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Why Olive Oil Is So Good for the Heart

Posted on by The Olive Oil Hunter

The following article by Alice. G Walton is reprinted from Forbes, May 20, 2014.

New research in Proceedings of the National Academy of Sciences looks at the effect of the Mediterranean diet on heart health—and the verdict is favorable. But even more than that, the study lays out exactly why olive oil and greens are together so beneficial for the heart.

Until now, researchers hadn’t quite been able to explain why a diet as high in fat as the Mediterranean diet is linked to cardiovascular health. Researchers have wondered what exactly it is about the fats that helps the heart, and now they’ve arrived a pretty convincing mechanism to explain it.

The trick is to create a “fusion” of the healthy fats in, say, olive oil and the nitrites and nitrates in greens like spinach, celery, and carrots, which make up a large part of the Mediterranean diet. This fats–greens pairing, according to the researchers, creates a compound—nitro fatty acid—that has the effect of relaxing blood vessels and bringing down blood pressure, which are key components of heart health.

To test the theory, the team fed mice—with high blood pressure—the omega-6 fatty acids found in olive oil. They also added to their diets sodium nitrite, in order to mimic the pairing of olive oil and veggies. Indeed, not only was the level of nitro fatty acids higher in these mice, but their blood pressure was lower at the end of the 5-day intervention. And when the researchers used a strain of mice that were resistant to the effects of the nitro fatty acids, their blood pressure did not change.

Though the research was done in mice, the mechanism likely applies to people, too. Earlier research has pointed to the benefits of olive oil and nuts on cardiovascular health in humans.

“The findings of our study,” said study author Philip Eaton, “help to explain why previous research has shown that a Mediterranean diet supplemented with extra-virgin olive oil or nuts can reduce the incidence of cardiovascular problems like stroke, heart failure and heart attacks.” Avocados may work too, the team told the BBC, since they also contain healthy unsaturated fats.

Mediterranean diet may help stop breast cancer coming back, study says

Posted on by The Olive Oil Hunter

The following is excerpted from an article by Sarah Bosley that appeared in the Guardian on June 5, 2016.

Eating a Mediterranean diet, rich in fruit, vegetables, fish and olive oil, may help prevent breast cancer returning, according to a study presented at a major international cancer conference.

Lifestyle—whether people are physically active or not—and being overweight are known risk factors for breast cancer, but there is increasing interest in whether particular eating habits play a part in its occurrence and recurrence.

The study presented at the American Society of Clinical Oncology (ASCO) meeting in Chicago is a trial in Italy that compared the outcomes for 307 women who had been treated for early breast cancer. One group of 199 women were asked to eat a Mediterranean diet, involving four portions of vegetables, three pieces of fruit and one serving of grains a day, together with four or more servings of fi sh each week, some red and processed meat and plenty of olive oil. They were allowed up to one alcoholic drink a day.

The other group of 108 women were asked to eat their normal diet, but given advice on healthy food by a dietician.

The cancer researchers at Piacenza hospital, Italy, found that after three years, 11 women from the group eating a normal diet suffered a return of their breast cancer, while none of those eating a Mediterranean diet did.

Experts say the study is small and has limitations, but raises issues of great interest. “The whole topic of lifestyle interventions for breast cancer survivors is a very important one. There is substantial research going on into what we should be recommending,” said Dr. Erica Mayer, an ASCO expert in breast cancer, assistant professor at Harvard Medical School and director of clinical research at the Dana-Farber Cancer Institute in the US.

But the results of studies to date have been conflicting. “It is not clear whether there is a specific diet or foods to eat or not to eat to prevent recurrence,” she said. Physical activity, on the other hand, is very beneficial, helping to prevent cancer both occurring and recurring.

The signals so far from research into women’s eating habits and breast cancer “probably reflect weight loss rather than diet,” she said. On this particular study there were issues with the methodology. “They don’t say if this is randomized. People were asked to participate in one diet or the other. There is no information about the activity level or change in weight, which for most of the lifestyle research one needs to be aware of,” she said.

Lady Delyth Morgan, the chief executive of Breast Cancer Now, said: “This study adds to increasingly interesting discussions about how lifestyle factors might influence breast cancer recurrence.

“We need to see results from longer-term studies before we can give specific diet advice to breast cancer patients. In the meantime we do know that a varied, balanced diet for general health and well-being, as well as being physically active, can be beneficial to breast cancer patients.”

Reference: Biasini C, Di Nunzio C, Cordani MR, et al. Effect of Mediterranean diet on the prevalence of breast cancer relapse: preliminary results of the “SETA PROJECT.” Ann Oncol. 2015;26(suppl 6):vi4; doi: 10.1093/annonc/mdv336.05. Presented at 17th National Congress of Medical Oncology, October 23–25, 2015, Rome, Italy. http://annonc.oxfordjournals.org/content/26/suppl_6/vi4.2

Extra virgin olive oil may reduce Alzheimer’s risk, study reports

Posted on by The Olive Oil Hunter

Reprinted from an article by Joseph Scalise in Science Recorder, June 22, 2017

Researchers from Temple University have found that extra virgin olive oil may help protect against memory loss and reduce many of the conditions associated with Alzheimer’s disease, a new study published in the journal Annals of Clinical and Translational Neurology reports.

