Fresh-Pressed Olive Oil Club

Olive Oil Hunter News #170

Horiatiki Salad Recipe and The MIND Diet for Brain Health: More Benefits of Olive Oil

I’m a huge fan of both Greek and Middle Eastern salads, the ingredients of which are not only delicious but also mainstays of the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, a way of eating designed for brain health. It’s an offshoot of the super-healthy Mediterranean diet and the DASH (Dietary Approaches to Stop Hypertension) diet. Why the distinction? Because the latest research on the MIND diet shows it can slow aging as well as reduce dementia risk. Add this to the list of the benefits of olive oil—it’s one of the super foods that MIND suggests including every day.

Horiatiki: The Sequel!

  • Triple Berry Ice Cream Triple Berry Ice Cream

    Luscious and refreshing with chunks of frosty berries, this fruit- and EVOO-infused dessert is an ice cream lover’s dream. Ice cream isn’t complicated to make with a machine to churn it for you. If you have a KitchenAid stand mixer, buying its ice cream attachment is a cost-effective option; the bowl, as with other brands that don’t have a built-it compressor, needs 24 hours in the freezer before use.

    Ingredients

    • 2 cups heavy cream
    • 1 cup half-and-half
    • 3/4 cup sugar, divided use
    • 1/4 teaspoon coarse salt
    • 2 teaspoons vanilla extract
    • 2 cups mixed blueberries, raspberries, and strawberries, plus more for garnish if desired 
    • 2 tablespoons extra virgin olive oil

    Directions

    Step 1

    Make the ice cream base. Heat the heavy cream and half-and-half in a saucepan over medium heat until it reaches a simmer and forms a skin on the surface. Off the heat, whisk in 1/2 cup sugar, the salt, and the vanilla, whisking until the sugar is fully incorporated. Let the base come to room temperature, then refrigerate until cold (it can be made up to 3 days in advance).

    Step 2

    Just before you’re ready to make the ice cream, hull the strawberries and cut them into 1/2-inch dice. Add them to a bowl with the rest of the berries and the remaining 1/4 cup sugar. Toss well, then use a potato masher or pestle to mash the fruit just a bit. Fold in the olive oil and set aside. 

    Step 3

    Give the ice cream base a quick whisk, pour into your ice cream maker, and turn on the machine. Once the ice cream holds its shape, add in the berries with all their juices and finish churning. You can enjoy the ice cream as a soft serve after churning or, for a firmer consistency, transfer to a freezer-safe container and place in the freezer for 2 hours or more. Before serving, garnish portions with more berries if desired.

    Yields 8 or more servings 

  • Cheesy Onion Chips/wraps Olive Oil Hunter News #270

    Cheesy Onion Wraps Recipe, Spotlight on Vidalia Onions, Storing Onions, Are You Getting Enough B12 and The Benefits of 30 Minutes of Weekly Exercise

    Sandwich wraps are handy alternatives to bread but can lack flavor. My cheesy onion wraps are so good you’ll be tempted to eat them right out of the pan (be sure to let them cool off first!). This issue of the newsletter looks at new research on the all-important vitamin B12 and why many people could be short. And for those who have a hard time fitting in exercise, I’m including details of a report that suggests 30 minutes per week rather than per day can still be helpful.

    Olive Toast

    Healthy Ingredient Spotlight: Vidalia Onions

    Healthy Ingredient Spotlight

    Vidalia Onions

    Grown in a limited area in Georgia, these onions are super sweet, thanks to their low sulfur content, which makes them less pungent and tear-inducing than other onion varieties. Their mild flavor profile means you can enjoy them raw, but they’re equally delicious cooked.

    These onions are a good source of vitamin C, B6, and folate, potassium and manganese as well as quercetin, an antioxidant known for its anti-inflammatory properties, and fiber. They’re available from April to August; look for their trademark logo as well as their flatter shape. 

    Quick Kitchen Nugget: Storing Onions

    Quick Kitchen Nugget

    Storing Onions

    Vidalias have a high moisture content, and some experts recommend wrapping each one in a paper towel and storing them in the crisper drawer of your fridge. If you’re going to be using them in a few days, you can keep them on a rack in a cool, dry cabinet. But always keep any onions far away from potatoes because the ethylene gas produced by onions will cause your spuds to spoil prematurely. 

    For Your Best Health: Are You Getting Enough B12?

    For Your Best Health 

    Are You Getting Enough B12?

    Vitamin B12 is essential for helping your body make DNA, red blood cells, and healthy nerve tissue. While there are guidelines for daily intake, that amount may not actually be enough to protect the brain in later years. Researchers at the University of California San Francisco (UCSF) found that older adults with “normal” but lower levels of active B12 showed signs of slower thinking, delayed visual processing, and more damage to the brain’s white matter — the communication highways that help different brain regions work together. The findings raise the possibility that some people may be told their B12 status is fine while their brains are already showing early signs of strain.

    For the study, published in Annals of Neurology, researchers enrolled 231 healthy older adults through the Brain Aging Network for Cognitive Health (BrANCH) study at UCSF. The participants had an average age of 71, and none had dementia or mild cognitive impairment. Their average blood B12 level was 414.8 pmol/L, far above the US minimum cutoff of 148 pmol/L. Instead of relying only on total B12, the researchers focused on the biologically active form of the vitamin, which may better reflect how much B12 the body can actually use. The study focused on older adults, a group that may be especially sensitive to lower B12 because absorption can become less efficient with age. Some medications, digestive conditions, and diets low in animal-based foods can also increase the risk of low B12.

    After adjusting for age, sex, education, and cardiovascular risk factors, the team found that participants with lower active B12 had slower processing speed on cognitive tests. The effect was stronger with older age. They also had delayed responses to visual stimuli, pointing to slower visual processing and reduced brain signaling efficiency. 

    MRI scans added another warning sign. Participants with lower active B12 had a higher volume of white matter lesions, which are areas of brain injury that have been linked to cognitive decline, dementia, and stroke risk. Even in this relatively healthy group, lower levels of active B12 were linked to slower thinking, slower visual processing, and more visible injury in the brain’s white matter. 

    The work was led by senior author Ari J. Green, MD, of the UCSF Departments of Neurology and Ophthalmology and the Weill Institute for Neurosciences. Dr. Green and his colleagues said the results call attention to a possible weakness in current B12 guidelines. The minimum threshold used to define deficiency may not capture early functional changes in the nervous system.

    “Previous studies that defined healthy amounts of B12 may have missed subtle functional manifestations of high or low levels that can affect people without causing overt symptoms,” said Dr. Green, noting that clear deficiencies of the vitamin are commonly associated with a type of anemia. “Revisiting the definition of B12 deficiency to incorporate functional biomarkers could lead to earlier intervention and prevention of cognitive decline.” 

    The findings suggest that low but technically normal B12 could have broader effects than previously recognized. These levels could “impact cognition to a greater extent than what we previously thought and may affect a much larger proportion of the population than we realize,” said co-first author Alexandra Beaudry-Richard, MSc, who is currently completing her doctorate in research and medicine at the UCSF Department of Neurology and the Department of Microbiology and Immunology at the University of Ottawa.

    “In addition to redefining B12 deficiency, clinicians should consider supplementation in older patients with neurological symptoms even if their levels are within normal limits,” she said. “Ultimately, we need to invest in more research about the underlying biology of B12 insufficiency, since it may be a preventable cause of cognitive decline.”

    The UCSF findings do not prove that lower active B12 directly causes cognitive decline, and they do not mean every older adult should begin taking supplements without medical guidance. They do, however, suggest that the current definition of B12 deficiency may be too blunt for brain health.

    Fitness Flash Icon: The Benefits of 30 Minutes of Weekly Exercise 

    Fitness Flash

    The Benefits of 30 Minutes of Weekly Exercise 

    Current health recommendations suggest exercising for at least 2.5 hours each week, with 5 hours considered even better. For many people, that target can seem overwhelming. Here’s music to their ears: According to researchers at the Norwegian University of Science and Technology (NTNU), you may not need hours at the gym to boost your health after all. Studies from the past two decades suggest that just 30 minutes of high-intensity exercise per week can improve health. That works out to roughly 4.3 minutes per day or about 10 minutes every other day. 

    The important part is intensity. The activity needs to be strenuous enough to leave you noticeably out of breath. If you use a heart rate monitor, researchers say your heart rate should reach about 85 percent of your maximum. However, special equipment is not necessary. A simple way to judge intensity is by how difficult it is to talk. You should still be able to speak in short sentences, but you should not be able to sing or carry on a continuous conversation comfortably.

    “The biggest reported challenge regarding exercise is lack of time. But with intense, short workouts, this is no longer a valid excuse,” said Ulrik Wisløff, a professor at NTNU and head of CERG, a research group that studies the health effects of exercise. Researchers say even a small amount of high-intensity activity can improve cardiovascular fitness, which plays a major role in long-term health. “Cardiovascular fitness is the best indicator of current and future health. Good cardio fitness reduces the risk of over 30 lifestyle diseases as well as premature death by 40 to 50 percent,” explained Wisløff.

    CERG first documented these effects in a 2006 study that analyzed health information from 60,000 people. Since then, additional large studies from Norway and other countries have reported similar findings.

    Intense home exercise for heart health

    Rather than doing one intense 30-minute workout each week, it’s best to spread out the sessions, said Wisløff. Blood pressure and blood sugar control improve for 24 to 48 hours after a workout that pushes you hard enough to become breathless for several minutes. Because of these short-term benefits, divide exercise across two to four days per week whenever possible.

    That does not necessarily mean sprinting at full speed or using the highest resistance setting on an exercise bike. “Your own personal fitness level determines what gives you a high heart rate,” Wisløff said. “If you are not very fit, simply taking a brisk walk may be enough. Having said that, you need to walk fast enough that you get quite out of breath. You can then increase the intensity as your fitness improves. Short intervals are effective. For example, this could be bursts of 45 seconds with 15-second breaks. Or like in Tabata workouts, with intense 20-second intervals interspersed with 10-second breaks. Otherwise, 4×4 intervals are recognized as highly effective for increasing oxygen uptake.”

