognitive impairment is the first to evaluate what happens to the human brain as a result of consuming olive oil.

“These results are exciting because they support the health benefits of olive oil against Alzheimer’s disease,” said Kaddoumi. “Based on the findings of this study and previous preclinical studies… we can conclude that adding olive oil to our diet could maintain a healthy brain and improve memory function.”

Reference: Kaddoumi A, Denney TS, Deshpande G et al. Extra-virgin olive oil enhances the blood-brain barrier function in mild cognitive impairment: a randomized controlled trial. Nutrients. 2023;14(23):5102. doi.org/10.3390/nu14235102.

Yale Symposium Discusses Olive Oil’s Many Health and Planetary Benefits

Posted on by The Olive Oil Hunter

Adapted from an article by Colin Poitras, September 21, 2022

Leading experts involved in research and education related to the olive tree and its products gathered in Rome recently to discuss the positive health benefits of olive oil during the Fourth Annual Yale Symposium on Olive Oil & Health, September 15–18, 2022.

Organized by Vasilis Vasiliou, PhD, and Tassos C. Kyriakides, PhD, of the Yale School of Public Health, the four-day symposium addressed a variety of themes central to olive cultivation and the future of olive oil as it pertains to human and planetary health.

Laura Di Renzo, of the University of Rome Tor Vergata, focused attention on the role of high-quality extra-virgin olive oils in preventing non-communicable chronic degenerative diseases (NCDDs) and the health benefits of a sustainable Mediterranean diet. NCDDs include obesity, cardiovascular disease, diabetes, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, chronic respiratory diseases, and many cancers. They have been the most frequent causes of prolonged disability and death worldwide.

Di Renzo highlighted the role of the sustainable Mediterranean diet in the prevention and treatment of NCDDs, including the antioxidant and anti-inflammatory effects of extra virgin olive oil (EVOO).

Attendees praised the symposium for helping to raise awareness of the health benefits of olive oil. Vasiliou and Kyriakides have been leading international advocates for the promotion of olive oil as an important part of a healthy diet.

Kyriakides, an olive oil sommelier, not only constantly tastes oils from all over the world, he consumes copious amounts of olive oil daily in his cooking in addition to his daily morning extra virgin olive oil shot.

It’s a delicious natural and healthfully nutritious food. The olive tree and olive oil have been bringing people together for thousands of years; as public health professionals it is our task to maintain and safeguard the olive tree and its numerous positive effects on human and planetary health. The olive tree can serve as a vehicle in our pursuit for sustainable and planet-friendly agricultural practices.

—Tassos C. Kyriakides, PhD, of the Yale School of Public Health

Evidence accumulated over the past six decades shows that olive oil promotes good health, Kyriakides said. A daily intake of 20 grams of olive oil (about two tablespoons) contains a polyphenol (at least 5 mg of hydroxytyrosol and its derivatives) that assists in the protection of blood lipids from oxidative stress. The finding has been supported by the European Food Safety Agency. The US Food and Drug Administration also supports a qualified health claim that consumption of oleic acid (the main component of olive oil) may reduce the risk of coronary heart disease.

Mediterranean Diet Significantly Reduces Depression

Posted on by The Olive Oil Hunter

Reprinted from an article in Science Tech Daily, May 26, 2022

Young men with a poor diet saw a significant improvement in their symptoms of depression when they switched to a healthy Mediterranean diet, a new study shows.

Depression is a widespread mental health issue that affects roughly 300 million people globally each year. It is a substantial risk factor for suicide, the largest cause of mortality among young people. The 12-week randomized controlled trial, conducted by experts from the University of Technology Sydney, was recently published in the peer-reviewed American Journal of Clinical Nutrition.

According to lead researcher Jessica Bayes, a Ph.D. candidate at the UTS Faculty of Health, the study was the first randomized clinical trial to examine the influence of a Mediterranean diet on depressive symptoms in young males (aged 18 to 25).

“We were surprised by how willing the young men were to take on a new diet,” Bayes said. “Those assigned to the Mediterranean diet were able to significantly change their original diets, under the guidance of a nutritionist, over a short time frame.”

“It suggests that medical doctors and psychologists should consider referring depressed young men to a nutritionist or dietitian as an important component of treating clinical depression,” she said.

The link between food and mood

The research contributes to the emerging subject of nutritional psychiatry, which seeks to investigate the impact of particular nutrients, foods, and dietary patterns on mental health. The study’s diet was rich in colorful vegetables, legumes, and whole grains, as well as oily fish, olive oil, and raw, unsalted nuts.

“The primary focus was on increasing diet quality with fresh whole foods while reducing the intake of ‘fast’ foods, sugar, and processed red meat,” Bayes said. “There are lots of reasons why scientifically we think food affects mood. For example, around 90 percent of serotonin, a chemical that helps us feel happy, is made in our gut by our gut microbes. There is emerging evidence that these microbes can communicate to the brain via the vagus nerve, in what is called the gut-brain axis.”

“To have beneficial microbes, we need to feed them fiber, which is found in legumes, fruits, and vegetables,” she said.

Roughly 30 percent of depressed patients fail to adequately respond to standard treatments for major depressive disorder such as cognitive behavioral therapy and antidepressant medications. “Nearly all our participants stayed with the program, and many were keen to continue the diet once the study ended, which shows how effective, tolerable, and worthwhile they found the intervention,” Bayes concluded.

Reference: Bayes J, Schloss J, Sibbritt D. The effect of a Mediterranean diet on the symptoms of depression in young males (the AMMEND study): a randomized controlled trial. Am J Clin Nutr. 2022;116(2): 572-580. doi:10.1093/ajcn/nqac106