The team made this discovery by looking at how olive oil–enriched diets affected the memory and learning abilities of mice. To do this, they split the rodents into two groups: one that ate olive oil and one that did not. While all of the mice looked the same after months on their respective diets, the rodents on the olive oil diet had better working and spatial memory than those that ate normal food.

Olive oil is the cornerstone of the Mediterranean diet and has been linked to numerous health benefits. This study builds on previous research by showing more of its advantages. Not only did the oil reduce brain inflammation, it also activated the autophagy process, which removes debris and toxins—including ones associated with Alzheimer’s—from the brain.

“The thinking is that extra-virgin olive oil is better than fruits and vegetables alone, and, as a monounsaturated vegetable fat, it is healthier than saturated animal fats,” said study co-author Domenico Praticò, a researcher at Temple University, in a statement.

Alzheimer’s disease is the most common form of dementia in the United States. There is currently no cure. Estimates from the US Centers for Disease Control and Prevention state that 5 million Americans contracted the illness in 2013, and that number is expected to rise to 14 million by 2050.

Researchers hope findings such as this can spur new studies and lead to a better understanding of how diet affects neurological disorders. They plan to follow up on their study by introducing extra virgin olive oil later on in the aging process to see what other benefits it might have.

“Thanks to the autophagy activation, memory, and synaptic integrity were preserved, and the pathological effects in animals otherwise destined to develop Alzheimer’s disease were significantly reduced,” Praticò said, according to USA Today. “We want to know whether olive oil added at a later time point in the diet can stop or reverse the disease.”

Preventive Medicine: Secrets of Olive Oil Explained

Posted on by The Olive Oil Hunter

Adapted from an article in the New Haven Register by Dr. David Katz, July 1, 2018

In late June 2018, Yale University hosted the Mediterranean Diet Roundtable conference. Among the presentations were two by world-leading experts in the bioactive components of olive oil, Eleni Melliou, PhD, and Prokopios Magiatis, PhD, both from the University of Athens.

Among those many compounds is oleocanthal, a polyphenol and potent antioxidant found in olives. It is established to inhibit COX1 and COX2 enzymes. What does that mean? The first, inhibition of COX1, is what ibuprofen does. The second, inhibition of COX2, is what Celebrex does. So, oleocanthal-rich olive oil (let’s call this “OROO”) has potent anti-inflammatory, and potentially analgesic (pain reducing) properties. What does the research show?

As presented by my colleagues from Athens, a study of OROO in 200 men in Spain showed a linear increase in protective HDL cholesterol, and a decline in LDL cholesterol. In a study of 24 women with hypertension, OROO was found to lower blood pressure, improve endothelial function and lower CRP, an important inflammatory marker. Multiple other studies cited by my Greek colleagues replicated these effects.

OROO has been shown to inhibit platelet aggregation as well, the mechanism responsible for acute myocardial infarction. Like ibuprofen, aspirin inhibits COX1, so there is a clear case for the actions of compounds in olive oil to resemble effects seen with these drugs.

Aspirin is used routinely as a cardioprotective agent because it inhibits platelet aggregation.

Oleocanthal derived from olive oil has been shown to induce the clearance of the plaques associated with Alzheimer’s disease from the brains of experimental animals. Results of a human trial, announced just last month, showed an improvement in Alzheimer’s symptoms, and delayed progression of the disease, with OROO.

Oleocanthal has also been shown to induce cancer cell death. In an ongoing study of patients with chronic lymphocytic leukemia, OROO daily for three months significantly reduced the numbers of cancerous white blood cells relative to placebo.

Now, let’s put it all in context.

The active compounds in olive oil, like oleocanthal, are highly concentrated in the unripe olives used to make cold-pressed, extra virgin olive oil. They are almost completely absent from the ripe olives used to make the lesser varieties of olive oil that often populate the shelves of American supermarkets. Details matter.

The above does not make the case that olive oil, or a Mediterranean diet, is required for good health. But the above certainly does make the case that genuinely good olive oil has genuinely good health effects. No surprise, then, that of the world’s five Blue Zone populations, two have OROO-rich, Mediterranean diets. That, too, is evidence that matters.

I find the weight of evidence regarding extra virgin olive oil, OROO, and oleocanthal extremely compelling. I am fully persuaded that “good” olive oil is a signature contributor to the many benefits of one of the world’s truly great diets.

I am also persuaded, however, again based on the full weight of relevant evidence, that no one food or nutrient accounts for the net effects of the overall diet. The one true toxin I see all too often in the mix—corrosive to consensus, understanding, common ground, and common cause—is cherry-picked science to make the case for any given diet. The pits are concentrated there, so be careful not to swallow that!