    “Fitness is something you have to maintain. Cardio fitness and strength decline quickly when not maintained, especially as you get older,” said Atefe R. Tari, PhD, a researcher and head of CERG’s initiative on exercise and brain health. Strength training is also considered important, particularly for middle-aged and older adults. “We know that strength training is important, especially for middle-aged and older adults. There is limited research on how strength training affects lifespan, but a HUNT study exploring this is due to be published soon,” said Wisløff. “Physical health and brain health are closely linked, and cardio fitness is key here as well. Exercise leads to the formation of new brain cells,” added Dr. Tari.

    Wisløff and Tari are now encouraging Norwegian health authorities to revise the country’s official exercise recommendations, arguing that exercise intensity should receive greater emphasis.

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  • Cheesy Onion Chips/wraps Cheesy Onion Wraps

    Looking for a grain-free wrap to replace pitas or tortillas? This sheet pan hack is so flavorful you may never go back! It gets its goodness from sweet onions and salty Parmigiano-Reggiano. You can also cut the cooked sheet into shapes to top burgers or enjoy on their own as snacks. Bookmark this one for next autumn: Cut into rounds to make delicious toppers for French onion soup (use any sweet onion when Vidalias are out of season).

    Ingredients

    • 8 ounces Parmigiano-Reggiano
    • 1 large Vidalia onion, about 16 ounces
    • Extra virgin olive oil
    • 1/2 teaspoon salt
    • 2 teaspoons garlic powder

    Directions

    Step 1

    Preheat your oven to 400°F. Line a rimmed sheet pan with heat-resistant parchment paper. Shred the cheese and the onion using the medium shredding blade of a food processor or the large hole side of a hand grater (there’s no need to rinse the grater between the cheese and the onion). Toss the cheese and onions well, then spread out in an even layer on the prepared pan. Drizzle generously with olive oil and sprinkle with the salt and garlic powder. Bake for 20 minutes or until the onions and cheese have browned. It will be bubbly when you take it out of the oven.

    Step 2

    Allow to cool to room temperature to crisp up, about 20 minutes. Then cut into thirds for sandwich wraps and fill as desired.

    Makes 3 wraps

  • Olive toast Olive Oil Hunter News #269

    Olive Toast Recipe, Spotlight on Castelvetrano Olives, Storing Bread, Weight Loss Tweaks and Walking and Weight Loss

    Move over, avocado. There’s a new toasty trend taking shape and it starts with olives. The best part? You can get creative with toppings—yes, even add a layer of avo if you like. I’m also sharing new findings about effective weight loss and how to keep it off.

    Olive Toast

    Healthy Ingredient Spotlight: Castelvetrano Olives

    Healthy Ingredient Spotlight

    Castelvetrano Olives

    Castelvetranos olives

    If you’re someone who adores fresh-pressed olive oil yet shies away from olives, Castelvetranos are for you. Known as Nocellara del Belice, this varietal from the Valle del Belice region of Sicily is known for its buttery flavor and smooth skin and is a great source of healthy monounsaturated fats. 

    Quick Kitchen Nugget: Storing Bread

    Quick Kitchen Nugget

    Storing Bread

    Grandma’s bread box was a great way to keep a loaf fresh. The modern-day innovation is a linen bread bag, available for crusty round loaves or baguettes. The fabric helps keep the crust firm without drying out the insides…but only for 2 or 3 days. If you need longer storage, slice the loaf and freeze.   

    For Your Best Health: Weight Loss Tweaks

    For Your Best Health 

    Weight Loss Tweaks

    A study led by the Barcelona Institute for Global Health (ISGlobal) and published in the International Journal of Behavioral Nutrition and Physical Activity found that two habits are linked to a lower body mass index (BMI) over time: extending the overnight fasting period and eating breakfast early. Scientists think this is because eating earlier aligns better with the body’s internal clock. On the other hand, skipping breakfast as part of intermittent fasting didn’t offer the same advantage and may even be tied to unhealthy habits. 

    The findings are based on data from more than 7,000 adults between the ages of 40 and 65 who are part of the GCAT | Genomes for Life cohort, led by the Germans Trias i Pujol Research Institute (IGTP) in Barcelona. In 2018, participants provided details about their height, weight, meal timing, lifestyle habits, and socioeconomic background through questionnaires. Five years later, in 2023, more than 3,000 of these individuals returned for follow-up assessments. Researchers recorded updated measurements and collected new survey data, allowing them to track changes and identify patterns over time.

    “Our results, in line with other recent studies, suggest that extending the overnight fast could help maintain a healthy weight if accompanied by an early dinner and an early breakfast. We think this may be because eating earlier in the day is more in line with circadian rhythms and allows for better calorie burning and appetite regulation, which can help maintain a healthy weight. However, it is too soon to draw definitive conclusions, so recommendations will have to wait for more robust evidence,” explained Luciana Pons-Muzzo, MPH, researcher at ISGlobal at the time of the study and currently at IESE Business School.

    When researchers compared results by gender, they found notable differences. Women generally had lower BMI, followed the Mediterranean diet more closely, and were less likely to drink alcohol. At the same time, they reported poorer mental health and were more often responsible for household or family supervision.

    Using a method called cluster analysis, the team grouped participants with similar characteristics. One small group of men stood out. These individuals typically ate their first meal after 2 pm and fasted for about 17 hours. Compared to others, they were more likely to smoke and drink alcohol, less physically active, and less likely to follow the Mediterranean diet. They also tended to have lower levels of education and higher rates of unemployment. Researchers did not observe a similar pattern among women.

    “There are different ways of practicing what is known as intermittent fasting and our study relates to one of them, which is overnight fasting. What we observed in a subgroup of men who do intermittent fasting by skipping breakfast is that this practice has no effect on body weight. Other intervention studies in participants with obesity have shown that this tactic is no more effective than reducing calorie intake for reducing body weight in the long term,” said Camille Lassale, PhD, ISGlobal researcher and senior co-author of the study.

    “Our research is part of an emerging field of research known as ‘chrononutrition’, which focuses not only on analyzing what we eat, but also the times of day and the number of times we eat,” says Anna Palomar-Cros, PhD, researcher at ISGlobal at the time of the study and currently at IDIAP Jordi Gol. “At the basis of this research is the knowledge that unusual food intake patterns can conflict with the circadian system, the set of internal clocks that regulate the cycles of night and day and the physiological processes that must accompany them.” 

    This study builds on earlier ISGlobal research in chrononutrition, which found that eating dinner and breakfast earlier in the day is associated with a lower risk of cardiovascular disease and type 2 diabetes, reinforcing the idea that meal timing plays a meaningful role in long-term health.

    Fitness Flash Icon: Walking and Weight Loss

    Fitness Flash

    Walking and Weight Loss

    Many weight loss programs encourage people to walk more each day, but there has been limited evidence showing whether increasing daily steps actually helps people lose weight while dieting. It’s also unclear whether walking more can help people maintain weight loss over time and, if so, what step count may be most effective.

    “The most important—and greatest—challenge when treating obesity is preventing weight regain,” explained Professor Marwan El Ghoch, MD, of the Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. “Around 80% of people with overweight or obesity who initially lose weight tend to put some or all of it back on again within three to five years. The identification of a strategy that would solve this problem and help people maintain their new weight would be of huge clinical value.”

    Woman walking dog for weight loss

    To find such a strategy, Dr. El Ghoch and colleagues from Italy and Lebanon carried out a systematic review and meta-analysis of previous studies focused on walking and weight management and presented their soon-to-be-published analysis at this year’s European Congress on Obesity in Istanbul, Turkey.

    The researchers reviewed 18 randomized controlled trials. Of those, 14 studies involving 3,758 adults were included in the final meta-analysis. Participants had an average age of 53 years and an average BMI of 31 kg/m2. The studies included people from several countries, including the UK, US, Australia, and Japan. The trials compared 1,987 participants enrolled in lifestyle modification (LSM) programs with 1,771 people in control groups who were either dieting without additional support or receiving no treatment.

    The lifestyle modification programs combined dietary guidance with recommendations to walk more and track daily steps. These programs included an initial weight loss phase followed by a maintenance phase designed to help participants keep the weight off long term. Researchers measured participants’ daily step counts at the beginning of the studies, after the weight loss phase (average duration of 7.9 months), and after the maintenance phase (average duration of 10.3 months). At the start of the trials, both groups had similar activity levels. Participants in the LSM group averaged 7,280 steps per day, while those in the control group averaged 7,180 steps daily.

    The control group did not significantly increase daily walking and did not experience weight loss during the studies. Participants in the LSM programs, however, increased their daily step count to an average of 8,454 steps by the end of the weight loss phase. During that time, they lost an average of 4.39% of their body weight, equal to roughly 4 kg.

    Participants largely maintained their higher activity levels throughout the maintenance phase, averaging 8,241 steps per day by the end of the studies. They also kept off most of the weight they had lost, with an average long-term weight loss of 3.28%, or about 3 kg. Further analysis revealed a clear connection between higher daily step counts and reduced weight regain. Researchers found that people who increased their steps during the weight loss phase and continued that level of activity afterward were more successful at maintaining their weight loss. 

    Interestingly, walking more was not linked to greater weight loss during the initial dieting phase. Researchers believe this may be because factors such as calorie reduction have a stronger effect on short-term weight loss.

    Dr. El Ghoch said the findings show that lifestyle modification programs can support meaningful long-term weight loss. “Participants should be always encouraged to increase their step count to approximately 8,500 a day during the weight loss phase and sustain this level of physical activity during the maintenance phase to help prevent them from regaining weight,” he said. “Increasing the number of steps walked to 8,500 each day is a simple and affordable strategy to prevent weight regain.”

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  • Olive toast Olive Toast

    This makes a satisfying lunch and a great appetizer for your next get-together. I love the tangy, fruity taste of sumac, a spice that’s finally getting the attention it deserves. If you’ve got the grill on, drizzle olive oil on the bread and toast over the coals. 

