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Olive Oil Hunter News #253

Baked Ziti Recipe, Spotlight on Whole Wheat Pasta, Understanding al Dente, How the Nose Fends Off Colds and Fighting Age-Related Muscle Loss

When it comes to comfort food, few dishes can top baked ziti, with its luscious sauce and melted cheeses. And it doesn’t take much effort for all that reward! I’m sharing interesting research that may explain why some people are more prone to colds than others as well as a reminder about maintaining muscle as we age.

Tricolore Soup

  • baked ziti Baked Ziti

    This delectable dish starts with a rich yet quick tomato sauce. You can substitute a 15-ounce can of diced tomatoes with their juice for the fresh tomatoes but add it after the tomato paste. 

    Ingredients

    • 3 tablespoons extra virgin olive oil, plus more for the baking dish and drizzling
    • 2 garlic cloves, chopped
    • 1 pound tomatoes, any type, coarsely chopped
    • One 6-ounce can tomato paste
    • 1 teaspoon sugar
    • 1 teaspoon fine sea salt
    • 1/2 teaspoon crushed red pepper flakes, plus more to taste
    • 1/2 teaspoon freshly ground black pepper
    • 1 pound ziti
    • 16 ounces ricotta cheese
    • 12 ounces mozzarella, thinly sliced
    • 1/3 cup freshly grated Parmigiano-Reggiano cheese

    Directions

    Step 1

    Brush a 13-inch by 9-inch baking dish with olive oil; set aside.

    Step 2

    Heat a medium saucepan over medium heat. When hot, add the 3 tablespoons olive oil and garlic and sauté for 3 minutes, then add the tomatoes. Cook, stirring constantly, until the tomatoes become soft, then push them to the outsides of the pan. Add the tomato paste and cook it until it becomes fragrant and darkens in color, about 5 minutes. Mix the paste with the tomatoes and garlic, then press with a masher to release all of the tomatoes’ juices. Stir in the sugar, salt, and both peppers and continue cooking for 10 minutes.

    Step 3

    Meanwhile, preheat your oven to 350°F. Cook the ziti according to the package directions until al dente, then drain. 

    Step 4

    Off the heat, stir the ricotta into the sauce, then fold in the pasta. Transfer the mixture to the baking dish. Top with overlapping slices of mozzarella, then sprinkle on the grated cheese.

    Step 5

    Bake for 25 minutes, until the cheeses are bubbly. Cool for 10 minutes before serving.

    Yields 8 servings

Healthy Ingredient Spotlight: Whole Wheat Pasta

Healthy Ingredient Spotlight

Whole Wheat Pasta

To add more nutrients and fiber to your ziti, opt for whole wheat pasta. It’s made from the entire wheat kernel—bran, germ, and endosperm—and retains its vitamins and minerals. While it takes a bit longer to cook, follow package directions to be sure it’s al dente.

Quick Kitchen Nugget: Understanding al Dente

Quick Kitchen Nugget

Understanding al Dente

Ziti pasta al dente

Al dente literally means to the tooth—firm when bitten yet not hard or raw tasting. Most Italian cooks boil pasta to this stage regardless of the recipe. Americans tend to like their pasta more tender. But when it will be twice cooked, as with ziti, lasagna, and stuffed shells, it needs to be al dente before it goes into the oven or else it will be too soft.

If your pasta box doesn’t list al dente cooking time, test a piece about 2 minutes sooner than the general directions and see whether it has a bit of bite. If it’s too firm, check it again in a minute. 

For Your Best Health: How the Nose Fends Off Colds

For Your Best Health 

How the Nose Fends Off Colds

When rhinovirus, the most common cause of the common cold, enters the nasal passages, the cells lining the nose immediately begin working together to fight the infection. These cells activate a wide range of antiviral defenses designed to limit the virus and stop it from spreading. In a study published in the journal Cell Press Blue, researchers show that this early response plays a key role in whether a person becomes sick and how severe their symptoms become. The findings suggest that the body’s reaction to rhinovirus often matters more than the virus itself.