    Ingredients

    • 2 tablespoons extra virgin olive oil, plus more for drizzling
    • 1 teaspoon lemon zest
    • 2 tablespoons fresh lemon juice  
    • 1 medium garlic clove, grated
    • 1/2 teaspoon sumac, such as Wild Sumac
    • 1/4 teaspoon coarse sea salt
    • 1/4 teaspoon freshly ground black peppercorns like Vine-Ripened Black Peppercorns
    • 1/8 teaspoon peperoncino (Italian crushed red pepper flakes)
    • 4 ounces each pitted Castelvetrano and Kalamata olives
    • 2 tablespoons chopped fresh flat-leaf parsley
    • 8 baguette or crusty whole-grain bread slices
    • 8 ounces goat cheese at room temperature
    • 1/4 cup chopped walnuts

    Directions

    Step 1

    In a medium bowl, whisk together the olive oil, lemon zest and juice, garlic, sumac, salt, pepper, and peperoncino. Coarsely chop the olives and add to the bowl along with the parsley; let marinate for 30 minutes.

    Step 2

    When ready to assemble, toast the bread. Spread each slice with equal amounts of goat cheese, then top with the walnuts and the olive mixture. Drizzle with olive oil and serve.

    Yields 4 lunch or 8 appetizer servings

  • Marinated Mozzarella Pearls Olive Oil Hunter News #268

    Marinated Mozzarella Pearls Recipe, Spotlight on Mozzarella, Storing Jars, The Fat Conundrum, and The Smarter Mediterranean Diet

    It’s not quite summer and I’m already looking for recipes that don’t involve turning on the oven! This mozzarella dish fits the bill. It couldn’t be more flavorful…or simpler. The cheese is the perfect foil for fresh-pressed olive oil—I know you’ll be serving it from now through autumn! One of the two new studies I’m sharing reveals that excess weight poses different threats for women and men, while the other presents a possible solution for everyone: an approach called the “smarter” Mediterranean diet. Read on for the details.

    Marinated Mozzarella Pearls

    Healthy Ingredient Spotlight: Fresh Mozzarella 

    Healthy Ingredient Spotlight

    Fresh Mozzarella 

    Fresh mozzarella and tomatoes

    Handcrafted fresh mozzarella, now available in many food markets, is a versatile cheese, ready to be enjoyed cold or melted in hot dishes. True Italian mozzarella is mozzarella di bufala, or mozzarella made from milk of the Italian Mediterranean buffalo. In the US, it is almost always made from cow’s milk, though a handful of artisanal makers are raising buffalo to produce more authentic varieties and some Italian makers export the real thing.

    Debunking cheese’s negative health rap, research published in the journal Advances in Nutrition found moderate evidence suggesting that eating cheese doesn’t increase the risk of cardiovascular diseases and may even offer some protection from these ills. Fresh mozzarella, in particular, is considered one of the healthier cheeses, due to its low fat and sodium content along with 7 grams of protein and over 200 mg of calcium per ounce.

    Quick Kitchen Nugget: Storing Jars

    Quick Kitchen Nugget

    Storing Jars

    With the move away from plastics, there are many glass options for storing food. Round clip top jars made by companies including Kilner and Weck are cylindrical containers with a hinged metal clamp and replaceable rubber seal. Great for storing dry staples like flour, grains, pasta, even teas, they’re also perfect for marinating and pickling vegetables. Mason jars go one step further—thanks to their tempered glass, they can withstand the heat of boiling water, making them ideal for canning. To meet kitchen needs, consider a range of sizes: half-pint (1 cup), pint (2 cups), quart (4 cups), and half-gallon (8 cups).

    For Your Best Health: The Fat Conundrum

    For Your Best Health 

    The Fat Conundrum

    New findings presented by a research team from Dokuz Eylul University in Izmir, Turkey at this year’s European Congress on Obesity (ECO) highlight clear differences in how obesity affects men and women. 

    “Our findings reveal intriguing differences in the way men and women respond to obesity,” said lead author Dr. Zeynep Pekel. “They show just how important gender-specific research is. Not only are sex differences a powerful player in the pathology and course of obesity, but our results indicate that such differences could be a stepping stone toward finding targeted, sex-based therapies to help in the management of people living with obesity.”

    Their findings showed that men with obesity are more likely to accumulate abdominal (visceral) fat. This type of fat surrounds internal organs and is strongly linked to serious heart and metabolic conditions. They had a slightly higher body mass index (BMI) than women (37.5 vs 36.0 kg/m²), but their waist circumference was much larger (120 vs 108 cm), and their systolic blood pressure was also higher (128 vs 122 mmHg), two factors linked to increased risk of cardiovascular disease and diabetes. The men also had significantly higher levels of liver enzymes (ALT and GGT), triglycerides, and creatinine. These findings point to a greater likelihood of liver-related and metabolic complications.

    Women with obesity, on the other hand, had higher total cholesterol (215 vs 203 mg/dL) and LDL or “bad” cholesterol (130 vs 123 mg/dL). They typically store more fat beneath the skin and showed higher levels of inflammatory markers, including erythrocyte sedimentation rate, C-reactive protein, and platelet count, raising the risk of heart disease and type 2 diabetes. 

    “It’s still early days and these findings need to be confirmed in other patient groups, but they offer important insight into how obesity may affect men and women differently,” said Dr. Pekel. “These differences are likely influenced by biological factors such as hormones, immune responses, and fat distribution. Our next steps are to validate these findings in larger populations, better understand the biological processes behind these differences, and explore how these patterns relate to clinical risk.”

    Fitness Flash Icon: The Smarter Mediterranean Diet 

    Fitness Flash

    The Smarter Mediterranean Diet 

    Mediterranean foods

    The Mediterranean diet is already famous for its heart and metabolic benefits. Now a large European study called the PREDIMED-Plus Trial revealed that a lower-calorie Mediterranean diet may work even better against type 2 diabetes when paired with three realistic upgrades: eating fewer calories, moving more, and getting professional support for weight loss.

    The trial found that this more structured version of Mediterranean living reduced the risk of developing type 2 diabetes by 31% over six years. Participants also lost more weight (3.3 kg), reduced abdominal fat more effectively, and reduced waist circumference by 3.6 cm, compared to those following a standard Mediterranean diet alone. 

    In real world terms, the researchers estimated that the program prevented about three cases of type 2 diabetes for every 100 participants. For a condition affecting hundreds of millions of people globally, that kind of prevention could add up quickly if applied broadly among people at elevated risk.

    “Diabetes is the first solid clinical outcome for which we have shown — using the strongest available evidence — that the Mediterranean diet with calorie reduction, physical activity, and weight loss is a highly effective preventive tool,” said Miguel Ángel Martínez-González, Professor of Preventive Medicine and Public Health at the University of Navarra, Adjunct Professor of Nutrition at Harvard University, and one of the principal investigators of the project. “Applied at scale in at-risk populations, these modest and sustained lifestyle changes could prevent thousands of new diagnoses every year. We hope soon to show similar evidence for other major public health challenges.”

    “The Mediterranean diet acts synergistically to improve insulin sensitivity and reduce inflammation. With PREDIMED-Plus, we demonstrate that combining calorie control and physical activity enhances these benefits,” explained Miguel Ruiz-Canela, Professor and Chair of Preventive Medicine and Public Health Department at the University of Navarra’s School of Medicine and first author of the study. “It is a tasty, sustainable, and culturally accepted approach that offers a practical and effective way to prevent type 2 diabetes — a global disease that is, to a large extent, avoidable.”

    The project is the largest nutrition trial conducted in Europe and involved the University of Navarra along with more than 200 researchers from 22 other Spanish universities, as well as hospitals and research centers. The work was carried out in more than 100 primary care centers within Spain’s National Health System.

    Since the PREDIMED-Plus diabetes findings were prepared, related research has continued to strengthen the broader picture. A PREDIMED-Plus body composition analysis published in JAMA Network Open found that the energy-reduced Mediterranean diet plus physical activity helped reduce total and visceral fat while slowing age-related loss of lean mass in older adults with overweight or obesity and metabolic syndrome. That matters because visceral fat and declining muscle are closely tied to cardiometabolic risk.

    More recent PREDIMED-Plus work has also explored how sedentary time may affect cardiovascular health. A 2026 study in BMC Cardiovascular Disorders reported that replacing sedentary time with physical activity was associated with favorable five-year changes in high-sensitivity troponin T, a blood marker related to heart stress, although the pattern was not consistent across all atrial fibrillation–related biomarkers.

    A 2026 analysis from the original PREDIMED trial also highlighted the possible importance of food quality within the diet. Participants with higher cumulative intake of extra virgin olive oil had a lower risk of a broad cardiovascular outcome, while common olive oil showed weaker associations. The finding supports a practical message for readers: the Mediterranean diet is not only about eating less or eating more plants. The type and quality of fats may matter too.

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  • Marinated Mozzarella Pearls Marinated Mozzarella Pearls

    Add zest to mozzarella with this flavorful marinade. Pearls are cheese balls about the size of cherry tomatoes. Serve them as a finger food or pair with tomatoes for a first course. 

    Ingredients

    • 1 medium lemon
    • 1 garlic clove
    • 1/4 cup finely chopped mix of fresh parsley and basil leaves
    • 1/4 teaspoon crushed red pepper flakes, or more to taste
    • 1/2 cup extra virgin olive oil
    • 1/2 teaspoon coarse sea salt 
    • 16 ounces mozzarella pearls

    Directions

    Step 1

    Use a Microplane set over a medium bowl to zest the lemon (reserve the rest of the lemon for another recipe) and grate the garlic. Add the herbs, red pepper, olive oil, and salt if using and whisk well.

    Step 2

    Place the mozzarella into a half-pint lidded jar. Drizzle the olive oil mixture over the pearls and let marinate on the counter for 30 minutes. If not eating right away, cover and refrigerate (bring to room temperature before serving). 

    Serves 8

  • Double strawberry mousse Olive Oil Hunter News #267

    Double Strawberry Mousse Recipe, Spotlight on Strawberries, Buying and Storing Strawberries, The Impact of Carbs and Lowering Your Disease Risk

    As farmers’ markets pop up around the country, look for fresh strawberries ripe for turning into luscious desserts. This mousse is sinfully rich, yet so easy to whip up. Whole foods are crucial to a healthy diet, and the first study I’m sharing shows what happens when we eat too many refined carbs. The second sheds new light on the importance of exercise intensity.

    Double Strawberry Mousse

    Healthy Ingredient Spotlight: Strawberries

    Healthy Ingredient Spotlight

    Strawberries

    Strawberries are packed with essential vitamins, minerals, fiber, and phytochemicals, including anthocyanins, which give them their vivid hue, and other antioxidants to protect against oxidative stress. A study published in the journal Nutrition, Metabolism and Cardiovascular Diseases found that eating about 2 cups of strawberries a day improves heart health and cognition in older adults. 

    There is one caveat. According to the Environmental Working Group, strawberries have high levels of pesticides including “forever chemicals” (PFAS) and fungicides—they’re often ranked at the top of the Group’s “Dirty Dozen” list of most affected fruits and vegetables. Because of this, buy organic whenever you can to reduce your exposure to substances linked to cancer, hormone disruption, and brain toxicity. 

    fresh strawberries on the vine
    Quick Kitchen Nugget: Buying and Storing Strawberries 

    Quick Kitchen Nugget

    Buying and Storing Strawberries 

    Look for bright red strawberries, with bright green caps, and free of moldy spots. If you’re buying berries packed in plastic boxes, be sure to turn them over and check the underside. At home, refrigerate your berries if not using right away, but don’t wash them ahead of time, which could increase the risk for mold. Store packaged berries upside down — this puts the ventilation slots on top, allowing better air circulation. 

    For Your Best Health: The Impact of Carbs

    For Your Best Health 

    The Impact of Carbs

    Bread has long been a dietary cornerstone, sustaining societies for generations. It is deeply woven into everyday life. Carbohydrates such as bread, rice, and noodles are consumed daily around the world, yet their role in obesity and metabolism has not been explored thoroughly. With obesity rates continuing to climb, researchers are beginning to question whether this reliance on staple carbohydrates still makes sense in modern diets. While many people believe that “bread makes you gain weight” or that “carbohydrates should be limited,” it has been unclear whether the issue lies in the foods themselves or in how people choose and consume them.

    To better understand these questions, a research team led by Professor Shigenobu Matsumura at Osaka’s Graduate School of Human Life and Ecology in Japan studied how carbohydrates influence eating behavior and metabolism in mice. The researchers examined whether mice preferred foods like wheat, bread, and rice over standard chow, and how these choices affected body weight and energy use. The animals were divided into several feeding groups, including Chow, Chow + Bread, Chow + Wheat flour, Chow + Rice flour, High-fat diet (HFD) + Chow, and HFD + Wheat flour. The team tracked changes in body weight, energy expenditure, blood metabolites, and liver gene expression.

    The findings showed that mice strongly favored carbohydrate-rich foods and stopped eating their standard chow altogether. Even though their total calorie intake did not increase significantly, both body weight and fat mass went up. Mice that consumed rice flour gained weight in a similar way to those that ate wheat flour. In contrast, mice given a High-fat diet (HFD) + Wheat flour gained less weight than those on a High-fat diet (HFD) + Chow. “These findings suggest that weight gain may not be due to wheat-specific effects, but rather to a strong preference for carbohydrates and the associated metabolic changes,” said Professor Matsumura.

    Further analysis revealed higher levels of fatty acids in the blood and lower levels of essential amino acids. In the liver, fat accumulation increased, along with the activity of genes linked to fatty acid production and lipid transport. When wheat flour was removed from the diet, both body weight and metabolic abnormalities improved quickly. This suggests that moving away from a wheat-heavy diet and toward a more balanced one may help regulate body weight more effectively.

    “Going forward, we plan to shift our research focus to humans to verify the extent to which the metabolic changes identified in this study apply to actual dietary habits,” said Professor Matsumura. “We also intend to investigate how factors such as whole grains, unrefined grains, and foods rich in dietary fiber, as well as their combinations with proteins and fats, food processing methods, and timing of consumption, affect metabolic responses to carbohydrate intake. In the future, we hope this will serve as a scientific foundation for achieving a balance between ‘taste’ and ‘health’ in the fields of nutritional guidance, food education, and food development.”

    Fitness Flash Icon: Lowering Your Disease Risk

    Fitness Flash

    Lowering Your Disease Risk

    Just a few minutes of getting out of breath each day could significantly cut your risk of major diseases including heart disease, dementia, and diabetes. A large study of nearly 100,000 people published in the European Heart Journal found that it’s not just how much you move, but how intensely you move that matters. Short bursts of vigorous activity—like rushing for a bus or climbing stairs quickly—were linked to striking reductions in disease risk, especially for inflammatory conditions like arthritis, serious cardiovascular problems such as heart attack and stroke, and dementia.

    To explore this connection, researchers compared participants’ overall physical activity levels with how much of that activity was vigorous, then tracked their risk of developing eight major diseases over time. The study was led by an international team that included Professor Minxue Shen from the Xiangya School of Public Health at Central South University in Hunan, China. “We know that physical activity reduces the risk of chronic disease and premature death, and there is growing evidence that vigorous activity provides greater health benefits per minute than moderate activity,” he said. “But questions remain about the importance of intense activity versus total physical activity. For example, if two people do the same total amount of activity, does the person who exercises more vigorously gain greater health benefits? And if someone has limited time, should they focus on exercising harder rather than longer?”

    Participants, all part of the UK Biobank study, wore wrist-based accelerometers for one week. These devices captured detailed movement patterns, including short bursts of vigorous activity that people might not remember or report. Researchers used this data to calculate both total activity and the share that was intense enough to cause breathlessness.

    The team then compared these measurements with participants’ likelihood of dying or developing eight serious conditions over the next seven years: major cardiovascular disease, irregular heartbeat, type 2 diabetes, immune-mediated inflammatory diseases, liver disease, chronic respiratory diseases, chronic kidney disease, and dementia.

    The results showed that people who devoted a larger portion of their activity to vigorous movement had much lower risks across all conditions studied. Compared with those who did no vigorous activity, individuals with the highest levels saw a 63% lower risk of dementia, a 60% lower risk of type 2 diabetes, and a 46% lower risk of death. These benefits were observed even when the total time spent on vigorous activity was relatively small.

    Couple working out and sweating

    The researchers also found that intensity played a larger role for certain diseases. For inflammatory conditions such as arthritis and psoriasis, intensity appeared to be the key factor in lowering risk. In contrast, for diseases like diabetes and chronic liver disease, both how long people were active and how hard they exercised were important.

    “Vigorous physical activity appears to trigger specific responses in the body that lower-intensity activity cannot fully replicate,” Professor Shen said. “During vigorous physical activity — the kind that makes you feel out of breath — your body responds in powerful ways. Your heart pumps more efficiently, your blood vessels become more flexible, and your body improves its ability to use oxygen. Vigorous activity also appears to reduce inflammation. This may help explain why we saw strong associations with inflammatory conditions such as psoriasis and arthritis. It may also stimulate chemicals in the brain that help keep brain cells healthy, which could help explain the lower risk of dementia.

    “Our findings suggest that making some of your physical activity vigorous can provide substantial health benefits. This doesn’t require going to the gym. Adding short bursts of activity that make you slightly breathless into daily life, like taking the stairs quickly, walking fast between errands, or playing actively with children, can make a real difference. Even 15 to 20 minutes per week of this kind of effort — just a few minutes a day — was linked to meaningful health benefits.

    “Current guidelines generally focus on the amount of time spent being active per week. Our findings suggest that the composition of that activity matters and matters differently depending on which diseases you’re trying to prevent. This could open the door to more personalized physical activity recommendations based on an individual’s specific health risks,” he said, adding, “Vigorous activity may not be safe for everyone, especially older adults or people with certain medical conditions. For them, any increase in movement is still beneficial, and activity should be tailored to the individual.”

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  • Double strawberry mousse Double Strawberry Mousse

    This dessert features strawberries in the mousse and in the topping. The berries are first macerated — tossed with sugar and allowed to sit — to draw out and intensify the fruit’s flavors.

    Ingredients

    • 1 1/2 pounds fresh strawberries 
    • 2 tablespoons granulated sugar
    • 1 tablespoon extra virgin olive oil
    • 1 1/2 cups heavy cream
    • Optional: 1/3 cup confectioners’ sugar 

    Directions

    Step 1

    Hull the strawberries, then dice them and place in a large glass bowl. Add the granulated sugar and toss well; set aside for 30 minutes. Drizzle on the olive oil and mix well. Reserve 1/2 cup of the berries, cover, and refrigerate. Place the rest in a food processor and run the machine until the berries are puréed. You should have about 1-1/2 cups.

    Step 2

    Place the heavy cream in the bowl of a stand mixer or a large bowl with a hand mixer. Beat on low speed, then gradually increase to high. Whip until the cream reaches medium (not stiff) peaks, then use a spatula to fold in the strawberry purée. Taste and add the confectioners’ sugar if desired. Serve right away or refrigerate the mousse in the mixing bowl for up to 4 hours — it will firm up more as it chills.

    Step 3

    To serve, spoon equal portions of the mousse into 8 goblets or bowls and garnish with equal amounts of the reserved berries.

    Serves 8

  • Grilled Halloumi Skewers Olive Oil Hunter News #266

    Halloumi Skewers Recipe, Spotlight on Bell Peppers, Safe Grill Cleaning, Extra Virgin Olive Oil for Brain Boosts and Meditation to Rewire your Brain

    Members of the Fresh-Pressed Olive Oil Club know how much of a halloumi cheese fan I am. This recipe uses the salty, firm Cypriot cheese as part of grilled skewers that will please meat eaters and non-meat eaters alike. I’m also thrilled to share two fascinating pieces of research concerning brain health: the roles of extra virgin olive oil and meditation.

    Halloumi Skewers

    Healthy Ingredient Spotlight: The Colors of Bell Peppers

    Healthy Ingredient Spotlight

    The Colors of Bell Peppers

    Bell peppers are a great source of vitamin C (two or three times as much as an orange) plus vitamins B6, K, A, and E along with minerals and antioxidants. They come in a rainbow of colors, determined by the variety and amount of time a bell pepper spends on the plant.

    Green bell peppers appear first and are the least ripe and least sweet. As they mature, they usually turn another color, such as yellow, orange, or red. Nutrient content and taste vary among bell pepper varieties. The phytonutrients lutein and zeaxanthin, important for eye health, are found in green bell peppers. Violaxanthin, a carotenoid, is found in yellow bell peppers. Capsanthin makes fully mature bell peppers red. Red bell peppers are the most nutrient-dense and also contain lycopene and beta-carotene. 