“As the number one cause of common colds and a major cause of breathing problems in people with asthma and other chronic lung conditions, rhinoviruses are very important in human health,” said senior author Ellen Foxman, MD, PhD, of the Yale School of Medicine. “This research allowed us to peer into the human nasal lining and see what is happening during rhinovirus infections at both the cellular and molecular levels.”

To closely observe how nasal cells respond to infection, the research team built a lab-grown model of human nasal tissue with multiple cell types found in the human airway, including mucus-producing cells and cells with cilia, the tiny hairlike structures that help move mucus and trapped particles out of the lungs. “This model reflects the responses of the human body much more accurately than the conventional cell lines used for virology research,” Dr. Foxman said.

Using this model, the researchers were able to monitor how thousands of individual cells respond together during infection. They also examined what happened when the cellular sensors responsible for detecting rhinovirus were blocked. These experiments revealed a powerful defense system coordinated by interferons, which are proteins that interfere with viral entry and replication.

When nasal cells detect rhinovirus, they release interferons that activate antiviral defenses not only in infected cells but also in nearby healthy cells. This coordinated response makes it difficult for the virus to reproduce and spread. If interferon activity begins quickly, the infection can be contained early. When the researchers blocked this response, the virus spread rapidly, infecting many more cells and causing significant damage. In some cases, the infected organoids did not survive.

“Our experiments show how critical and effective a rapid interferon response is in controlling rhinovirus infection, even without any cells of the immune system present,” said first author Bao Wang, PhD, of the Yale School of Medicine.

The study also uncovered additional responses that occur when viral replication increases. Under these conditions, rhinovirus can activate a separate sensing system that leads both infected and uninfected cells to produce large amounts of mucus and inflammatory signals. This reaction can contribute to airway inflammation and breathing difficulties in the lungs. According to the researchers, these pathways may offer useful targets for treatments aimed at reducing harmful symptoms while supporting effective antiviral defenses.

“Our study advances the paradigm that the body’s responses to a virus, rather than the properties inherent to the virus itself, are hugely important in determining whether or not a virus will cause illness and how severe the illness will be,” Dr. Foxman said. “Targeting defense mechanisms is an exciting avenue for novel therapeutics.”

Fitness Flash Icon: Fighting Age-Related Muscle Loss 

Fitness Flash

Fighting Age-Related Muscle Loss 

A new study in mice is giving scientists fresh clues about why our muscles lose strength as we get older and why exercise remains one of the most reliable ways to fight it.Researchers at Duke-NUS Medical School found that a gene regulator called DEAF1 seems to push a key muscle-maintenance system into overdrive as we age. When we’re young, the system known as mTORC1 helps build and repair muscle. But later in life, it can get stuck in high gear and begin to damage muscle cells instead.

“The mTORC1 pathway is essential for muscle growth yet becomes chronically overactive in aging—a paradox that has made it challenging to pinpoint what drives this dysregulation,” said the study’s senior author Hong-Wen Tang, PhD, an assistant professor in the Cancer and Stem Cell Program at Duke-NUS and Singapore General Hospital.

Until now, scientists didn’t know what caused this shift. “Identifying DEAF1 fills an important gap in understanding how age-related stress signals become hardwired into a persistent anabolic state that ultimately harms muscle cells,” Dr. Tang said.

The study suggests DEAF1 essentially hits the gas on a system already running too fast. By pushing mTORC1 into overdrive, DEAF1 causes muscles to make too many proteins, fail to clear damaged ones, and gradually weaken.

Seniors weight-lifting outdoors

One of the most surprising findings: Exercise reverses this process by lowering DEAF1 levels. That means in addition to building muscle, physical activity helps reset the core cellular pathways that keep muscles healthy. “It was a striking discovery,” said Dr. Tang. “It shows that exercise doesn’t just fix damage; it targets the switch that causes muscle aging in the first place.”