    When it comes to bell peppers, the advice is the same as with vegetables (and fruits): Eat the rainbow to get the max benefits.

    Quick Kitchen Nugget: Safe Grill Cleaning

    Quick Kitchen Nugget

    Safe Grill Cleaning

    Recently, over 13 million grill brushes from Nexgrill and Weber were recalled because their small wire bristles can break off, stick to grill grates, and lodge in food, posing serious injury risks if swallowed. The Consumer Product Safety Commission recommends people stop using these brushes immediately and contact the manufacturers for a refund or replacement. Weber, for instance, was offering a replacement nylon bristle brush. 

    How to clean your grill grates safely? A great way is to make a thick paste of baking soda and dish liquid. Smear it over the grates, then use a crumpled ball of aluminum foil to go over each groove. Thoroughly rinse and dry. To properly season the grates, finish with a light coating of olive oil dabbed on a paper towel. 

    For Your Best Health: Extra Virgin Olive Oil for Brain Boosts

    For Your Best Health 

    Extra Virgin Olive Oil for Brain Boosts

    Extra virgin olive oil, or EVOO, has long been a cornerstone of the Mediterranean diet, known for supporting heart and metabolic health. Now, new research suggests it may also help protect the brain. Scientists from the Human Nutrition Unit at the Universitat Rovira i Virgili (URV), the Pere Virgili Health Research Institute (IISPV), and CIBEROBN have found that its benefits could extend beyond the body to the mind, working through the gut microbiome to support cognitive function.

    “This is the first prospective study in humans to specifically analyze the role of olive oil in the interaction between gut microbiota and cognitive function,” explains Jiaqi Ni, PhD, first author of the article and researcher at the URV’s Department of Biochemistry and Biotechnology.

    The research followed 656 adults between the ages of 55 and 75 who were overweight or obese and had metabolic syndrome — a set of risk factors that increase the likelihood of developing cardiovascular disease. Over a two-year period, as part of the PREDIMED-Plus project, scientists tracked participants’ diets, including their intake of virgin and refined olive oil, along with detailed analyses of their gut microbiota. They also monitored changes in cognitive performance over time.

    The findings showed clear differences depending on the type of olive oil consumed. Participants who regularly used virgin olive oil experienced improvements in cognitive function and had a more diverse gut microbiota, which is widely considered a sign of better intestinal and metabolic health. In contrast, those who consumed refined olive oil tended to show a decline in microbiota diversity over time. Researchers also identified a specific group of gut bacteria, known as Adlercreutzia, that may be tied to these benefits. Its presence could serve as an indicator of the positive relationship between virgin olive oil consumption and preserved cognitive function. These results suggest that part of the oil’s brain-supporting effect may come from how it reshapes the gut microbiome.

    The difference between extra virgin and refined olive oil largely comes down to how they are produced. Extra virgin olive oil is obtained using mechanical methods, which help preserve its natural compounds. Refined olive oil, on the other hand, undergoes industrial processing to remove impurities. While this refining process improves shelf life, it also reduces beneficial components such as antioxidants, polyphenols, vitamins, and other bioactive substances. 

    Jordi Salas-Salvadó, MD, PhD, principal investigator of the study, emphasized the importance of choosing high-quality fats: “This research reinforces the idea that the quality of the fat we consume is as important as the quantity; extra virgin olive oil not only protects the heart, but can also help preserve the brain during aging.” 

    Two of the other researchers involved, URV professor Nancy Babio-Sánchez, PhD, and Stephanie Nishi, PhD, now a professor with the Toronto Metropolitan University (Canada), highlighted the broader implications of the findings as populations continue to age: “At a time when cases of cognitive decline and dementia are on the rise, our findings drive home the importance of improving diet quality, and in particular prioritizing extra virgin olive oil over other refined versions as an effective, simple, and accessible strategy for protecting brain health.”

    Fitness Flash Icon: Meditation to Rewire your Brain

    Fitness Flash

    Meditation to Rewire your Brain

    Researchers at the University of California San Diego report that a weeklong program combining meditation and other mind-body techniques can quickly produce measurable changes in both brain activity and blood biology. The study found that these practices activated natural pathways involved in brain flexibility, metabolism, immune function, and pain relief. Surprisingly, the experience mirrored psychedelic-like brain states—without any drugs involved. Published in Communications Biology, the findings offer new evidence that mental practices can influence physical health in significant ways.

    Meditation and similar approaches have been used for thousands of years to support well-being, but scientists have struggled to explain exactly how they affect the body. This new research, part of a large initiative funded by the InnerScience Research Fund, is the first to systematically measure the combined biological effects of multiple mind-body techniques delivered over a short time.

    “We’ve known for years that practices like meditation can influence health, but what’s striking is that combining multiple mind-body practices into a single retreat produced changes across so many biological systems that we could measure directly in the brain and blood,” said senior study author Hemal H. Patel, PhD, professor of anesthesiology at UC San Diego School of Medicine and research career scientist at the Veterans Affairs San Diego Healthcare System. “This isn’t about just stress relief or relaxation; this is about fundamentally changing how the brain engages with reality and quantifying these changes biologically.”

    The study followed 20 healthy adults who took part in a 7-day residential retreat led by neuroscience educator and author Joe Dispenza, DC. Participants attended lectures and completed about 33 hours of guided meditation along with group-based healing activities.

    These sessions used an “open-label placebo” approach, meaning participants were aware that some practices were presented as placebos. Even so, such interventions can still produce real effects through expectation, shared experience, and social connection.

    Before and after the retreat, researchers used functional magnetic resonance imaging (fMRI) to monitor brain activity. Blood samples were also analyzed to track changes in metabolism, immune function, and other biological markers. After the retreat, several notable changes were detected:

    • Brain network changes: Activity decreased in regions linked to internal mental chatter, suggesting more efficient brain function.
    • Enhanced neuroplasticity: Blood plasma collected after the retreat encouraged lab-grown neurons to extend and form new connections.
    • Metabolic shifts: Cells exposed to post-retreat plasma showed increased glycolytic (sugar-burning) metabolism, indicating improved metabolic flexibility.
    • Natural pain relief: Levels of endogenous opioids, the body’s natural painkillers, rose following the retreat.
    • Immune activation: Both inflammatory and anti-inflammatory signals increased, pointing to a balanced and adaptive immune response.
    • Gene and molecular signaling changes: Small RNA and gene activity shifted in ways linked to brain-related biological pathways.

    Participants also completed the Mystical Experience Questionnaire (MEQ-30), which measures feelings such as unity, transcendence, and altered awareness during meditation. Scores increased from an average of 2.37 before the retreat to 3.02 afterward. Those who reported stronger mystical experiences also showed more pronounced biological changes, including greater coordination between different brain regions. This suggests that deeper subjective experiences may be tied to measurable changes in brain function.

    The researchers found that the brain activity patterns observed after the retreat closely resembled those previously linked to psychedelic substances. “We’re seeing the same mystical experiences and neural connectivity patterns that typically require psilocybin, now achieved through meditation practice alone,” added Patel. “Seeing both central nervous system changes in brain scans and systemic changes in blood chemistry underscores that these mind-body practices are acting on a whole-body scale.”

    The findings help explain how non-drug approaches like meditation may support overall health. By boosting neuroplasticity and influencing immune activity, these practices could improve emotional regulation, stress resilience, and mental well-being. The increase in natural pain-relief chemicals also points to potential applications for managing chronic pain.

    Future studies will explore whether similar programs could help people with chronic pain, mood disorders, or immune-related conditions. The team also plans to examine how different elements of the retreat, including meditation, reconceptualization, and open-label placebo healing, contribute individually and together. Another key question is how long these biological changes last and whether repeated practice can strengthen or maintain them.

    “This study shows that our minds and bodies are deeply interconnected — what we believe, how we focus our attention, and the practices we participate in can leave measurable fingerprints on our biology,” said first author Alex Jinich-Diamant, a doctoral student in the Departments of Cognitive Science and Anesthesiology at UC San Diego. “It’s an exciting step toward understanding how conscious experience and physical health are intertwined, and how we might harness that connection to promote well-being in new ways.”

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For Your Best Health: Managing Depression: Using Scents to Unlock Memories 

For Your Best Health

The MIND Diet for Brain Health: More Benefits of Olive Oil

According to a new study from researchers at the Columbia University Mailman School of Public Health and The Robert Butler Columbia Aging Center, a very specific brain-boosting diet has been linked to reduced dementia risk and a slower pace of aging. The study, “Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study,” published in the Annals of Neurology, also explains how the diet helps slow down the processes of biological aging.

“Much attention to nutrition in dementia research focuses on the way specific nutrients affect the brain,” said Daniel Belsky, PhD, associate professor of epidemiology and a senior author of the study. “We tested the hypothesis that healthy diet protects against dementia by slowing down the body’s overall pace of biological aging.”

The researchers used data from the second generation of the Framingham Heart Study, the Offspring Cohort. Participants were 60 years of age or older and free of dementia and had available dietary, epigenetic, and follow-up data. Follow-up was done at nine examinations, approximately every 4 to 7 years, which included a physical exam, lifestyle-related questionnaires, blood sampling, and, starting in 1991, neurocognitive testing. Of 1,644 participants included in the analyses, 140 developed dementia. 

To measure the pace of aging, the researchers used an epigenetic clock called DunedinPACE developed by Dr. Belsky and colleagues at Duke University and the University of Otago in Dunedin, New Zealand. The clock measures how fast a person’s body is deteriorating as they grow older, “like a speedometer for the biological processes of aging,” explained Dr. Belsky.

“We have some strong evidence that a healthy diet can protect against dementia,” said Yian Gu, PhD, associate professor of neurological sciences at Columbia University Irving Medical Center and the other senior author of the study, “but the mechanism of this protection is not well understood.” Past research linked both diet and dementia risk to an accelerated pace of biological aging. “Testing the hypothesis that multi-system biological aging is a mechanism of underlying diet-dementia associations was the logical next step,” explained Dr. Belsky.

The research determined that higher adherence to the MIND diet slowed the pace of aging as measured by DunedinPACE and reduced risks for dementia and mortality. Furthermore, slower DunedinPACE accounted for 27% of the diet-dementia association and 57% of the diet-mortality association.

“Our findings suggest that slower pace of aging mediates part of the relationship of healthy diet with reduced dementia risk, and therefore, monitoring pace of aging may inform dementia prevention,” said first author Aline Thomas, PhD, of the Columbia Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. “However, a portion of the diet-dementia association remains unexplained, therefore we believe that continued investigation of brain-specific mechanisms in well-designed mediation studies is warranted.”

“We suggest that additional observational studies be conducted to investigate direct associations of nutrients with brain aging, and if our observations are also confirmed in more diverse populations, monitoring biological aging may indeed inform dementia prevention,” noted Dr. Belsky.

Exactly What Is the MIND Diet?

MIND is a hybrid of the Mediterranean and DASH diets, tailored to reflect key findings from nutrition and dementia research. It details serving sizes of specific foods to focus on and which to limit, primarily those high in saturated fat, which is known to negatively affect brain health. 

Foods and portions to eat every day: 1/2 to 1 cup green leafy vegetables, 1/2 cup other vegetables, 2 tablespoons extra virgin olive oil, and three 1-ounce servings of whole grains. 

Foods and portions to eat over the course of each week: 5 ounces nuts, 2-1/2 cups berries, 1-1/2 cups legumes, two 3-to-5-ounce servings of skinless poultry, and 3-to-5 ounces fish.

Foods to limit to these weekly totals: three or fewer 3-to-5-ounce servings of red and processed meats, 1 ounce whole-fat cheese, 1 fried or fast food, and 4 sweet servings. If desired, no more than 1 teaspoon of butter or stick of margarine a day.

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Olive Oil Hunter #169

Elevated Grilled Cheese Sammies Recipe, Spotlight on Arugula, Avocado and Cast Iron Skillets, and How to Manage Chronic Pain with Exercise

Comfort foods are oh so yummy but often don’t have the best health profile. My version of the classic grilled cheese packs high-nutrient foods that deliver on taste, too. One of them is avocado, a food that’s not only good for you on its own but also seems to encourage healthier eating in general, according to a study I’m sharing. You’ll also read about a healthy therapy to help forestall or ease chronic pain. 

Elevated Grilled Cheese Sammies

  • Gourmet Grilled Cheese Sandwich Elevated Grilled Cheese Sammies

    Even finicky eaters rush to the kitchen when grilled cheese sandwiches are on the menu. With a few ingredient upgrades, this lunch or dinner mainstay tastes even more delicious.

    Ingredients

    • Extra virgin olive oil, as needed
    • 2 ounces Manchego cheese, shredded
    • 1 ripe avocado, cut into thin slices
    • 1 ripe pear, cut into thin slices
    • 1 tablespoon fig jam
    • 1-2 cups arugula
    • 4 thin slices crusty whole wheat bread

    Directions

    Step 1

    Brush one side of each slice of bread with olive oil. Build the sandwiches on two of the slices, layering the ingredients equally in this order: a sprinkling of cheese, avocado slices, pear slices, fig jam, arugula, the rest of the cheese, and the top slice of bread. 

    Step 2

    If using a panini press, brush the outsides of the bread with olive oil and heat the press and grill the sandwiches as directed. If using a griddle, heat over medium heat; when hot, add two tablespoons of olive oil in two separate pools and place a sandwich over each pool. Press down on the sandwiches with a large spatula or an empty cast iron skillet (see “Quick Kitchen Nugget” below). When the bottoms have browned, flip the sandwiches and repeat.

    Makes 2 servings

Healthy Ingredient Spotlight: Amazing Arugula

Healthy Ingredient Spotlight

Amazing Arugula

Arugula, pear and manchego salad

We often talk about sensing the spiciness of arugula when doing our fresh-pressed olive oil tastings—the tender greens are full of zesty flavor. If arugula isn’t already on your shopping list, it’s time to add it. The cool weather of spring and fall is its ideal growing environment. Young, or “baby,” arugula is milder in taste—though still peppery—than more mature or late-season harvests.

Though often found in bagged lettuce mixes, arugula (Eruca vesicaria) is actually a cruciferous vegetable, part of the same family as broccoli, cabbage, and kale—and just as packed with nutrients, including antioxidants. In addition to vitamins A, C, K, and folate and the minerals calcium, iron, potassium, and magnesium, arugula has glucosinolates, natural substances that offer some protection from certain types of cancer, such as cancers of the breast, prostate, colon, and lung (glucosinolates are also responsible for that spicy bitterness). 

Arugula makes a great addition to hot and cold sandwiches, focaccia, and pizzas—just be sure to add it after your pizza is cooked, or the high temperature of the oven will burn it quickly. 

Baby arugula tends to come prerinsed, but when growing your own or buying a bunch from the greengrocer, just before eating submerge the leaves in a large bowl of cool water and agitate them to remove any dirt. Wait two minutes, then scoop out the leaves with a spoon strainer, pat dry, and enjoy. 

Quick Kitchen Nugget: Cast Iron Skillet: A Makeshift Panini Press

Quick Kitchen Nugget

Cast Iron Skillet: A Makeshift Panini Press

The value of a panini press is that it grills both sides of a sandwich at once and compacts the contents for better cheesy goodness. But you can achieve a similar effect by placing a cast-iron skillet on top of your sandwich on a griddle or grill. You’ll still have to flip the sandwich, but the skillet’s weight will compress it as it toasts on each side. If you use this method, don’t brush the top outer piece of bread with oil until you’re ready to flip it, to keep the oil from transferring to the skillet. 

For Your Best Health: An Avocado a Day…

For Your Best Health

An Avocado a Day…

A group of researchers from Wake Forest University School of Medicine, Tufts University, the David Geffen School of Medicine at the University of California Los Angeles, Loma Linda University, and Penn State University examined how the food-based intervention of eating one nutrient-dense avocado per day could impact overall diet quality. Surprisingly, only 2% of American adults eat avocados on a regular basis, even though they’re high in fiber and healthy fats, among many other nutrients. The study was published in the journal Current Developments in Nutrition  

“Previous observational research suggests avocado consumers have higher diet quality than non-consumers. So, we developed this study to determine if there is a causational link between avocado consumption and overall diet quality,” said Kristina S. Petersen, PhD, associate professor of nutritional sciences at Penn State. 

For the research, 1,008 participants were split into two groups. One group continued their usual diet and limited their avocado intake during the 26-week study, while the other group incorporated one avocado per day into their diet.

Researchers conducted phone interviews with participants before the study began and at a few points throughout to determine what their dietary intake was like in the previous 24 hours and evaluated their diets using the Healthy Eating Index to see how well they adhered to the Dietary Guidelines for Americans, which was used as a measure of overall diet quality.

“We found that the participants who had an avocado per day significantly increased their adherence to dietary guidelines,” Dr. Petersen said. “By improving people’s adherence to dietary guidelines, we can help to reduce their risk of developing chronic conditions and prolong healthy life expectancy.…In our study, we classified avocados as a vegetable and did see an increase in vegetable consumption attributed to the avocado intake, but also participants used the avocados to replace some unhealthier options…as a substitute for some foods higher in refined grains and sodium.”

Dr. Petersen has conducted similar studies investigating the impact of food-based interventions, including the relationship between pistachios and diet quality. She added that more research is needed to determine what other food-based strategies and behavioral strategies could also be used to improve adherence to dietary guidelines.

Fitness Flash: Physical Activity for Chronic Pain Protection

Fitness Flash

Physical Activity for Chronic Pain Protection

Researchers from UiT The Arctic University of Norway, the University Hospital of North Norway (UNN), and the Norwegian Institute of Public Health knew from an earlier study of  more than 10,000 adults that those who were physically active had a higher pain tolerance than those who were sedentary—and the higher the activity level, the higher the pain tolerance. They next wanted to understand how physical activity could affect the chances of experiencing chronic pain years later and whether this is related to how physical activity affects our ability to tolerate pain. So, they embarked on new research involving almost 7,000 people recruited from the large Tromsø survey, the Norwegian database that has collected data on people’s health and lifestyle over decades.

They obtained information about the participants’ exercise habits during their free time and whether they experienced pain that lasted for 3 months or more, including widespread or severe pain. 

“We found that people who were more active in their free time had a lower chance of having various types of chronic pain 7-8 years later. For example, being just a little more active, such as going from light to moderate activity, was associated with a 5% lower risk of reporting some form of chronic pain later,” said doctoral fellow Anders Årnes at UiT and UNN, one of the researchers behind the study. He adds that for severe chronic pain in several places in the body, higher activity was associated with a 16% reduced risk.

Exercise to manage chronic pain

The researchers found that the ability to tolerate pain played a role in this apparent protective effect. “This suggests that physical activity increases our ability to tolerate pain and may be one of the ways in which activity helps to reduce the risk of severe chronic pain,” said Årnes.

When it comes to exercising if you already have chronic pain, the researcher said: “Physical activity is not dangerous in the first place, but people with chronic pain can benefit greatly from having an exercise program adapted to help them balance their effort so that it is not too much or too little. Healthcare professionals experienced in treating chronic pain conditions can often help with this. A rule of thumb is that there should be no worsening that persists over an extended period, but that certain reactions in the time after training can be expected.”

The research, “Does pain tolerance mediate the effect of physical activity on chronic pain in the general population? The Tromsø Study,” was published in the journal Pain.

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Olive Oil Hunter News #168

Iced Blueberry Scones Recipe, Spotlight on Blueberries and Bench Scrapers, Managing Depression with Scents, and Resistance Training for Anxiety

May is Mental Health Awareness Month, first established in 1949 to increase our understanding of the vital role mental health plays in overall health and well-being and to celebrate recovery from mental illness. With all the stresses of daily living we face today, addressing mental health has never been as important. So, in addition to my recipe for scones, I’m including two different advances in mental health care that could impact how depression and anxiety are managed.