Scientists didn’t just look at whether exercise keeps muscles strong—they wanted to know how it does it. They put aging mice through endurance workouts, including an exhausting treadmill run. For comparison, another group of older mice stayed sedentary. After the workouts, the exercising mice showed big drops in mTORC1, the overactive pathway linked to muscle loss and function known as sarcopenia.

Researchers found that exercise lowers DEAF1 through a well-known set of longevity genes called FOXO. When activated during exercise, FOXO suppresses DEAF1—lifting the foot off the gas pedal—and helps mTORC1 return to normal. Their work highlights a new biological pathway—the FOXO-DEAF1-mTORC1 axis—that helps explain why muscles weaken with age and why exercise remains such a powerful antidote to age-related decline. 

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Baked Ziti

This delectable dish starts with a rich yet quick tomato sauce. You can substitute a 15-ounce can of diced tomatoes with their juice for the fresh tomatoes but add it after the tomato paste. 

Ingredients

  • 3 tablespoons extra virgin olive oil, plus more for the baking dish and drizzling
  • 2 garlic cloves, chopped
  • 1 pound tomatoes, any type, coarsely chopped
  • One 6-ounce can tomato paste
  • 1 teaspoon sugar
  • 1 teaspoon fine sea salt
  • 1/2 teaspoon crushed red pepper flakes, plus more to taste
  • 1/2 teaspoon freshly ground black pepper
  • 1 pound ziti
  • 16 ounces ricotta cheese
  • 12 ounces mozzarella, thinly sliced
  • 1/3 cup freshly grated Parmigiano-Reggiano cheese

Directions

Step 1

Brush a 13-inch by 9-inch baking dish with olive oil; set aside.

Step 2

Heat a medium saucepan over medium heat. When hot, add the 3 tablespoons olive oil and garlic and sauté for 3 minutes, then add the tomatoes. Cook, stirring constantly, until the tomatoes become soft, then push them to the outsides of the pan. Add the tomato paste and cook it until it becomes fragrant and darkens in color, about 5 minutes. Mix the paste with the tomatoes and garlic, then press with a masher to release all of the tomatoes’ juices. Stir in the sugar, salt, and both peppers and continue cooking for 10 minutes.

Step 3

Meanwhile, preheat your oven to 350°F. Cook the ziti according to the package directions until al dente, then drain. 

Step 4

Off the heat, stir the ricotta into the sauce, then fold in the pasta. Transfer the mixture to the baking dish. Top with overlapping slices of mozzarella, then sprinkle on the grated cheese.

Step 5

Bake for 25 minutes, until the cheeses are bubbly. Cool for 10 minutes before serving.

Yields 8 servings

Olive Oil Hunter News #252

Tricolore Soup Recipe, Spotlight on Kidney Beans, Colanders and Strainers, Benefits of Monk Fruit, and Workouts Burn More Calories than Previously Thought

I love a hearty soup that delivers nourishing warmth with great taste. My combination of beans, barley, and broccoli is a flavorful hit! If you’re a fan of monk fruit as a sweetener, you’ll be wowed by the nutritional bounty of this gourd. I’m also sharing the latest research on calories burned during exercise—motivation to get moving.

Tricolore Soup

  • tricolore soup Tricolore Soup

    “Tricolore” refers to the three colors of the Italian flag, but this recipe has surprising choices for the red, white, and green—kidney beans, barley, and broccoli! Notes: Choose hull-less rather than pearl barley for better taste and more fiber. Always save and freeze Parmigiano-Reggiano rinds as they add great flavor to soups and stews.

    Ingredients

    • 1 cup hull-less barley, uncooked
    • 3 tablespoons extra virgin olive oil, plus more for drizzling
    • 2 garlic cloves, minced
    • 1 pound broccoli florets, coarsely chopped
    • 6 cups homemade or store-bought low-sodium chicken or vegetable broth
    • Optional: rind from a block of Parmigiano-Reggiano cheese
    • One 15.5-ounce can red kidney beans, rinsed and drained
    • Fine sea salt to taste
    • Freshly ground black pepper to taste
    • Shavings of Parmigiano-Reggiano cheese

    Directions

    Step 1

    In a medium saucepan, bring the barley and 4 cups of water to a boil. Lower the heat to a simmer and cook until tender, an hour or more. When the barley is done, all the water should have evaporated. Check it regularly in case the water evaporates before the barley is cooked through.

    Step 2

    Heat a stockpot over medium-high heat. When hot, add the 3 tablespoons olive oil and the garlic. Sauté until the garlic softens. Add the broccoli, broth, and, if using, the cheese rind. Bring to a simmer and cook until the broccoli is tender, about 12 minutes. Add in the cooked barley and beans and heat through. Season to taste with salt and pepper.

    Step 3

    Serve with large shavings of cheese and a drizzle of olive oil. 

    Yields 6 servings

Healthy Ingredient Spotlight: Red Kidney Beans

Healthy Ingredient Spotlight

Red Kidney Beans

Named for their red color and their shape, kidney beans are a type of legume that come in light- and dark-red shades. Because they’re very firm, they retain their texture well in recipes. Kidney beans are a great source of fiber and protein, delivering 7 grams of each in a half-cup. You’ll also get folate and vitamin B1 along with minerals including iron, manganese, and phosphorus. What’s more, eating beans helps control cholesterol and blood sugar and may boost heart and colon health.

red kidney beans in colander
Quick Kitchen Nugget: Colanders and Strainers

Quick Kitchen Nugget

Colanders and Strainers

Though many recipes call for straining or draining foods, they rarely specify what tool to use. Depending on the specific task at hand, you’ll need either a colander or a strainer. What’s the difference? The overall size and the size of the openings. Simply put, a colander is a footed bowl with two handles and large holes for draining foods like just-boiled potatoes and pasta and rinsing raw fruits, vegetables, and even canned beans. A strainer is a handheld gadget with a scoop-like surface made of mesh for jobs like straining cocoa to remove lumps or sifting confectioners’ sugar over baked goods. It’s also handy when you want to strain out very small ingredients, like seeds. Some strainers have a finer mesh than others. In general, it’s very helpful to have at least two sizes of each tool, typically made from stainless steel for durability.

For Your Best Health: Benefits of Monk Fruit

For Your Best Health 

Benefits of Monk Fruit

Scientists are taking a closer look at monk fruit and discovering it’s more than just a zero-calorie natural sweetener. Luo han guo (Siraitia grosvenorii), more commonly known as monk fruit, is a long-living vine that belongs to the gourd family, the same plant group as cucumbers and squash. It’s native to southern China, where it has been used for centuries in traditional foods and remedies. In recent years, monk fruit has drawn scientific attention because it contains high levels of antioxidants, which help protect cells from damage caused by unstable molecules—free radicals which have been linked to aging and many chronic diseases. New findings published in the Journal of the Science of Food and Agriculture looked at the specific chemical compounds of monk fruit and how they may support health.

One of the most important features of monk fruit is its abundance of what’s called secondary metabolites. These are natural plant chemicals that are not required for basic human growth but often play a role in health. In this case, researchers concentrated on three major groups: terpenoids, flavonoids, and amino acids. They examined both the peel and the pulp of four different monk fruit varieties and were able to identify where these compounds are concentrated and how they behave biologically. The study further explored how they interact with antioxidant receptors and other biological targets. (Receptors are structures in cells that receive chemical signals and trigger responses in the body.) These interactions influence various biological pathways, which are step-by-step processes that help regulate functions such as inflammation, metabolism, and cellular protection. Understanding these pathways helps explain why monk fruit may have health promoting properties beyond its use as a natural sweetener.