Iced Blueberry Scones

  • Iced Blueberry Scones Iced Blueberry Scones

    If you’ve ever had a store-bought scone, chances are it was dry and crumbly. My recipe is flaky yet still tender, thanks to the olive oil in the pastry flour dough. A light icing drizzle balances out the tartness of blueberries. 

    Ingredients

    For the Scones:

    • 2 cups pastry flour, plus more for the cookie sheet and shaping the dough
    • 1/4 cups whole wheat pastry flour 
    • 1/3 cup sugar
    • 1 tablespoon baking powder
    • 1 teaspoon coarse sea salt
    • 1/2 cup extra virgin olive oil
    • 2/3 cup half-and-half
    • 1 extra-large egg
    • 1 teaspoon vanilla 
    • 1 cup fresh blueberries, rinsed and patted dry

    For the Glaze:

    • 1 cup confectioners’ sugar
    • 1 tablespoon freshly squeezed lemon juice

    Directions

    Step 1

    Preheat your oven to 400°F. Line a cookie sheet with parchment paper and sprinkle it liberally with flour.

    Step 2

    Place the 2-1/4 cups flour (pastry and whole wheat), sugar, baking powder, and salt in a mixing bowl and whisk to combine. In a separate bowl, thoroughly whisk the olive oil, half-and-half, egg, and vanilla. Using a large spatula, fold in the blueberries and then the flour mixture. Be careful not to overmix, which can cause too much gluten development and a dense scone.

    Step 3

    Turn the dough out onto the parchment paper. Heavily flour your hands and use them to pat the dough into a 12-by-8-inch rectangle (do not use a rolling pin). If the dough is extremely wet, sprinkle on a tablespoon of additional flour. Use a bench scraper to help even out the edges, cut the dough into 12 triangles or squares, and then move the pieces as needed to leave about two inches between them.

    Step 4

    While the scones are cooling, mix the confectioner’s sugar and lemon juice, thinning if needed with 1 tablespoon of water. Use a spoon to drizzle on the icing in a crisscross pattern.

    Step 5

    Serve warm or at room temperature. Store any leftovers in the fridge.

    Yields 12 scones

Healthy Ingredient Spotlight: Frozen Blueberries

Healthy Ingredient Spotlight

Frozen Blueberries

Blueberries are more than delicious—they’re at the top of many healthiest-foods lists because of their amazing nutrients. Along with vitamins C and K and the mineral manganese, they’re rich in anthocyanins, which give them their blue-purple color and protect cells from damaging molecules called free radicals. Their soluble fiber helps lower blood sugar, manage blood pressure, and sweep out cholesterol, which, in turn, can lower the risk for heart disease. 

Spring is the start of blueberry season, but when fresh ones aren’t available, frozen ones make a great stand-in (it’s also smart to freeze fresh berries you grow or buy throughout the summer so that you’ll have them for next fall and winter). Bakers are often disappointed by the bleeding frozen berries can cause, creating streaks of purple or even green in the finished baked goods. This doesn’t affect taste, but here’s a quick hack to avoid it: Just before adding them to your batter, rinse the frozen berries well in cold water and then thoroughly pat them dry between layers of paper towels. Quickly fold them into the batter using just a few strokes. Keep in mind that you are rinsing away some of the berries’ healthful anthocyanins, so if the streaks don’t bother you, simply pat defrosted berries with paper towels before adding them to the batter to avoid adding excess moisture.

Quick Kitchen Nugget: The Value of a Bench Scraper

Quick Kitchen Nugget

The Value of a Bench Scraper

This lightweight tool, designed to help you move dough when working on a countertop or “bench,” does more than its name indicates. Press the side against your dough to even its sides—this may eliminate the need for trimming the edges. Use the edge of the scraper to cut dough into scones, biscuits, bar cookies, or crackers. Also, the flat side works like a metal spatula to transfer dough pieces to your baking sheet. Available at most housewares stores and online, a good stainless steel bench scraper runs $10-$15.

Bench Scraper
For Your Best Health: Managing Depression: Using Scents to Unlock Memories 

For Your Best Health

Managing Depression: Using Scents to Unlock Memories 

A study done by University of Pittsburgh School of Medicine researchers and University of Pittsburgh Medical Center social workers and published in JAMA Network Open has found that scents are more effective than words at calling up a memory of a specific event. Scents could even be used to help people experiencing depression get out of negative thought cycles and rewire thought patterns, aiding faster and smoother healing.

Early in her career, Kymberly Young, PhD, a neuroscience researcher who studies autobiographical memories, realized that engaging the amygdala, the part of the brain that not only controls the fight-or-flight response but also directs attention and focus to important events, helps with memory recall. 

She also knew of extensive evidence that people with depression have a hard time recalling specific autobiographical memories and that, in healthy individuals, odors trigger memories that feel vivid and real, likely because they directly engage the amygdala through nerve connections from the olfactory bulb.

“It was surprising to me that nobody thought to look at memory recall in depressed individuals using odor cues before,” said Dr. Young, senior author of the study and associate professor of psychiatry at Pitt. So, she decided to test whether engaging the amygdala could help depressed individuals access their memories more effectively. 

Rather than start with brain scanner tests, she decided to go low tech, presenting study participants with a series of opaque glass vials containing potent familiar scents including everything from oranges and ground coffee to shoe polish and even Vicks VapoRub.

After asking participants to smell a vial, Dr. Young asked them to recall a specific memory, good or bad. She was surprised to discover that memory recall was stronger in depressed individuals who received odor cues as opposed to word cues. Also, those who received odor cues were more likely to recall a memory of a specific event (for example, that they went to a coffee shop the previous Friday) than general memories (that they have been to coffee shops before). Memories spurred by odors were also a lot more vivid and felt more immersive. Even though Dr. Young did not direct participants to specifically recall positive memories, her results found that positive memories were more likely to be recalled.

Dr. Young will soon start more technologically advanced studies using a brain scanner, but she is excited about the progress already made. “If we improve memory, we can improve problem-solving, emotion regulation, and other functional problems that depressed individuals often experience,” she said.

Fitness Flash: Resistance Training for Anxiety

Fitness Flash

Resistance Training for Anxiety

Researchers Matthew P. Herring, PhD, of the University of Limerick (UL) in Ireland, and Jacob D. Meyer, PhD, of Iowa State University (ISU), recently published an article in the journal Trends in Molecular Medicine to review evidence supporting the positive effects that resistance exercise training can have on anxiety and depression.  

“There is a critical need for confirmatory, definitive trials that adequately address limitations [of existing research], but the limited evidence available to us provides initial support for the beneficial effects of resistance exercise training on these mental health outcomes, including increased insulin-like growth factor 1, cerebrovascular adaptations, and potential neural adaptations influenced by controlled breathing inherent to resistance exercise,” explained Dr. Herring, associate professor in the Physical Activity for Health Research Centre, Health Research Institute, and department of physical education and sport sciences within the faculty of education and health sciences at UL, and a fellow of the American College of Sports Medicine. 

Resistance training/exercise

“Notwithstanding the limitations of the limited number of studies to date, there is exciting evidence, particularly from our previous and ongoing research of the available studies, that suggests that resistance exercise training may be an accessible alternative therapy to improve anxiety and depression. Anxiety and depressive symptoms and disorders are prevalent and debilitating public health burdens for which successful treatment is limited,” Dr. Herring said. “A more exciting aspect is that there is substantial promise in investigating the unknown mechanisms that may underlie these benefits to move us closer to maximizing benefits and to optimizing the prescription of resistance exercise via precision medicine approaches.” 

“The current research provides a foundation for testing if resistance training can be a key behavioral treatment approach for depression and anxiety,” said Dr. Meyer, an expert on the neurobiological effects of exercise on depression and director of ISU’s Wellbeing and Exercise Laboratory, focused on understanding how exercise and sedentary activities are related to mental health and well-being. “As resistance training likely works through both shared and distinct mechanisms to achieve its positive mood effects compared to aerobic exercise, it has the potential to be used in conjunction with aerobic exercise or as a stand-alone therapy for these debilitating conditions. Our research will use the platform established by current research as a springboard to comprehensively evaluate these potential benefits of resistance exercise in clinical populations while also identifying who would be the most likely to benefit from resistance exercise.”

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Olive Oil Hunter News #167

Composed Salad with Apple Balsamic Vinaigrette Recipe, Spotlight on Salad Greens, A Monthly 5-day Modified Fast to Boost Longevity and A Surprising Advantage of Exercise 

Composed salad—only the name of this dish sounds tricky. It’s actually a simple technique to arrange ingredients in a beautiful display and let everyone pick and choose what to put on their own plate. I’ve provided suggestions, but you get to pick your culinary adventure! 

Club members know that I believe in nourishing the body with healthful foods (that’s why sourcing fresh-pressed olive oil brimming with polyphenols is so important to me!). And in turn, the body can enrich us in remarkable ways. Two studies provide astounding food for thought to prove that point. The first is a new approach to intermittent fasting, and the second shows how bookmarking learning something new with bouts of physical exercise can help you retain the new information. Enjoy these fascinating reads.

Composed Salad with Apple Balsamic Vinaigrette

  • Composed Salad Composed Salad with Apple Balsamic Vinaigrette

    Sounds complicated and even more exotic in its original French—“salade composée”—but a composed salad is nothing more than an artful way to arrange your ingredients rather than tossing them together. Salade Niçoise and Cobb salad are two that are typically presented this way, but a composed salad can be made of any ingredients you choose—and it’s a great way to showcase fresh seasonal vegetables and even fruits. The following ingredients and directions are merely guidelines—let your imagination be your guide and remember that unusual combos can be delicious. Whatever you choose should have a flavorful dressing, so I’m including the recipe for one of my favorite vinaigrettes. It uses apple balsamic vinegar, a great change from classic balsamic of Modena.

    Ingredients

    For the vinaigrette:

    • 1⁄4 cup Apple Balsamic Vinegar
    • 1⁄4 teaspoon dried basil leaves, crushed 
    • 1 small shallot, minced 
    • 1 garlic clove, minced 
    • Pinch red pepper flakes
    • 1⁄2 cup extra virgin olive oil
    • Coarse salt and freshly ground black pepper to taste

    For the platter, choose any combination:

    • Protein: pick 1 or 2, such as sliced chicken, hard-boiled egg halves, or strips of prosciutto
    • Cheese: pick 1 or 2 such as cubes of fresh mozzarella or aged Parmigiano-Reggiano, or thin rounds of goat cheese
    • Greens: pick 1 lettuce or another leafy green, like arugula or baby spinach
    • Vegetables: pick 3 or 4, raw, steamed, or grilled, such as asparagus, cherry tomatoes, and string beans
    • Fruit and nuts: pick 1 or more, such as grapes, apple or pear slices, raisins or another dried fruit, avocado, and almonds or walnuts 
    • Legumes: pick 1, such as cooked beans or chickpeas

    Directions

    Step 1

    Make the vinaigrette: In a medium mixing bowl, whisk together the vinegar, basil, shallot, garlic, and red pepper flakes. Gradually whisk in the olive oil until the dressing is emulsified. Season to taste with salt and pepper.

    Step 2

    Compose your salad: Rinse and pat dry all raw ingredients. Cut all ingredients into bite-size pieces or thin slices. Lettuces and other greens can be sliced into ribbons. Choose a large platter and place one ingredient at a time, going from left to right. 

    Step 3

    Place the vinaigrette on the side so each person can add as much or as little as they want.

    Yields 4 servings

Healthy Ingredient Spotlight: Salad Greens 

Healthy Ingredient Spotlight

Salad Greens 

I’m a fan of varying the greens in my salads rather than sticking to one type every time. This choice goes beyond taste—each green has a different nutrient profile, so mixing it up means you get a wider range of vitamins, minerals, and other phytochemicals. Here are some choices to put in your own personal rotation.

Iceberg is one of the few lettuces that comes in a very compact head; another is romaine. The leaves of the more delicate butterhead and Boston lettuces are more loosely held together. Red or green loose-leaf lettuce and escarole aren’t compact at all.  

Many greens are sold as leaves, bundled or loose, including watercress, Swiss chard, arugula, baby spinach, and dandelion greens. Some leaves, like kale, have rigid spines or stems that you might want to remove if eating raw but that soften when cooked. 

All greens are a good source of fiber and water. Romaine and spinach have the highest amounts of vitamin A and folate (a B vitamin), spinach and Swiss chard are highest in vitamin K and potassium, and kale and spinach take top honors for calcium.

Quick Kitchen Nugget: Storing Salad Greens

Quick Kitchen Nugget

Storing Salad Greens

Salad greens

It’s frustrating to buy a box or package of greens—or even a loose head—only to find that some of the leaves have turned when you go to make a salad. These quick tips can help keep them fresh.

If possible, store greens by themselves (and definitely away from any fruit) in one of the crisper drawers of your fridge with the humidity set at high. Newer, more high-tech refrigerators offer very precise climate control, sometimes through an app on your phone.  

If your greens are bagged, you can try the puffing technique: blow into the bag to puff it up (like a balloon) and then seal in the air by closing the bag with a rubber band. Another option, especially if your greens are in a plastic clamshell or tight bag, is to spread them out in single layers between sheets of paper towels (discard any leaves that have wilted), roll up the paper towels, and store the roll in a reusable container. Rinse before eating, not before storing.

For Your Best Health: A Monthly 5-day Modified Fast to Boost Longevity

For Your Best Health

A Monthly 5-day Modified Fast to Boost Longevity

We’ve shared reports of studies showing that you may be able to reduce inflammation and better ward off diseases with intermittent fasting—eating fewer than 500 calories on two days of every week or limiting eating to an 8- or 10-hour daily window. Recently, a University of Southern California Leonard Davis School of Gerontology-led study, published in the journal Nature Communications, found that one five-day monthly cycle of a diet that mimics fasting, known as a fasting-mimicking diet (FMD), can reduce signs of immune system aging, as well as insulin resistance and liver fat, resulting in a lower “biological” age—a measure of how well your cells and tissues are functioning regardless of your chronological age.

The FMD, developed by Valter Longo, PhD, the study’s senior author and professor at the USC Leonard Davis School, is high in unsaturated fats and low in overall calories, protein, and carbohydrates. It’s designed to mimic the effects of a water-only fast while still providing necessary nutrients and making it much easier for people to complete. 

“This is the first study to show that a food-based intervention that does not require chronic dietary or other lifestyle changes can make people biologically younger, based both on changes in risk factors for aging and disease and on a validated method developed by the Levine group to assess biological age,” Dr. Longo said. (The Levine group, led by Morgan Levine, PhD, designs tools just to measure biological age.) 

Previous research led by Longo indicated that brief, periodic FMD cycles are associated with a range of beneficial effects, such as promoting stem cell regeneration, easing chemotherapy side effects, and reducing the signs of dementia in mice. Dr. Longo’s lab also had previously shown that one or two cycles of the FMD for five days a month increased the health span and lifespan of mice on either a normal or a Western diet, but the effects of the FMD on aging and biological age, liver fat, and immune system aging in humans were unknown until now. In addition, the FMD cycles can lower the risk factors for cancer, diabetes, heart disease, and other age-related diseases in people.

The study analyzed the diet’s effects in two clinical trial populations, each with men and women between the ages of 18 and 70. Patients who were randomized to the fasting-mimicking diet underwent 3-4 monthly cycles, adhering to the FMD for 5 days, then ate a normal diet for 25 days. The FMD is comprised of plant-based soups, energy bars, energy drinks, chip snacks, and tea plus a supplement providing high levels of minerals, vitamins, and essential fatty acids. 

An analysis of blood samples from trial participants showed that those in the FMD group had lower diabetes risk factors, including less insulin resistance and lower HbA1c results. Magnetic resonance imaging also revealed a decrease in abdominal fat as well as fat within the liver, improvements associated with a reduced risk of metabolic syndrome. In addition, the FMD cycles appeared to increase the lymphoid-to-myeloid ratio, an indicator of a more youthful immune system. Further statistical analysis of the results showed that FMD participants had reduced their biological age by 2.5 years on average.

“This study shows for the first time evidence for biological age reduction from two different clinical trials, accompanied by evidence of rejuvenation of metabolic and immune function,” Dr. Longo said. It lends more support to the FMD’s potential as a short-term periodic, achievable dietary intervention that can help people lessen their disease risk and improve their health without extensive lifestyle changes, he added.

“Although many doctors are already recommending the FMD in the United States and Europe, these findings should encourage many more healthcare professionals to recommend FMD cycles to patients with higher-than-desired levels of disease risk factors as well as to the general population that may be interested in increased function and younger age,” said Dr. Longo.

Fitness Flash: A Surprising Advantage of Exercise 

Fitness Flash

A Surprising Advantage of Exercise 

Looking to improve your fine motor skills? You can benefit from physical exercise both before and after practicing these skills, according to new research from the department of nutrition, exercise, and sports at the University of Copenhagen. This finding also can, among other things, make the way we rehabilitate more effective.

Before a violinist wants to learn a new piece or a surgeon stands at the training table to learn a new surgical technique, they might consider heading out for a bike ride or run. Once they’ve practiced the new skill, there’s good reason to put on their workout attire again. Indeed, being physically active and elevating one’s heart rate has the wonderful side effect of improving our ability to learn by increasing the brain’s ability to remember, stated the researchers. They showed that this effect also applies to the formation of motor memory, enabling us to recall and perform tasks such as riding a bike, driving a car, and lacing up our shoes, almost automatically.

Violinist playing violin

“Our results demonstrate that there is a clear effect across the board. If you exercise before learning a skill, you will improve and remember what you have learned better. The same applies if you exercise after learning,” said Lasse Jespersen, PhD, first author of the study. Specifically, the researchers found around 10% improvement in people’s ability to remember a newly learned motor skill when exercise is included either before or after the new skill. “But our research shows that the greatest effect is achieved if you exercise both before and after,” Dr. Jespersen added.

“This is probably because physical activity increases the brain’s ability to change, which is a prerequisite for remembering,” explained co-author Jesper Lundbye-Jensen, PhD, who heads the department’s movement and neuroscience section. Specific parts of the brain are activated when a person engages in motor practice that requires the acquisition of fine motor skills. If the task is an activity that one knows well, like riding a bicycle, the centers are less active, but that all changes when learning something new. The brain undergoes actual changes, something that is essential for our ability to learn and remember new skills, a phenomenon known as brain plasticity. These changes occur not only while the new skill is acquired through practice but also in the hours after, when the memory is consolidated. This is why it is meaningful to be physically active even after we’ve engaged in something new.

The effect applies to everyone, including children, adolescents, and older adults, and in particular anyone who regularly needs to learn new skills. Moreover, the effects may hold significance for individuals undergoing rehabilitation, aiming to recover mobility and lost motor skills. 

“Typically, rehabilitation is divided between two or three different disciplines. In practice, this may mean that Mr. Smith will have physical training with a physiotherapist on one day, work with an ergonomist the next, and train cognitive abilities with a psychologist on the third. Our research suggests that it could be wise to plan rehabilitation so that these areas are considered together, as doing so could have a synergistic effect,” explained Dr. Lundbye-Jensen. “Coming back often entails hard work, and even slight improvements in efficiency can mean a lot to people in that situation.”

Sixty-seven test subjects were involved in the research project. To ensure comparable data, all subjects were young men between the ages of 18 and 35 who were not physically or mentally impaired in ways that could limit their learning ability and physical performance.

The researchers examined the subjects’ behavior and performance while reviewing one of four possible scenarios. First, the subjects either rested or exercised moderately on a bicycle. After that, they were subjected to a fine motor task in the form of a simple computer game that, with a small device on their fingertips, challenged and practiced their motor dexterity.

Next, they either exercised intensely on a fitness bike or rested. That meant there was one group that rested both before and after, one that trained both times, and two that trained once, either before or after. Their skill level and memory were tested again after seven days to assess whether what they had learned stuck.

As a somewhat unusual criterion, professional musicians and gamers were excluded as possible participants. “People with extensive experience in practicing motor skills typically start at a different level. While the motor task used in the research study was unknown to all, involving experts would have changed the dynamic from the get-go. But that doesn’t mean they wouldn’t benefit from the effects we’ve shown. To the contrary, in a future study, it could be exciting to investigate how exercise affects people with elite-level fine motor skills,” said Dr. Jespersen.

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