The researchers emphasized that not all monk fruit is chemically identical. Different varieties can contain different levels and combinations of active compounds. As the authors explained, “[I]t is crucial to conduct an in-depth investigation on the high-resolution metabolic profiles of different luo han guo varieties, providing valuable insights into the nutritional and health characteristics as well as the manufacturing suitability of the various resources available from this plant.” This type of detailed chemical mapping helps scientists determine which varieties may be best suited for food products, supplements, or other uses. 

Fitness Flash Icon: Workouts Burn More Calories than Previously Thought

Fitness Flash

Workouts Burn More Calories than Previously Thought

For years, researchers have debated whether the body treats energy like a fixed paycheck or a flexible bonus system. One idea suggests that when people move more, the body shifts energy away from other tasks to pay for that activity. The other model proposes that energy use can expand, allowing total daily expenditure to rise as activity increases. Researchers, led by scientists at Virginia Tech working with colleagues from the University of Aberdeen and Shenzhen University, set out to learn which of these ideas best reflect what actually happens across different activity levels.

To do so, the team measured total energy expenditure, meaning the total number of calories burned in a day, among 75 participants between the ages of 19 and 63, with widely varying activity levels that ranged from largely inactive to ultra-endurance running. “Our study found that more physical activity is associated with higher calorie burn, regardless of body composition, and that this increase is not balanced out by the body reducing energy spent elsewhere,” said Kevin Davy, PhD, a professor in the Department of Human Nutrition, Foods, and Exercise at Virginia Tech and the principal investigator of the study. Physical activity continues to affect the body even after the movement itself has ended. More movement leads to more calories burned. 

Resistance training to burn calories

To measure calories burned, the researchers had the participants drink special forms of oxygen and hydrogen and provide urine samples over a two-week period. Oxygen leaves the body as both water and carbon dioxide, while hydrogen exits only as water. By comparing how much of each isotope was lost, researchers could estimate how much carbon dioxide participants produced and, in turn, how much energy they used. Physical activity was tracked using a small waist-worn sensor that recorded movement in multiple directions.

The results showed that as people moved more, their total energy use increased accordingly. The body did not appear to compensate by dialing down energy use elsewhere. Essential functions such as breathing, blood circulation, and temperature regulation continued to require the same amount of energy, even as physical activity rose. This means the body does not clearly offset or cancel out the extra calories burned through movement.

The researchers also observed a strong connection between higher activity levels and reduced time spent sitting. Simply put, people who move more tend to spend less time being inactive overall. 

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Tricolore Soup

“Tricolore” refers to the three colors of the Italian flag, but this recipe has surprising choices for the red, white, and green—kidney beans, barley, and broccoli! Notes: Choose hull-less rather than pearl barley for better taste and more fiber. Always save and freeze Parmigiano-Reggiano rinds as they add great flavor to soups and stews.

Ingredients

  • 1 cup hull-less barley, uncooked
  • 3 tablespoons extra virgin olive oil, plus more for drizzling
  • 2 garlic cloves, minced
  • 1 pound broccoli florets, coarsely chopped
  • 6 cups homemade or store-bought low-sodium chicken or vegetable broth
  • Optional: rind from a block of Parmigiano-Reggiano cheese
  • One 15.5-ounce can red kidney beans, rinsed and drained
  • Fine sea salt to taste
  • Freshly ground black pepper to taste
  • Shavings of Parmigiano-Reggiano cheese

Directions

Step 1

In a medium saucepan, bring the barley and 4 cups of water to a boil. Lower the heat to a simmer and cook until tender, an hour or more. When the barley is done, all the water should have evaporated. Check it regularly in case the water evaporates before the barley is cooked through.

Step 2

Heat a stockpot over medium-high heat. When hot, add the 3 tablespoons olive oil and the garlic. Sauté until the garlic softens. Add the broccoli, broth, and, if using, the cheese rind. Bring to a simmer and cook until the broccoli is tender, about 12 minutes. Add in the cooked barley and beans and heat through. Season to taste with salt and pepper.

Step 3

Serve with large shavings of cheese and a drizzle of olive oil. 

Yields 6 servings